- What is esterified estrogens, and how does it work (mechanism of action)?
- What brand names are available for esterified estrogens?
- Is esterified estrogens available as a generic drug?
- Do I need a prescription for esterified estrogens?
- What are the side effects of esterified estrogens?
- What is the dosage for esterified estrogens?
- Which drugs or supplements interact with esterified estrogens?
- Is esterified estrogens safe to take if I'm pregnant or breastfeeding?
- What else should I know about esterified estrogens?
What is esterified estrogens, and how does it work (mechanism of action)?
Esterified estrogens are a mixture of several estrogens, a type of female hormone. Estrogens cause growth and development of female sex organs and the maintenance of sex characteristics, including growth of underarm and pubic hair and shaping of body contours and skeleton. Estrogens also increase secretions from the cervix and promote growth of the inner lining of the uterus (endometrium).
What are the side effects of esterified estrogens?
The most common endocrine side effects are
- bleeding or spotting,
- loss of periods, or
- excessively prolonged periods,
- breast pain,
- breast enlargement, and
- changes in sexuality (increase or decrease in libido).
Other important side effects include:
Melasma (tan or brown patches) may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped. Estrogens may cause an increase in the curvature of the cornea, and, therefore, patients with contact lenses may develop intolerance to their lenses.
What is the dosage for esterified estrogens?
The dose for menopause and related conditions is 0.3 to 1.25 mg daily for 3 weeks then 1 week off. Female hypogonadism is treated with 2.5 to 7.5 mg daily for 20 days then 10 days off. Breast cancer is treated with 10 mg three times daily for at least 3 months and the dose for prostate cancer is 1.25 to 2.5 mg 3 times daily.
Which drugs or supplements interact with esterified estrogens?
Estrogens increase the liver's ability to manufacture proteins that are required for blood to clot. Therefore, patients receiving warfarin (Coumadin), which reduces clotting ("thins" the blood) by inhibiting the production of proteins required for clotting, should receive clotting tests if an estrogen is added to their treatment. If blood clots too easily, the dose of warfarin may need to be increased.
Rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone can increase the elimination of estrogen by enhancing the liver's ability to metabolize (destroy) it. Use of these drugs may result in a reduction of the beneficial effects of estrogens. Conversely, drugs such as erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), and ritonavir (Norvir) may reduce the elimination of estrogens by the liver and lead to increased levels of estrogens in the blood. Grapefruit juice also may increase levels of estrogen by increasing the absorption of estrogens from the intestine. Increased levels of estrogens in the blood may result in more estrogen-related side effects.
Is esterified estrogens safe to take if I'm pregnant or breastfeeding?
Estrogens should not be used during pregnancy because of an increased risk of fetal abnormalities.
Estrogens are secreted in milk and cause unpredictable effects in the infant. Therefore, they generally should not be used during breastfeeding.
What else should I know about esterified estrogens?
What preparations of esterified estrogens are available?
Tablets: 0.3, 0.625, 1.25, and 2.5 mg.
How should I keep esterified estrogens stored?
Tablets should be stored between 2 C (36 F) and 30 C (86 F).
Quick GuideMenopause & Perimenopause: Symptoms, Signs
Esterified estrogens (Estratab [discontinued]; Menest) are prescribed for treating the common symptoms of menopause, dysfunctional uterine bleeding, female castration, female hypogonadism, prostate cancer, and breast cancer. Side effects, drug interactions, warnings and precautions, and pregnancy information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast...
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone...
Prostate cancer is the most common cancer in men after skin cancer. Risk factors include age, family history, ethnicity, and...
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause...
Normal vaginal bleeding (menorrhea) occurs through the process of menstruation. Abnormal vaginal bleeding in women who are...
Sexual health information including birth control, impotence, herpes, sexually transmitted diseases, staying healthy, women's...
Sex and Menopause (What to Expect)
Menopause is often associated with a change in sexual functioning. Loss of estrogen, bladder control issues, anxiety, stress,...
Perimenopause (Symptoms, Signs, Remedies, and Treatments)
Perimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop...
Hot Flashes (Causes, Symptoms & Medication Treatment in Men and Women)
Hot flashes (or flushing) is the most common symptom experienced by a woman prior to and during the early stages of menopause,...
Vaginal dryness and vaginal atrophy occurs in women during perimenopause, menopause, and postmenopause. With vaginal atrophy, the...
Treatment & Diagnosis
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- What Are Hypercoagulable States?
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- estradiol, Alora, Climara, Delestrogen, Depo-Estradiol, Divigel, Elestrin, Estrace, and Others
- estrogens conjugated (Premarin)
- conjugated equine estrogens and medroxyprogesterone acetate, Prempro, Premphase
- estropipate, Ogen
- Evista (raloxifene)
- esterified estrogens and methyltestosterone, Estratest, Estratest HS
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Conjugated Estrogens (Cenestin, Enjuvia, Estrace, and Others)
Prevention & Wellness
Women's Health Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information