Medically Reviewed on 3/30/2022

Generic Name: fenofibrate

Brand Names: Tricor, Lofibra tablets (discontinued), Fenoglide, Lipofen, Triglide, Antara

Drug Class: Fibric Acid Agents

What is fenofibrate, and what is it used for?

Fenofibrate is a medication used to modulate the levels of fatty substances (lipids) in the blood. Fenofibrate, used in addition to a low-fat diet, reduces blood levels of triglycerides and the types of cholesterol that increase the risk for plaque buildup in arteries (atherosclerosis), and increases the type of cholesterol that is beneficial to health. 

  • Triglycerides and cholesterol are synthesized in the liver and also absorbed from our dietary intake. While lipids are essential for many functions in the body, excess levels can clog up blood vessels and increase the risk for heart disease, stroke and other diseases. Following are the main types of lipids in the body:
  • Triglycerides: The most common form of fat that the body uses as fuel for energy and to store extra energy.
  • Cholesterol: A waxy combination of lipid and protein (lipoprotein) that the body uses to build cell membranes, produce hormones, bile acids and vitamin D.
  • LDL cholesterol: Low density lipoprotein (LDL) carries cholesterol to cells all over the body.
  • VLDL cholesterol: Very low density lipoprotein (LDL) is made by the liver to transport triglycerides to the cells; VLDL turns into LDL after delivering triglycerides to the cells.
  • HDL cholesterol: High density lipoprotein (HDL) absorbs cholesterol from the cells and transports it back to the liver to be converted into bile acids which aid digestion of dietary fat and get excreted.

Fenofibrate reduces the levels of triglycerides, total cholesterol, LDL and VLDL cholesterol, and increases HDL cholesterol levels. Fenofibrate works by activating peroxisome proliferator activated receptor-alpha (PPAR-A), a nuclear receptor protein in the liver. This results in:

  • Activation of lipoprotein lipase, the enzyme that breaks down triglyceride-rich lipoproteins, leading to lower levels of triglycerides and apolipoprotein B, the protein component of LDL and VLDL cholesterol.
  • Increase in the synthesis of HDL cholesterol and its major protein components apolipoproteins A-I and A-II.

Fenofibrate also reduces uric acid levels by increasing the excretion of uric acid in the urine. Fenofibrate is used to treat:


  • Do not administer fenofibrate to patients with hypersensitivity to fenofibrate or any of its components
  • Do not administer fenofibrate to patients with:
  • Fenofibrate at a dose equivalent to 145 mg of Tricor was not seen to reduce coronary heart disease morbidity and mortality in a large, randomized controlled trial of patients with type 2 diabetes mellitus
  • Fenofibrate increases risk for muscle disease and muscle breakdown (rhabdomyolysis); monitor creatine phosphokinase levels
  • Discontinue if liver enzymes persist at 3 times above the upper normal limit
  • Discontinue use if symptoms of gallstones develop
  • Increases serum creatinine levels; monitor kidney function in patients at risk for kidney damage
  • Decrease in platelets and immune cells (granulocytes) may occur; monitor blood count periodically in the first year of therapy
  • Use with caution in patients on oral anticoagulants and adjust doses appropriately
  • May increase the risk for pulmonary embolism and deep vein thrombosis (DVT); use with caution in patients with risk factors for venous thromboembolism
  • May cause paradoxical drop in HDL cholesterol levels

What are the side effects of fenofibrate?

Common side effects of fenofibrate include:

Less common side effects of fenofibrate include:

This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.

Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.


What is cholesterol? See Answer

What are the dosages of fenofibrate?

TriCor tablet

  • 48mg
  • 145mg

Lofibra tablet

  • 54mg
  • 160mg

Fenoglide tablet

  • 40mg
  • 120mg

Triglide tablet

  • 160mg

Lipofen capsule

  • 50mg
  • 150mg



  • Hypercholesterolemia, mixed dyslipidemia: Initially, 145 mg orally once a day
  • Hypertriglyceridemia: Initially, 48-145 mg orally once a day
  • Titrate q4-8 week up to no more than 145 mg orally once a day


  • Hypercholesterolemia, Mixed Dyslipidemia: initial 160 mg orally once a day
  • Hypertriglyceridemia: 50-160 mg orally once a day initially


  • Hypercholesterolemia, Mixed Dyslipidemia: initial 150 mg orally once a day
  • Hypertriglyceridemia: initial 50-150 mg orally once a day

Lofibra tablets

  • Hypercholesterolemia, Mixed Dyslipidemia: 160 mg orally once a day
  • Hypertriglyceridemia: 54-160 mg orally once a day


  • Hypercholesterolemia, Mixed Dyslipidemia: 120 mg orally once a day
  • Hypertriglyceridemia: 40-120 mg orally once a day

Dosing Modifications

Renal impairment

  • TriCor (CrCl <50 mL/min): 48 mg/day initially; evaluate before increase dose
  • Triglide: Initial, 50 mg/day
  • Lipofen: Initial, no more than 50 mg/day
  • Lofibra tablets: Initial, 54 mg/day
  • Fenoglide: Initial, 40 mg/day

Dosing Considerations

  • Rule out secondary causes of hyperlipidemia before initiating therapy
  • Withdraw therapy if no adequate response seen after 2-3 months
  • Use with caution in the elderly; dose adjustments may be necessary


  • TriCor, Triglide, and Lofibra tablets can be taken without regard to meals
  • Lipofen: Take with meals



  • Hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia
  • Initial: 48 mg/day; evaluate before increase dose


  • Hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia
  • Initial: 50 mg/day


  • Hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia
  • Initial: No more than 50 mg/day

Lofibra tablets

  • Hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia
  • Initial: 54 mg/day


  • Hypercholesterolemia, mixed dyslipidemia, hypertriglyceridemia
  • Initial: 40 mg/day


  • Safety and efficacy not established


  • Symptoms of fenofibrate overdose include gastrointestinal distress.
  • There is no specific treatment for overdose, treatment is supportive and symptomatic.
  • If indicated, unabsorbed drugs may be removed from the stomach by induced vomiting or gastric lavage.

What drugs interact with fenofibrate?

Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.

The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.

It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.

Pregnancy and breastfeeding

  • There is insufficient data on fenofibrate use in pregnancy to determine risk of miscarriage, maternal risks or fetal harm; use only if potential benefit justifies potential risk to fetus.
  • There is no information on the presence of fenofibrate in human milk, and its effects on the breastfed infant or on milk production. Fenofibrate is present in milk of rats, and likely to be present in human milk. Breastfeeding women should avoid use because of the potential for serious adverse reactions in breastfed infants, such as disruption of infant lipid metabolism.

What else should I know about fenofibrate?

For fenofibrate therapy to be effective in maintaining optimal lipid levels, it is also important to:


Fenofibrate is a medication used to reduce blood levels of triglycerides and the types of cholesterol that increase the risk for plaque buildup in arteries (atherosclerosis). Common side effects of fenofibrate include abnormal liver function tests, increase in liver enzymes ALT and AST, increase in creatine phosphokinase (CPK), respiratory disorder, abdominal pain, headache, back pain, nausea, constipation, and nasal inflammation (rhinitis). Do not take fenofibrate if you are breastfeeding. Consult your doctor if pregnant.

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Medically Reviewed on 3/30/2022