What is the difference between Femara and Clomid?
- Femara (letrozole) and Clomid (clomiphene) are fertility medications used for stimulating ovulation.
- Femara is an anti-estrogen drug typically used for treating postmenopausal women with breast cancer.
- Side effects of Femara and Clomid that are similar include nausea, vomiting, headache, and muscle aches or pains.
- Side effects of Femara that are different from Clomid include fatigue, diarrhea, constipation, chest pain, increased cholesterol levels, and decreased bone mineral density (which increases the risk of osteoporosis and bone fractures).
- Side effects of Clomid that are different from Femara include ovarian enlargement, flushing (warmth, redness, or tingly feeling), stomach discomfort, breast discomfort, blurred vision, abnormal heart beats, acne, allergic reactions, and uterine bleeding.
What are Femara and Clomid?
- Femara (letrozole) is an oral, anti-estrogen drug that is used for treating postmenopausal women with breast cancer. The growth of some breast cancers in postmenopausal women is promoted by estrogens that circulate in the blood, and the adrenal glands are the main source of these circulating estrogens. Femara inhibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone.
- Clomid (clomiphene) is an oral medication used for stimulating ovulation. Clomid is prescribed to stimulate ovulation in women with ovulatory dysfunction who are not pregnant, do not have abnormal bleeding or ovarian cysts, and have normal liver function. It binds to estrogen receptors in the hypothalamus, pituitary gland, ovary, endometrium, vagina, and cervix. It causes production of hormones (gonadotropins) by the pituitary, which stimulates ovulation.
What are the side effects of Femara and Clomid?
Femara side effects
The most common side effects with letrozole are:
- nausea,
- vomiting,
- fatigue,
- headache,
- muscle aches,
- diarrhea,
- constipation, and
- chest pain.
Cholesterol levels may increase during letrozole therapy. Cholesterol levels should be monitored and some patients may require treatment for high cholesterol levels. Letrozole decreases bone mineral density, increasing the risk of osteoporosis and fractures.
Clomid side effects
The most common side effects of clomiphene are:
- ovarian enlargement,
- flushing,
- stomach discomfort,
- breast discomfort,
- blurred vision,
- nausea, and
- vomiting.
Other important side effects include
- abnormal heart beats,
- acne,
- allergic reactions,
- headaches,
- uterine bleeding,
- back pain, and
- muscle pain.
What is the dosage of Femara vs. Clomid?
Femara dosage
- The recommended dose is 2.5 mg once daily with or without food. Patients with severe liver impairment should receive 2.5 mg every other day.
Clomid dosage
- The recommended dose is 50 to 100 mg orally for 5 days. The initial dose is 50 mg which may be increased to 100 mg if there is no response. Dosage may be repeated as early as 30 days after the previous treatment.
What drugs interact with Femara and Clomid?
Femara drug interactions
- Tamoxifen reduces blood levels of letrozole when both drugs are administered together.
- However, in clinical studies the benefit of letrozole was not reduced when administered immediately after tamoxifen. Letrozole is an anti-estrogen drug. Therefore, estrogen containing products counteract the effect of letrozole.
Clomid drug interactions
- No drug interactions are listed in the prescribing information.

SLIDESHOW
Stages of Pregnancy: Week by Week See SlideshowAre Femara and Clomid safe to take while pregnant or breastfeeding?
Femara
- Letrozole damages the fetus. It should not be taken by pregnant women. It is not known if letrozole is secreted into breast milk.
Clomid
- Clomiphene should not be taken by pregnant women since it does not offer any benefit to pregnant women.
- It is not known whether clomiphene is excreted into breast milk. It may reduce lactation in some women.
Summary
Femara (letrozole) and Clomid (clomiphene) are fertility medications used for stimulating ovulation. Femara is an anti-estrogen drug typically used for treating postmenopausal women with breast cancer. Side effects of Femara and Clomid that are similar include nausea, vomiting, headache, and muscle aches or pains.
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Treatment & Diagnosis
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- Breast Cancer: Clinical Trials - Today's Cutting Edge
- Breast Cancer FAQs
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- Ovulation Calculator
- Stress and Aggressive Breast Cancer: Cause or Effect?
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- Angelina Jolie's Mastectomy
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- Can Ovarinan Cysts Cause Infertility?
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- Does Positive Additude Affect Breast Cancer?
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- How Common and Dangerous Is Male Breast Cancer?
- How Many Breast Cancer Deaths Are there Each Year?
- Where Can Breast Cancer Spread To?
- Why Is Breast Cancer More Common in Females than Males?
- How Much Breast Cancer is Genetic?
- How Long Can Breast Cancer Patients Live?
- Who Does Breast Cancer Affect?
