- What brand names are available for estropipate?
- Is estropipate available as a generic drug?
- Do I need a prescription for estropipate?
- What are the side effects of estropipate?
- What is the dosage for estropipate?
- Which drugs or supplements interact with estropipate?
- Is estropipate safe to take if I'm pregnant or breastfeeding?
- What else should I know about estropipate?
- What is estropipate, and how does it work (mechanism of action)?
What are the side effects of estropipate?
Common side effects include break-through vaginal bleeding or spotting, loss of periods or excessively prolonged periods, breast pain, breast enlargement, and changes in sexuality (increased or decreased libido). Abdominal pain may result from obstruction of the gallbladder due to gallstones caused by the estrogen. Migraine headaches have been associated with estrogen therapy. Estrogens can cause sodium and fluid retention leading to swelling in the legs (edema). Melasma - tan or brown patches - may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped. Estrogens may cause an increase in the curvature of the cornea, and patients with contact lenses may develop intolerance to their lenses. Estrogens may increase risk of developing DVTs (deep vein thrombosis or blood clot) and endometrial cancer.
Quick GuideMenopause & Perimenopause: Symptoms, Signs
What is the dosage for estropipate?
The usually recommended dose for treating menopause is 0.75 to6 mg orally daily; cycling is 21 days on the medication followed by about 7- 10 days not taking the drug. The dose for osteoporosis prevention is 0.75 mg daily for 25 days then off for 6 days.
Which drugs or supplements interact with estropipate?
: Estrogens can inhibit the metabolism of cyclosporine, resulting in increased cyclosporine levels in blood. Such increased blood levels can result in kidney and/or liver damage. If this combination cannot be avoided, cyclosporine concentrations can be monitored, and the dose of cyclosporine can be adjusted to assure that its blood levels are not elevated.
Estrogens appear to increase the risk of liver disease in patients receiving dantrolene through an unknown mechanism. Women over 35 years of age and those with a history of liver disease are especially at risk. Estrogens increase the liver's ability to manufacture clotting factors. Because of this, patients receiving warfarin (Coumadin) need to be monitored for loss of the anticoagulant (blood thinning) effect of warfarin if estrogens like estropipate are added.
Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone (Mysoline), all can increase the elimination of estrogens by enhancing the liver's ability to metabolize (break down) the estrogens. Thus, concurrent use of these drugs and estrogens may result in reduction of the beneficial effects of estrogens.
Is estropipate safe to take if I'm pregnant or breastfeeding?
Estrogens are secreted in breast milk and cause unpredictable effects in the infant. They generally are not recommended for nursing mothers.
What else should I know about estropipate?
What preparations of estropipate are available?
Tablets: 0.75, 1.5, 3, and 6 mg or 0.625, 1.25 or 2.5, depending on the drug manufacturer.
How should I keep estropipate stored?
Tablets should be stored below 25 C (77 F).
Quick GuideMenopause & Perimenopause: Symptoms, Signs
What is estropipate, and how does it work (mechanism of action)?Estropipate is a form of estrogen, a female sex hormone necessary for many processes in the body. It is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. It is also used to prevent osteoporosis.
Medically reviewed by John Cunha, DO
Reference: FDA Prescribing Information
Estropipate (Ogen, ORTHO-EST) is a form of estrogen prescribed for the treatment of menopausal symptoms such as hot flashes and vaginal dryness as well as to prevent bone fractures associated with osteoporosis. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
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Medications & Supplements
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- Drug Interactions
- estradiol, Alora, Climara, Delestrogen, Depo-Estradiol, Divigel, Elestrin, Estrace, and Others
- Evista (raloxifene)
- estrogens conjugated, Premarin
- conjugated equine estrogens and medroxyprogesterone acetate, Prempro, Premphase
- esterified estrogens, Estratab (discontinued); Menest
Quick GuideMenopause & Perimenopause: Symptoms, Signs
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Reference: FDA Prescribing Information
Top estropipate Related ArticlesComplete List
Alternative Treatments for Hot FlashesHot flashes are experienced by many women, especially at night. However, not all women undergoing menopause experience hot flashes. What causes hot flashes? A hot flash is a feeling of warmth that spreads over the body. Treatment for hot flashes include hormone replacement therapy and alternative prescription medications such as:
- SSRIs (Effexor, Paxil, Prozac),
- clonidine (Catapres),
- megestrol (Megace),
- and gabapentin (Neurontin).
