Essential Mixed Cryoglobulinemia: Symptoms & Signs

Medically Reviewed on 3/8/2021

Cryoglobulinemia is a medical condition that is caused by proteins in the blood called cryoglobulins. Cryoglobulins are abnormal proteins that by definition have the property of precipitating from the serum when it is chilled in the laboratory and then dissolving back into the serum upon rewarming. Cryoglobulins may or may not cause disease.

Signs and symptoms of essential mixed cryoglobulinemia include

The condition can also lead to nerve disease, kidney disease, heart attack, and bleeding in the lungs.

Cause of essential mixed cryoglobulinemia

When the cryoglobulin proteins are a mixture of various antibody types (mixed), and the cause is unknown (essential), the condition is referred to as essential mixed cryoglobulinemia.

Other essential mixed cryoglobulinemia symptoms and sign

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References
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.