- What is estrogens conjugated, and how does it work (mechanism of action)?
- What brand names are available for estrogens conjugated?
- Is estrogens conjugated available as a generic drug?
- Do I need a prescription for estrogens conjugated?
- What are the side effects of estrogens conjugated?
- What is the dosage for estrogens conjugated?
- Which drugs or supplements interact with estrogens conjugated?
- Is estrogens conjugated safe to take if I'm pregnant or breastfeeding?
- What else should I know about estrogens conjugated?
What is estrogens conjugated, and how does it work (mechanism of action)?
Estrogens are one of the two major classes of female hormones. (Progestins comprise the second major class). Estrogens are used primarily to treat the symptoms of menopause and states in which there is a deficiency of estrogen, for example, in women who have had their ovaries removed. Conjugated estrogens are a mixture of several different estrogens (estrogen salts) that are derived from natural sources and blended to approximate the composition of estrogens in the urine of pregnant horses. The main components are sodium estrone sulphate and sodium equilin sulfate.
Estrogens have widespread effects on many tissues in the body. Estrogens cause growth and development of the female sexual organs and maintain female sexual characteristics such as the growth of underarm and pubic hair, body contours, and skeleton. Estrogens also increase secretions from the cervix and growth of the inner lining of the uterus (endometrium).
What are the side effects of estrogens conjugated?
Common side effects of conjugated estrogens are:
Other side important effects include:
- vaginal spotting,
- loss of periods or
- excessively prolonged periods,
- breast pain,
- breast enlargement and
- an increase or decrease in sexual drive.
Estrogens can cause salt (sodium) and water retention (edema). Therefore, patients with heart failure or reduced function of their kidneys who are taking estrogens should be carefully observed for retention of water and its complications.
Blood clots in the legs or lungs occasionally occur in women taking conjugated estrogens. This potentially serious complication of estrogen therapy is dose-related, that is, it occurs more commonly with higher doses. Therefore, the lowest effective doses that relieve symptoms should be used.
Estrogens can promote a build up of the lining of the uterus (endometrial hyperplasia) and increase the risk of endometrial cancer. (Women who have undergone surgical removal of the uterus--hysterectomy--are not susceptible to endometrial hyperplasia.) The addition of a progestin to estrogen therapy prevents the development of endometrial cancer.
The Women's Health Initiative found that postmenopausal women (50-79 years old) taking conjugated estrogens, 0.625 mg daily, in combination with medroxyprogesterone, 2.5 mg daily, for five years, had an increased risk of heart attacks, stroke, breast cancer, and blood clots, while postmenopausal women taking conjugated estrogens without progesterone experienced only increased strokes but not increased blood clots, heart disease, or breast cancer.
What is the dosage for estrogens conjugated?
To minimize side effects, the lowest effective oral dose of conjugated estrogens is used. The usual starting dose for treating symptoms associated with menopause and for preventing postmenopausal osteoporosis is 0.3 mg/day. The dose should be increased based on response.
Conjugated estrogens may be administered continuously or in a cyclical fashion (i.e., 25 days on treatment then 5 days off treatment).
Hypogonadism is treated cyclically with doses of 0.3 mg or 0.625 mg daily for 25 days followed by 5 days off treatment.
The dose for women who have had their ovaries removed or have ovarian failure is 1.25 mg daily for three weeks followed by one week off treatment. In reality, most women take estrogens continuously since during the week off treatment, symptoms return because of the lack of estrogen.
For treatment of breast cancer, the recommended dose is 10 mg daily for three months. Abnormal uterine bleeding due to hormonal imbalance is treated with one 25 mg intravenous or intramuscular injection. Another injection may be given in 6-12 hours if needed.
The vaginal cream is used for treating vulvar and vaginal atrophy, and the recommended dose is ½ to 2 g daily.
Which drugs or supplements interact with estrogens conjugated?
Estrogens increase the liver's ability to manufacture factors that promote the clotting of blood. Because of this, patients receiving warfarin (Coumadin), a drug that thins the blood and prevents clotting by reducing clotting factors, need to be monitored for loss of the blood thinning effect if treatment with an estrogen is begun.
Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), griseofulvin (Grifulvin), phenytoin (Dilantin), St. John's wort, and primidone all increase the elimination of estrogen by enhancing the liver's ability to eliminate estrogens. Use of any of these medications with estrogens may result in a reduction of the beneficial effects of estrogens.
Conversely, drugs such as erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), and ritonavir (Norvir) may reduce the elimination of estrogens by the liver and lead to increased levels of estrogens in the blood.
Grapefruit juice also may increase levels of estrogen by increasing the absorption of estrogens from the intestine. Increased levels of estrogens in the blood may result in more estrogen-related side effects.
Is estrogens conjugated safe to take if I'm pregnant or breastfeeding?
Estrogens should not be given to pregnant women due to the risk of harm to the fetus.
Estrogens are secreted in breast milk and may cause unpredictable effects in the infant. Estrogens may also reduce the quality of breast milk. They should not be taken by women who are breastfeeding.
What else should I know about estrogens conjugated?
What preparations of estrogens conjugated are available?
Tablets: 0.3, 0.45, 0.625, 0.9, and 1.25 mg. Vaginal cream: 0.625 mg per gm of cream. Injection: 25 mg per vial
How should I keep estrogens conjugated stored?
Conjugated estrogen tablets and cream should be stored at room temperature, between 15 C -30 C (59 F - 86 F). The injection should be stored between 2 C - 8 C (36 F - 46 F).
Estrogens (Premarin) are prescribed for the treatment of the symptoms of menopause. Side effects, drug interactions, pregnancy safety, and warnings and precautions should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Menopause & Perimenopause: Symptoms, Signs
What is menopause? What are the signs of menopause? What age does menopause start? Learn about menopause and perimenopause...
Menopause Quiz: Symptoms & Signs
The Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many...
Women’s Health: 13 Hormone Imbalance Symptoms and Signs
Hormone imbalance involves changes in estrogen, progesterone, and other hormone levels. Hormonal imbalance may cause symptoms...
Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause...
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on...
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone...
Perimenopause (Symptoms, Signs, Remedies, and Treatments)
Perimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop...
Cholesterol (Lowering Your Cholesterol)
High cholesterol and triglyceride levels increase the risk of cardiovascular disease. Getting your cholesterol and triglyceride...
Menstrual cramps (pain in the belly and pelvic area) are experienced by women as a result of menses. Menstrual cramps are not the...
Vaginal dryness and vaginal atrophy occurs in women during perimenopause, menopause, and postmenopause. With vaginal atrophy, the...
Hepatic hemangiomas are referred to as tumors, however, they not malignant and do not become cancerous. Hemangiomas can occur in...
Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
Pseudotumor Cerebri (intracranial hypertension) is a condition where there is an increase in pressure of fluid surrounding the...
Sexual health information including birth control, impotence, herpes, sexually transmitted diseases, staying healthy, women's...
Treatment & Diagnosis
- Menopause FAQs
- What are granulomatosis with polyangiitis and erythema nodosum?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Osteoporosis - EVISTA..... Wellness for Women?
- Osteoporosis Prevention & Treatment
- Osteoporosis Prevention & Treatment - Exercise & Estrogen
- Osteoporosis Prevention & Treatment - Medications, Fluoride, Monitoring
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Medication Disposal
- Dangers of Mixing Medications
- What Are Hypercoagulable States?
- Herbs: Toxicities and Drug Interactions
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drug Interactions
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Evista (raloxifene)
- estradiol, Alora, Climara, Delestrogen, Depo-Estradiol, Divigel, Elestrin, Estrace, and Others
- estropipate, Ogen
- conjugated estrogens vaginal cream, Premarin Vaginal Cream
- conjugated equine estrogens and medroxyprogesterone acetate, Prempro, Premphase
- esterified estrogens (Menest)
- Conjugated Estrogens (Cenestin, Enjuvia, Estrace, and Others)
Prevention & Wellness
Women's Health Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information