- What is estrogens conjugated, synthetic, and how does it work (mechanism of action)?
- What brand names are available for estrogens conjugated, synthetic?
- Is estrogens conjugated, synthetic available as a generic drug?
- Do I need a prescription for estrogens conjugated, synthetic?
- What are the side effects of estrogens conjugated, synthetic?
- What is the dosage for estrogens conjugated, synthetic?
- Is estrogens conjugated, synthetic safe to take if I'm pregnant or breastfeeding?
- What else should I know about estrogens conjugated, synthetic?
What is estrogens conjugated, synthetic, and how does it work (mechanism of action)?
Cenestin is a combination of nine estrogens. Estrogens are hormones produced by the ovaries that are necessary for the proper development of the female reproductive system and sexual characteristics. After menopause, there is a decrease in the amount of estrogen that is produced by the ovaries. This decrease in estrogen production is responsible for hot flashes, mood changes, sleep disturbance, decreased sexual function and other symptoms associated with menopause. Estrogen deficiency also has been linked to heart disease and bone loss (osteoporosis). Cenestin is similar to conjugated estrogens (Premarin), the other drug used for treating hot flashes. Unlike the estrogens in Premarin which are obtained from natural sources and blended to approximate the composition of estrogens found in urine of pregnant horses, the estrogens in Cenestin are synthetic (man- made) and are produced from plant material. Therefore, the estrogens in Cenestin are different from the estrogens found in Premarin. The FDA approved Cenestin in March 1999.
What are the side effects of estrogens conjugated, synthetic?
Common side effects of conjugated estrogens are:
- abdominal pain,
- back pain,
- joint pain and
- vaginal bleeding.
Other important side effects are:
- vaginal spotting,
- loss of periods or
- excessively prolonged periods,
- breast pain,
- breast enlargement, and
- an increase or decrease in sexual drive.
In the eyes, conjugated estrogens may cause an increase in the curvature of the cornea, and, as a result, patients with contact lenses may develop intolerance to their contact lenses.
Estrogens may increase calcium levels in the blood (hypercalcemia) in patients with breast and bone cancer. Some patients may experience increased blood pressure and triglyceride levels.
There is an increased risk of cholesterol gallstones among men and women taking estrogens.
Estrogens also may inhibit the flow of bile from the liver (cholestasis) and uncommonly cause jaundice.
Estrogens can cause salt (sodium) and water retention (edema). Therefore, patients with heart failure or reduced function of their kidneys who are taking estrogens should be carefully observed for retention of water and its complications.
Blood clots in the legs or lungs occasionally occur in women taking conjugated estrogens. This potentially serious complication of estrogen therapy is dose-related, that is, it occurs more commonly with higher doses. Therefore, the lowest effective doses that relieve symptoms should be used. Cigarette smokers are at a higher risk for blood clots. Therefore, patients requiring estrogen therapy should quit smoking.
Estrogens can promote a build up of the lining of the uterus (endometrial hyperplasia) and increase the risk of endometrial cancer. (Women who have undergone surgical removal of the uterus (hysterectomy) are not susceptible to endometrial hyperplasia.) The addition of a progestin to estrogen therapy prevents the development of endometrial cancer.
The Women's Health Initiative found that postmenopausal women (50-79 years old) taking conjugated estrogens, 0.625 mg daily, in combination with medroxyprogesterone, 2.5 mg daily, for five years, had an increased risk of heart attacks, stroke, breast cancer, and blood clots, while postmenopausal women taking conjugated estrogens without progesterone experienced only increased strokes but not increased blood clots, heart disease, or breast cancer.
There was an increased risk of impaired cognition and/or dementia among women over age 65 treated with either estrogens or estrogens and medroxyprogesterone.
What is the dosage for estrogens conjugated, synthetic?
The lowest effective dose should be used, starting with 0.45 mg and gradually increasing to 1.25 mg a day for treatment of hot flashes and 0.3 mg for treatment of vulvar and vaginal atrophy.
Is estrogens conjugated, synthetic safe to take if I'm pregnant or breastfeeding?
Estrogens such as Cenestin may decrease the quantity and quality of breast milk and produce unpredictable effects in the infant. Nursing mothers should avoid taking estrogens.
What else should I know about estrogens conjugated, synthetic?
What preparations of estrogens conjugated, synthetic are available?
Tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg
How should I keep estrogens conjugated, synthetic stored?
Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
- From a Lock of Hair, Beethoven's Genome Gives Clues to Health, Family
- Feds Propose Overhaul of U.S. Organ Transplant System
- New Parasite Is Killing Sea Otters, and Might Pose Threat to People
- When Kids Lose a Parent, New Therapy Might Prevent Long-Term Mental Harm
- New Technique 80% Effective in Selecting a Baby's Gender
- More Health News »
Estrogens conjugated synthetic (Cenestin) is a combination of estrogens prescribed for the relief of moderate to severe hot flashes and vaginal atrophy. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Menopause & Perimenopause: Symptoms, Signs
What is menopause? What are the signs of menopause? What age does menopause start? Learn about menopause and perimenopause...
Women's Health: 25 Hormone Imbalance Symptoms and Signs
Hormone imbalance involves changes in estrogen, progesterone, and other hormone levels. Hormonal imbalance in women may cause...
Menopause Quiz: Symptoms & Signs
The Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many...
Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms and signs include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies and should be discussed with your physician.
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known. Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping. Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
Perimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop symptoms of declining estrogen levels that may include mood swings, painful sex, night sweats, hot flashes, and weight gain. Every adult woman eventually will experience perimenopause.
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
What Are the Benefits of Taking Estrogen?
Estrogen therapy, also known as hormone replacement therapy, is a treatment for alleviating the symptoms caused by menopausal transition. Estrogen therapy can alleviate symptoms like hot flashes, painful intercourse and bone loss.
Vaginal Dryness and Vaginal Atrophy
Vaginal dryness and vaginal atrophy occurs in women during perimenopause, menopause, and postmenopause. With vaginal atrophy, the lining of the vaginal wall becomes thinner, drier, less elastic, and light pink to bluish in color. Symptoms of vaginal atrophy include vaginal dryness, itching, irritation, and/or pain during intercourse. Treatment options for vaginal dryness and vaginal atrophy include hormone treatment and over-the-counter vaginal lubricating and moisturizing products.
Sex and Menopause
Menopause is often associated with a change in sexual functioning. Loss of estrogen, bladder control issues, anxiety, stress, health concerns, medications, and sleep disturbances often result in a decrease in libido. Though there are currently no good drugs for treating sexual problems in women, there are ways to increase intimacy with a partner and treat vaginal dryness.
Sexual health information including birth control, impotence, herpes, sexually transmitted diseases, staying healthy, women's sexual health concerns, and men's sexual health concerns. Learn about the most common sexual conditions affecting men and women.
Treatment & Diagnosis
- Menopause FAQs
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- esterified estrogens and methyltestosterone, Estratest, Estratest HS
- estrogens conjugated (Premarin)
- Conjugated Estrogens (Cenestin, Enjuvia, Estrace, and Others)
- esterified estrogens (Menest)
- conjugated equine estrogens and medroxyprogesterone acetate, Prempro, Premphase
- Side Effects of Cenestin (conjugated estrogens)
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information