Broken Bone (Types of Bone Fractures)A broken bone is a fracture. There are different types of fractures, such as:
- vertebral compression,
- compound, and
conjugated equine estrogens and medroxyprogesteronconjugated equine estrogens and medroxyprogesterone acetate (Prempro, Premphase) is a medication prescribed for women who are experiencing symptoms associated with menopause such as hot flashes, vaginal dryness, vaginal atrophy, uterine bleeding. Prempro and Premphase are also prescribed for the treatment of osteoporosis. Side effects, dosage, drug interactions, and patient safety information should be reviewed prior to taking this medication.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
esterified estrogensesterified estrogens (Estratab [discontinued]; Menest) are proscribed for treating the common symptoms of menopause, dysfunctional uterine bleeding, female castration, female hypogonadism, prostate cancer, and breast cancer. Side effects, drug interactions, warnings and precautions, and pregnancy information should be reviewed prior to taking any medication.
estradiolEstradiol (Alora; Climara; Delestrogen; Depo-Estradiol; Divigel; Elestrin; Estrace; Estrasorb; Estrogel; Evamist; Femring; Menostar; Minivelle; Vivelle; Vivelle-Dot) is a drug prescribed to treat the symptoms of menopause, prevention of bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness and atrophy associated with menopause. Estradiol is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Side effects, drug interactions, patient information, and dosage should be reviewed prior to taking this medication.
estrogens conjugatedEstrogens (Premarin) are prescribed for the treatment of the symptoms of menopause. Side effects, drug interactions, pregnancy safety, and warnings and precautions should be reviewed prior to taking this medication.
Hot flashes (or flushing) is the most common symptom experienced by a woman prior to and during the early stages of menopause, and often is described as the feeling of warmth that spreads over the body, often starting at the head accompanied by sweating. In the Study of Women Across America the Nation (SWAN) women had hot flashes that lasted on average 7 1/2 years. Symptoms of hot flashes include:
- Excessive sweating
Diagnosis is made by taking a patient history and, at times, blood tests. Treatment options include hormone therapy, bioidentical hormone therapy, and medications. There are non-FDA approved natural home remedies such as:
- Black cohosh
- Evening primrose oil
- Wild yam
- Dong quai
Hot flashes also can be caused by other conditions. Scientific studies to prove the safety and effectiveness of these products in relieving hot flashes have not been adequately performed. Consult your health-care professional before taking any herbal supplement.
MenopauseMenopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies, and should be discussed with your physician.
Menopause QuizThe Menopause Quiz challenges your knowledge about the time in a womanâ€™s life when menstruation ceases. Menopause can bring many physical, mental and sexual challenges to maturing women, but they donâ€™t have to be limiting. Take the Menopause Quiz to learn the causes, symptoms and treatments of whatâ€™s known as â€śthe change of life.â€ť
Menopause SlideshowWhat is menopause? What are the signs of menopause? What age does menopause start? Learn about menopause and perimenopause symptoms. Find the latest treatments for menopause.
Menopause and SexMenopause is often associated with a change in sexual functioning. Loss of estrogen, bladder control issues, anxiety, stress, health concerns, medications, and sleep disturbances often result in a decrease in libido. Though there are currently no good drugs for treating sexual problems in women, there are ways to increase intimacy with a partner and treat vaginal dryness.
OsteoporosisLearn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
Osteoporosis QuizWhat are the causes, symptoms, and risk factors of osteoporosis? Quiz yourself about vitamin deficiency, maintaining bone density, and preventing osteoporosis-related fractures.
Premature Menopause (Medical Procedural Causes)Premature menopause is when menopause occurs in a woman before the age of 40. Causes of premature menopause include premature ovarian failure, treatments for cancer and other conditions, surgical removal of the ovaries, or chronic diseases of the pituitary or thyroid gland, or psychiatric disorders. Treatment is directed at menopausal symptoms.
Evista (raloxifene) is a medication that is prescribed for the treatment and prevention of osteoporosis in postmenopausal women. Black box warnings for Evista includes
- an increased risk of deep vein thrombosis (DVT),
- pulmonary embolism, and
Other side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
Normal vaginal bleeding (menorrhea) occurs through the process of menstruation. Abnormal vaginal bleeding in women who are ovulating regularly most commonly involves excessive, frequent, irregular, or decreased bleeding. Causes of abnormal may arise from a variety of conditions that may include:
- Uterine fibroids
- Pelvic inflammatory disease
- Emotional stress
- Anorexia nervosa
- Polycystic ovary syndrome (PCOS)
- Early pregnancy
The treatment for abnormal or irregular vaginal bleeding depends upon the cause.