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- What is estrogens conjugated, synthetic, and how does it work (mechanism of action)?
- What brand names are available for estrogens conjugated, synthetic?
- Is estrogens conjugated, synthetic available as a generic drug?
- Do I need a prescription for estrogens conjugated, synthetic?
- What are the side effects of estrogens conjugated, synthetic?
- What is the dosage for estrogens conjugated, synthetic?
- Is estrogens conjugated, synthetic safe to take if I'm pregnant or breastfeeding?
- What else should I know about estrogens conjugated, synthetic?
What is estrogens conjugated, synthetic, and how does it work (mechanism of action)?
Cenestin is a combination of nine estrogens. Estrogens are hormones produced by the ovaries that are necessary for the proper development of the female reproductive system and sexual characteristics. After menopause, there is a decrease in the amount of estrogen that is produced by the ovaries. This decrease in estrogen production is responsible for hot flashes, mood changes, sleep disturbance, decreased sexual function and other symptoms associated with menopause. Estrogen deficiency also has been linked to heart disease and bone loss (osteoporosis). Cenestin is similar to conjugated estrogens (Premarin), the other drug used for treating hot flashes. Unlike the estrogens in Premarin which are obtained from natural sources and blended to approximate the composition of estrogens found in urine of pregnant horses, the estrogens in Cenestin are synthetic (man- made) and are produced from plant material. Therefore, the estrogens in Cenestin are different from the estrogens found in Premarin. The FDA approved Cenestin in March 1999.
What are the side effects of estrogens conjugated, synthetic?
Common side effects of conjugated estrogens are:
Other important side effects are:
- vaginal spotting,
- loss of periods or
- excessively prolonged periods,
- breast pain,
- breast enlargement, and
- an increase or decrease in sexual drive.
Estrogens can cause salt (sodium) and water retention (edema). Therefore, patients with heart failure or reduced function of their kidneys who are taking estrogens should be carefully observed for retention of water and its complications.
Blood clots in the legs or lungs occasionally occur in women taking conjugated estrogens. This potentially serious complication of estrogen therapy is dose-related, that is, it occurs more commonly with higher doses. Therefore, the lowest effective doses that relieve symptoms should be used. Cigarette smokers are at a higher risk for blood clots. Therefore, patients requiring estrogen therapy should quit smoking.
Estrogens can promote a build up of the lining of the uterus (endometrial hyperplasia) and increase the risk of endometrial cancer. (Women who have undergone surgical removal of the uterus (hysterectomy) are not susceptible to endometrial hyperplasia.) The addition of a progestin to estrogen therapy prevents the development of endometrial cancer.
The Women's Health Initiative found that postmenopausal women (50-79 years old) taking conjugated estrogens, 0.625 mg daily, in combination with medroxyprogesterone, 2.5 mg daily, for five years, had an increased risk of heart attacks, stroke, breast cancer, and blood clots, while postmenopausal women taking conjugated estrogens without progesterone experienced only increased strokes but not increased blood clots, heart disease, or breast cancer.
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Is estrogens conjugated, synthetic safe to take if I'm pregnant or breastfeeding?
Estrogens such as Cenestin may decrease the quantity and quality of breast milk and produce unpredictable effects in the infant. Nursing mothers should avoid taking estrogens.
What else should I know about estrogens conjugated, synthetic?
What preparations of estrogens conjugated, synthetic are available?
Tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg
How should I keep estrogens conjugated, synthetic stored?
Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
Reference: FDA Prescribing Information
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conjugated equine estrogens and medroxyprogesteronconjugated equine estrogens and medroxyprogesterone acetate (Prempro, Premphase) is a medication prescribed for women who are experiencing symptoms associated with menopause such as hot flashes, vaginal dryness, vaginal atrophy, uterine bleeding. Prempro and Premphase are also prescribed for the treatment of osteoporosis. Side effects, dosage, drug interactions, and patient safety information should be reviewed prior to taking this medication.
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esterified estrogensesterified estrogens (Estratab [discontinued]; Menest) are proscribed for treating the common symptoms of menopause, dysfunctional uterine bleeding, female castration, female hypogonadism, prostate cancer, and breast cancer. Side effects, drug interactions, warnings and precautions, and pregnancy information should be reviewed prior to taking any medication.
esterified estrogens and methyltestosteroneEsterified estrogens and methyltestosterone (Estratest [discontinued], Covaryx, Covaryx H.S., EEMT HS, EEMT) is a mixture of different types of estrogens and methyltestosterone used to treat a variety of medical conditions in women. Therapy with this medication can promote development of and help maintain sexual characteristics and function. Estrogen therapy may also reduce the risk of heart attack, stroke, high cholesterol, hot flashes, and hip fracture due to osteoporosis. Side effects, drug interactions, warnings and precautions, and pregnancy information should be reviewed prior to taking this medication.
estrogens conjugatedEstrogens (Premarin) are prescribed for the treatment of the symptoms of menopause. Side effects, drug interactions, pregnancy safety, and warnings and precautions should be reviewed prior to taking this medication.
estrogens-oralConjugated Estrogens (Cenestin, Enjuvia, Estrace, and Others) is a class of drug that comprises mixtures of man-made natural estrogens to be prescribed as a source of replacement for the natural female hormone. Side effects, drug interactions, dosage, storage, and risks should be reviewed prior to taking conjugated estrogens.
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Menopause QuizThe Menopause Quiz challenges your knowledge about the time in a womanâ€™s life when menstruation ceases. Menopause can bring many physical, mental and sexual challenges to maturing women, but they donâ€™t have to be limiting. Take the Menopause Quiz to learn the causes, symptoms and treatments of whatâ€™s known as â€śthe change of life.â€ť
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Migraine headaches are severe headaches that are sensitive to light, sounds, and smells. Some people who suffer from migraines also have severe head pain. People also have symptoms of nausea and vomiting. Common migraine triggers may include:
- Certain foods
- Changes in barometric pressure
- Other phenomenon
They are diagnosed by a doctor if the headache pattern fits established migraine headache criteria. Over-the-counter (OTC) and prescription medications are sometime used to treat acute migraines. To prevent or reduce the frequency and severity of them doctors recommend supplements and prescription medications, for example:
- Blood pressure drugs
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Lifestyle modification helps in migraine management. Many people who suffer from migraines get relief from their condition by keeping a headache diary, identifying and avoiding triggers, and taking appropriate medication.
OsteoporosisLearn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
PerimenopausePerimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop symptoms of declining estrogen levels that may include mood swings, painful sex, night sweats, hot flashes, and weight gain. Every adult woman eventually will experience perimenopause.
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