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- What is felodipine, and how does it work?
- What is felodipine used for?
- What are the side effects of felodipine?
- What is the dosage for felodipine?
- Which drugs, supplements, or foods interact with felodipine?
- Is it safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is felodipine, and how does it work?
- nifedipine (Procardia, Adalat)
- amlodipine (Norvasc)
- nisoldipine (Sular)
- nicardipine (Cardene)
- isradipine (Dynacirc)
Calcium is necessary for muscle cells to contract. Felodipine prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand. Dilation of arteries reduces blood pressure. It has little or no effect on the muscles of veins or the heart.
What brand names are available for felodipine?
Plendil is the brand name available for this drug in the US.
What are the side effects of felodipine?
The most common side effects reported by patients include:
- Peripheral edema (swollen ankles and feet)
- Increased heart rate
- Low blood pressure
Other important side effects include:
What is the dosage for felodipine?
- The recommended dose of felodipine is 2.5-10 mg once daily.
- It should be taken without food or with no more than a light meal since food may reduce its absorption.
- Since felodipine comes as a sustained-release tablet, it should be swallowed whole. It should not be chewed or crushed.
Which drugs, supplements, or foods interact with felodipine?
- Cimetidine (Tagamet), ketoconazole (Nizoral, Extina, Xolegel, Kuric), itraconazole (Sporanox), and erythromycin can block the breakdown of felodipine, resulting in higher blood concentrations of felodipine and drops in blood pressure.
- Carbamazepine (Tegretol), phenobarbital, or phenytoin (Dilantin) can lower felodipine blood concentrations. Therefore, higher doses of felodipine may be necessary in patients receiving these medications.
- Taking felodipine with grapefruit juice increases its absorption and may lead to sudden drops in blood pressure.
- Felodipine may increase blood concentrations of tacrolimus (Prograf). Tacrolimus blood concentrations should be monitored and the dose should be modified as necessary.
Is it safe to take if I'm pregnant or breastfeeding?
- There aren't any adequate studies on the effects of felodipine in ppregnant women. Animal studies have shown adverse effects. Therefore, your doctor or health care professional must weigh the potential risks to the fetus against the potential benefits to the you.
- We don't know if felodipine is excreted in breast milk.
What else should I know about this drug?
- It's available as tablets (extended Release) in 2.5, 5, and 10 mg
- You should keep the tablets stored below 86 F (30 C) and protect them from light and moisture.
- Felodipine was approved by the FDA in 1991.
Latest High Blood Pressure News
Daily Health News
Felodipine (Plendil) is a drug prescribed for the treatment of high blood pressure to prevent heart attack and stroke. Doctors also prescribe it to treat patients for angina, however, it is not an FDA approved drug for this condition.
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Related Disease Conditions
How the Heart Works: Sides, Chambers, and Function
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms, including left arm pain and chest pain, are well known but other, more nonspecific symptoms may be associated with a heart attack. Nausea, vomiting, malaise, indigestion, sweating, shortness of breath, and fatigue may signal a heart attack. Heart attack symptoms and signs in women may differ from those in men.
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Omega-3 Fatty Acids
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Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a heart attack than men. High cholesterol, high blood pressure, obesity, and high triglycerides are contributors to heart disease. Some of the common symptoms of a heart attack in women include chest pain, shortness of breath, nausea, feeling faint or woozy, and more. Heart disease can be prevented by lifestyle changes and controlling high blood pressure, cholesterol, weight, and diseases such as diabetes.
Stress and Heart Disease
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Heart Attack Treatment
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Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women and health professionals are not aware of the risk factors for heart disease in women and may delay diagnosis and treatment. Lifestyle factors such as diet, exercise, tobacco use, overweight/obesity, stress, alcohol consumption, and depression influence heart disease risk in women. High blood pressure, high cholesterol, and diabetes also increase women's risk of heart disease. Electrocardiogram (EKG or ECG), stress-ECG, endothelial testing, ankle-brachial index (ABI), echocardiogram, nuclear imaging, electron beam CT, and lab tests to assess blood lipids and biomarkers of inflammation are used to diagnose heart disease. Early diagnosis and treatment of heart disease in women saves lives. Heart disease can be prevented and reversed with lifestyle changes.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back. Women experience the same symptoms as men; however, they also may experience: Extreme fatigue Pain in the upper abdomen Dizziness Fainting Leading a healthy lifestyle with a heart healthy low-fat diet, and exercise can help prevent heart disease and heart attack.
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include losing consciousness, shaking, moving limbs on both sides of the body, and lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are interconnected and affect your risk for heart disease or heart attack. For better heart health, avoid the following: fried foods, hard margarine, commercial baked goods, most packaged and processed snack foods, high fat dairy, and processed meats such as bacon, sausage, and deli meats. Antioxidants and exercise also play a key role in heart attack and heart disease prevention. Lower your risk factors for heart disease and heart attack by: lowering cholesterol, lowering blood pressure, diabetes prevention, and smoking cesssation. Here are a few things you can do to prevent heart attacks: Eat whole, natural, fresh foods, eat five to 10 servings of fruits and vegetables daily, eat more omega-3 fatty acids, drink water, tea, non-fat dairy and red wine, eat lean proteins, limit glycemic foods, and exercise daily.
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries. Learn how to quit smoking today, to prolong your life.
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart Association. Risk factors and symptoms of heart disease in women differ from those in men. Treatment may include lifestyle modification (diet, exercise, weight management, smoking cessation, stress reduction), medications, percutaneous intervention procedure (PCI), and coronary artery bypass grafting (CABG). Heart disease is reversible with treatment.
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause of heart failure. The process of developing atherosclerosis (hardening of the arteries) begins early in life. Heart attack prevention should begin in childhood because the atherosclerosis process can not be reversed. The risk of having a heart attack increases if you have diseases or conditions such as high blood pressure, diabetes, and other heart conditions. You can lowering your risk of having a heart attack by: Lifestyle changes, for example: Diet Exercise Quit smoking Control high blood pressure, diabetes, and other diseases that are risk factors) In some cases, medication is the most effective way of preventing a heart attack
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- nicardipine, Cardene, Cardene SR
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