- Rheumatoid Arthritis Slideshow Pictures
- Take the RA Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is etodolac, and how does it work (mechanism of action)?
- Is etodolac available as a generic drug?
- Do I need a prescription for etodolac?
- What are the side effects of etodolac?
- What is the dosage for etodolac?
- Is etodolac safe to take if I'm pregnant or breastfeeding?
- What else should I know about etodolac?
What is etodolac, and how does it work (mechanism of action)?
Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin, Advil, Nuprin, etc.), naproxen (Aleve, Naprosyn), indomethacin (Indocin), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins which are chemicals that are responsible for pain and the fever and tenderness that often occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved etodolac in January 1991.
What are the side effects of etodolac?
The most common side effects from etodolac are:
- ringing in the ears,
- abdominal pain,
- fluid retention, and
- shortness of breath.
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Etodolac also may cause stomach and intestinal bleeding and ulcers. Sometimes, stomach ulceration and intestinal bleeding can occur without any abdominal pain. Black, tarry stools, weakness, and dizziness upon standing may be the only signs of the bleeding. People who are allergic to other NSAIDs should not use etodolac. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impairment of kidney function or congestive heart failure, and treatment with NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to etodolac and other NSAIDs.
Other important side effects of NSAIDs include:
Quick GuideRheumatoid Arthritis (RA) Symptoms & Treatment
What is the dosage for etodolac?
The recommended doses for general pain relief when using immediate release capsules or tablets are 200-400 mg every 6-8 hours.
Arthritis is managed with 600-1000 mg given in 2 or 3 divided doses daily.
The maximum recommended dose is 1000 mg daily. Total daily doses exceeding 1000 mg have not been adequately evaluated; however, some patients may benefit from a total daily dose of 1200 mg.
The recommended dose when using extended relief tablets is 400-1000 mg once daily. Doses above 1200 mg have not been evaluated.
Etodolac should be taken with food and 8-12 oz of water to avoid stomach related side effects.
Is etodolac safe to take if I'm pregnant or breastfeeding?
It is not known whether etodolac is excreted in human milk.
What else should I know about etodolac?
What preparations of etodolac are available?
- Capsules: 200 and 300 mg;
- Tablets: 400 and 500 mg;
- Extended Release: 400, 500 and 600 mg.
How should I keep etodolac stored?
Capsules and tablets of etodolac should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
Etodolac (Lodine ([Discontinued]) is a NSAID prescribed to treat pain and inflammation associated with osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, tendinitis, bursitis, and menstrual cramps. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Ankylosing Spondylitis Quiz: Symptoms & Treatment
What is ankylosing spondylitis? Take this quiz to learn the causes, symptoms, and treatments for this painful disorder....
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Related Disease Conditions
Menstruation (menstrual cycle) is also referred to as a "period." When a woman menstruates, the lining of the uterus is shed....
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee...
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness...
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints,...
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within...
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also...
Shoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition....
Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing...
Polymyalgia rheumatica (PMR) is a disorder of the muscles and joints that causes pain and stiffness in the arms, neck, shoulders,...
Bursitis of the knee results when any of the three fluid-filled sacs (bursae) become inflamed due to injury or strain. Symptoms...
A bursa is a fluid-filled sac found in the joints that cushions them. Bursitis is an inflammation of the bursae, most commonly...
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms include painful, stiff, and swollen joints,...
Menstrual cramps (pain in the belly and pelvic area) are experienced by women as a result of menses. Menstrual cramps are not the...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of...
Menstrual Cramps and Premenstrual Syndrome (PMS) Medication Guide
Menstrual cramps and premenstrual syndrome (PMS) symptoms include abdominal cramping, bloating, a feeling of fullness, abdominal...
Juvenile Idiopathic Arthritis (Juvenile Rheumatoid Arthritis)
Juvenile idiopathic arthritis (juvenile rheumatoid arthritis or JRA) annually affects one child in every thousand. There are six...
Calcific bursitis is the calcification of the bursa caused by chronic inflammation of the bursa. Calcific bursitis most commonly...
Treatment & Diagnosis
- Pain FAQs
- Ankylosing Spondylitis FAQs
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Tramadol: for Pain (Ultram, Ultram ER, Conzip)
- meloxicam (Mobic) Side Effects
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- celecoxib (Celebrex)
- Drugs: What You Should Know About Your Drugs
- Drug Interactions
- nabumetone, Relafen (Discontinued)
- Aspirin vs. NSAIDs (Side Effect and Use Differences)
- flurbiprofen (Ansaid is a discontinued brand)
- oxaprozin, Daypro
- diflunisal, Dolobid
- fenoprofen, Nalfon
- ketoprofen (Discontinued brands: Nexcede, Orudis, Oruvail, Actron)
- valdecoxib, Bextra
Prevention & Wellness
Daily Health News
Subscribe to MedicineNet's Arthritis Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top etodolac Related Articles
Ankle Pain and TendinitisAnkle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
Ankylosing SpondylitisAnkylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise.
Ankylosing SpondylitisWhat is ankylosing spondylitis? Take this quiz to learn the causes, symptoms, and treatments for this painful disorder.
ArthritisArthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Knee BursitisBursitis of the knee results when any of the three fluid-filled sacs (bursae) become inflamed due to injury or strain. Symptoms include pain, swelling, warmth, tenderness, and redness. Treatment of knee bursitis depends on whether infection is involved. If the knee bursa is not infected, knee bursitis may be treated with ice compresses, rest, and antiinflammatory and pain medications.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
MenstruationMenstruation (menstrual cycle) is also referred to as a "period." When a woman menstruates, the lining of the uterus is shed. This shedding of the uterine linking is the menstrual blood flow. The average menstrual cycle is 28 days. There can be problems with a woman's period, including heavy bleeding, pain, or skipped periods. Causes of these problems may be amenorrhea (lack fo a period), menstrual cramps (dysmenorrhea), or abnormal vaginal or uterine bleeding. There are a variety of situations in which a girl or woman should see a doctor about her menstrual cycle.
OsteoarthritisOsteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Take the Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
Polymyalgia RheumaticaPolymyalgia rheumatica (PMR) is a disorder of the muscles and joints that causes pain and stiffness in the arms, neck, shoulders, and buttocks. Treatment for polymyalgia rheumatica aims to reduce inflammation with aspirin, ibuprofen, and low doses of cortisone medications.
Rheumatoid ArthritisRheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.
Shoulder BursitisShoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition. Symptoms include pain, swelling, tenderness, and pain with movement of the shoulder joint. Treatment may involve ice compresses, rest, and anti-inflammatory medications and depends on whether there is an infection.