What is Eraxis, and how does it work?
What are the side effects of Eraxis?
Common side effects of Eraxis include:
- flushing or hot flashes,
- vomiting, or
- injection site reactions (pain, swelling, or irritation).
Tell your doctor if you have serious side effects of Eraxis including
- shortness of breath,
- dark urine,
- severe stomach or abdominal pain,
- yellowing eyes or skin,
- persistent nausea or vomiting,
- muscle weakness or spasm,
- vision changes,
- pain/redness/swelling of arms or legs,
- new signs of infection (e.g., fever, persistent sore throat),
- easy bruising or bleeding,
- fast/slow/irregular heartbeat,
- increased urination or thirst, or
- mental/mood changes.
What is the dosage for Eraxis?
Recommended Dosage In Adults
Candidemia And Other Candida Infections (Intra-Abdominal Abscess And Peritonitis)
The recommended dose is a single 200 mg loading dose of Eraxis on Day 1, followed by a 100 mg once daily maintenance dose thereafter. Duration of treatment should be based on the patient’s clinical response. In general, antifungal therapy should continue for at least 14 days after the last positive culture.
The recommended dose is a single 100 mg loading dose of Eraxis on Day 1, followed by a 50 mg once daily maintenance dose thereafter. Patients should be treated for a minimum of 14 days and for at least 7 days following resolution of symptoms. Duration of treatment should be based on the patient’s clinical response. Because of the risk of relapse of esophageal candidiasis in patients with HIV infection, suppressive antifungal therapy may be considered after a course of treatment.
Recommended Dosage In Pediatric Patients (1 Month Of Age And Older)
Candidemia And Other Candida Infections (Intra-Abdominal Abscess And Peritonitis)
The recommended dose is a single loading dose of 3 mg/kg (not to exceed 200 mg) of Eraxis on Day 1, followed by a once daily maintenance dose of 1.5 mg/kg (not to exceed 100 mg) of Eraxis thereafter. Overall antifungal treatment should continue for at least 14 days after the last positive culture.
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What drugs interact with Eraxis?
- Administration of multiple doses of anidulafungin and cyclosporine to healthy subjects resulted in no significant alteration in the steady state pharmacokinetics of either drug.
- No dosage adjustment of cyclosporine or anidulafungin is needed when the two drugs are co-administered.
- Administration of multiple doses of anidulafungin and voriconazole to healthy subjects resulted in no significant alteration in the steady state pharmacokinetics of either drug.
- No dosage adjustment of voriconazole or anidulafungin is needed when the two drugs are co-administered.
- Administration of multiple doses of anidulafungin and a single-dose of tacrolimus to healthy subjects resulted in no significant alteration in the steady state pharmacokinetics of either drug.
- No dosage adjustment of tacrolimus or anidulafungin is needed when the two drugs are co-administered.
- Administration of multiple doses of anidulafungin and rifampin to patients resulted in no significant alteration in the steady state pharmacokinetics of anidulafungin.
- No dosage adjustment of anidulafungin is needed when it is co-administered with rifampin.
Amphotericin B Liposome For Injection
- Administration of multiple doses of anidulafungin and liposomal amphotericin B to patients resulted in no significant alteration in the steady state pharmacokinetics of anidulafungin.
- No dosage adjustment of anidulafungin is needed when it is co-administered with liposomal amphotericin B.
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Is Eraxis safe to use while pregnant or breastfeeding?
- Based on findings from animal studies, Eraxis can cause fetal harm when administered to a pregnant woman.
- There are no available human data on the use of Eraxis in pregnant women to inform a drug-associated risk of adverse developmental outcomes.
- In animal reproduction studies fetal toxicity was observed in the presence of maternal toxicity when anidulafungin was administered to pregnant rabbits during organogenesis at 4 times the proposed therapeutic maintenance dose of 100 mg/day on the basis of relative body surface area.
- Inform pregnant woman of the risk to the fetus.
- There are no data on the presence of anidulafungin in human milk, the effects on the breastfed infant or the effects on milk production.
- The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Eraxis and any potential adverse effects on the breastfed child from Eraxis or from the underlying maternal condition.
Eraxis (anidulafungin) is an antifungal antibiotic that treats candida (yeast) infections in the blood, or in the stomach or esophagus. Common side effects of Eraxis include flushing or hot flashes, dizziness, diarrhea, constipation, headache, nausea, vomiting, or injection site reactions (pain, swelling, or irritation).
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What Is the Main Cause of a Yeast Infection?
Yeast infections are mainly caused by yeast-like fungus named Candida or Monilia. Yeast infections may affect the skin, mouth or vagina. Your doctor will use different methods of testing yeast infections depending on the area of your infection or symptoms.
Vaginal Yeast Infection in Women
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Yeast Infection vs. Diaper Rash in Infants, Toddlers, and Children
Diaper rash in infants, babies, toddlers, and children is caused by Candida, the most common type of fungus. Signs and symptoms of diaper rash is red, elevated skin that may be visible under and in the creases of the skin, groin, or anus. Yeast diaper rash is not painful. Treatments for diaper rash include antibiotic creams, lotions, natural home remedies, over-the-counter (OTC) medicine, and oral antibiotics. Yeast infections in infants, babies, toddlers, and children can cause diaper rash, thrush. Signs and symptoms of thrush include thick, white lacy patches on top of a red base can form on the tongue, palate, or elsewhere inside the palate. Treatment for yeast infections caused by Candida fungi are similar to the treatments for diaper rash. If Candida gets into the blood stream of an individual they may get sick with or without a fever. If the Candida infection spreads throughout the body up to 45% of people may die. Even with common mouth thrush can cause critical illness and may be more resistant to normal treatment.
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Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
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Vaginal yeast infection is also called vaginal candidiasis. It is caused when there is an overgrowth of a germ called Candida albicans that is a normal resident of the vagina.
What Happens if You Don't Treat a Yeast Infection?
Yeast infections are contagious. They can be transmitted through sexual contact. Those with weak immunity have a high risk of the infection. Yeast infections can be vaginal (candidiasis), oral (thrush) or penile. Untreated yeast infections may spread to other areas, cause symptoms or pass to others.
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
Candida auris (C. auris)
Candida auris (C. auris) is a yeast that is resistant to many antifungal medications. Most C. auris infections occur in hospitalized patients. C. auris causes an invasive infection and has a high mortality rate.
Yeast Infection vs. Bacterial Vaginosis (BV)
Yeast infections and bacterial vaginosis (BV) both cause vaginal discharge. Yeast infection discharge is thick, white, and had a cottage cheese consistency. BV discharge is whitish-gray and is thinner. Vaginal odor, irritation, and pain may also be present. Treatment of yeast infections includes over-the-counter and prescription antifungals. BV treatment involves antibiotics.
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