- How Does Breast Cancer Form?
- Can Stress Reduce Fertility?
- How Many Breast Cancer Stages Are There?
- Does Stress Affect Male Fertility?
- Does Endometriosis Cause Infertility?
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- Facts on Breast Cancer Causes, Risk Factors, and Types
- Breast Cancer Symptoms and Signs
- Breast Cancer Detection
- Acupuncture for Infertility
- Breast Cancer Treatment
- Trying to Conceive: Clomid Questions
- Infertility: Ten Questions to Ask Your Doctor About Infertility
Medications & Supplements
Prevention & Wellness

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top Femara letrozole vs Clomid clomiphene Related Articles
Breast Cancer
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
What you should know about breast cancer
- Breast cancer is the most common cancer among American women.
- One in every eight women in the United States develops breast cancer.
- There are many types of breast cancer that differ in their capability of spreading (metastasize) to other body tissues.
- The causes of breast cancer are unknown, although medical professionals have identified a number of risk factors.
- There are many different types of breast cancer.
- Breast cancer symptoms and signs include
- a lump in the breast or armpit,
- bloody nipple discharge,
- inverted nipple,
- orange-peel texture or dimpling of the breast's skin (peau d'orange),
- breast pain or sore nipple,
- swollen lymph nodes in the neck or armpit, and
- a change in the size or shape of the breast or nipple.
- Breast cancer can also be symptom free, which makes following national screening recommendations an important practice.
- Breast cancer is diagnosed during a physical exam, by a self-exam of the breasts, mammography, ultrasound testing, and biopsy.
- Treatment of breast cancer depends on the type of cancer and its stage (0-IV) and may involve surgery, radiation, or chemotherapy.
Young Women & Breast Cancer
Is breast cancer genetic? Should I get tested for the BRCA gene? What every young women should know about breast cancer. Discover the signs and symptoms of breast cancer and other crucial breast cancer facts.Breast Cancer Slides
Learn about breast cancer causes, symptoms, tests, recovery, and prevention. Discover the types of treatments such as surgery and drug therapies as well as the survival rate for breast cancer.Breast Cancer Quiz
This Breast Cancer Quiz features signs, symptoms, facts, causes, common forms, terms, risk factors, statistics, and more. Increase your awareness of breast cancer now!Chemotherapy Treatment for Breast Cancer
Chemotherapy refers to medications that are administered to kill or slow the growth of cancerous cells. Chemotherapy may be given orally or intravenously. Side effects of breast cancer chemotherapy may include nausea, vomiting, hair loss, increased risk of infection, fatigue, and easy bruising. Receiving chemotherapy causes changes in a woman's menstrual cycle.clomiphene, Clomid
Clomiphene (Clomid) is a drug prescribed to stimulate ovulation in women with ovulatory dysfunction who are not pregnant, do not have abnormal bleeding or ovarian cysts, and have normal liver function. Side effects, drug interactions, and dosing information should be reviewed prior to taking this medication.Infertility
Infertility is the diminished ability to conceive a child. Infertility can be a problem with both men and women. Infertility in men can be caused by medical conditions, unhealthy habits, and toxins from the environment. Infertility in women can be caused by problems with ovarian function, the Fallopian tubes, or the physical characteristics of the uterus. Methods of conceiving for couples that cannot conceive include intrauterine inseminations (IUIs) or in vitro fertilization (IVF), specific drugs, assisted reproductive technology (ART), surgery, and gestational carrier.Infertility Quiz
What is the medical definition of infertility? Take the Infertility Quiz to learn the risks and treatment of infertility. Our answers may surprise you!Infertility Treatment
Learn about fertility options such as IVF (in vitro fertilization), acupuncture, and natural lifestyle choices. Read about infertility in men and women as well as treatment costs and pregnancy success rates.letrozole (Femara)
Letrozole (Femara) is a drug prescribed for the treatment of postmenopausal women with hormone receptive positive early breast cancer or who have been treated with tamoxifen (Nolvadex). Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.Pregnancy Test
There are two types of pregnancy tests. One is done in the doctor's office, and tests the blood for the pregnancy hormone, hCG. The other type of pregnancy test can be bought over-the-counter and checks the urine for this hormone. There are many types of home pregnancy tests to choose from. Accuracy of home pregnancy tests depend on how, when, and who uses them, and the brand. It is possible to have a false-negative with a home pregnancy test.Breast Cancer Treatment by Stage
Treatment of breast cancer depends upon the stage of the cancer at the time of diagnosis. Some of the various treatments include:
- hormone therapy,
- radiation therapy,
- surgery,
- chemotherapy,
- HER2-targeted therapy,
- neoadjuvant therapy, and
- adjuvant therapy.