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- What is fenoprofen, and how does it work (mechanism of action)?
- What brand names are available for fenoprofen?
- Is fenoprofen available as a generic drug?
- Do I need a prescription for fenoprofen?
- What are the side effects of fenoprofen?
- What is the dosage for fenoprofen?
- Which drugs or supplements interact with fenoprofen?
- Is fenoprofen safe to take if I'm pregnant or breastfeeding?
- What else should I know about fenoprofen?
What is fenoprofen, and how does it work (mechanism of action)?
Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is effective for treating the fever, pain, and swelling caused by inflammation. Fenoprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of the NSAID class of drugs include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for the pain, fever, and swelling of inflammation. Fenoprofen blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, swelling, pain and fever are reduced. Fenoprofen was approved by the FDA in March 1976.
What are the side effects of fenoprofen?
Common side effects include:
- ringing in the ears,
- abdominal pain,
- fluid retention, and
- dry mouth.
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Fenoprofen also may cause stomach and intestinal bleeding and ulcers. Sometimes, stomach ulceration and intestinal bleeding may occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of the bleeding.
People who are allergic to other NSAIDs should not use fenoprofen. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to fenoprofen and other NSAIDs. Fluid retention, blood clots, heart attacks, high blood pressure (hypertension), and heart failure also have been associated with the use of NSAIDs.
Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment
What is the dosage for fenoprofen?
The recommended adult dose for mild to moderate pain is 200 mg every 4-6 hours.
Fenoprofen should be administered with meals in order to avoid stomach upset.
The safety and effectiveness of this drug in patients under age 18 has not been examined.
Which drugs or supplements interact with fenoprofen?
Fenoprofen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most commonly suspected interactions.
- Fenoprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Fenoprofen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When NSAIDs are used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid fenoprofen because fenoprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking fenoprofen or other NSAIDs.
Is fenoprofen safe to take if I'm pregnant or breastfeeding?
It is not known if fenoprofen is excreted in breast milk.
What else should I know about fenoprofen?
What preparations of fenoprofen are available?
Capsule: 200, 400 mg; Tablet: 600 mg
How should I keep fenoprofen stored?
Fenoprofen should be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a sealed container to avoid moisture.
Medically reviewed by John P. Cunha, DO, FACOEP
FDA Prescribing Information
Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment
Fenoprofen (Nalfon) is a nonsteroidal antiinflammatory drug (NSAID) used for the treatment of pain and inflammation due to osteoarthritis and rheumatoid arthritis. Fenoprofen (Nalfon) is also used for the treatment of mild to moderate pain for conditions such as menstrual cramps, tendinitis, and bursitis. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
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Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Tramadol: for Pain (Ultram, Ultram ER, Conzip)
- meloxicam (Mobic) Side Effects
- ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, and others)
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- Drugs: What You Should Know About Your Drugs
- celecoxib, Celebrex
- Drug Interactions
- nabumetone, Relafen (Discontinued)
- etodolac, Lodine (Discontinued)
- flurbiprofen (Ansaid is a discontinued brand)
- oxaprozin, Daypro
- diflunisal, Dolobid
- ketoprofen (Discontinued brands: Nexcede, Orudis, Oruvail, Actron)
- valdecoxib, Bextra
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FDA Prescribing Information
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Ankylosing SpondylitisWhat is ankylosing spondylitis? Take this quiz to learn the causes, symptoms, and treatments for this painful disorder.
ArthritisArthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Foot PainFoot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Hip BursitisBursitis of the hip results when the fluid-filled sac (bursa) near the hip becomes inflamed due to localized soft tissue trauma or strain. Symptoms include stiffness and pain around the hip joint. If the hip bursa is not infected, hip bursitis can be treated with ice compresses, rest, and anti-inflammatory and pain medications.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Low Back PainThere are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
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Neck PainNeck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
OsteoarthritisOsteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Osteoarthritis PictureOsteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints. See a picture of Osteoarthritis and learn more about the health topic.
Take the Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
Rheumatoid ArthritisRheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.
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Shoulder BursitisShoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition. Symptoms include pain, swelling, tenderness, and pain with movement of the shoulder joint. Treatment may involve ice compresses, rest, and anti-inflammatory medications and depends on whether there is an infection.