- What is epinephrine injection (Auvi-Q)? What is Auvi-Q used for?
- What are the side effects of epinephrine injection (Auvi-Q)?
- What is the dosage for epinephrine injection (Auvi-Q)?
- Which drugs or supplements interact with epinephrine injection (Auvi-Q)?
- Is epinephrine injection (Auvi-Q) safe to take if I'm pregnant or breastfeeding?
- What else should I know about epinephrine injection?
What is epinephrine injection (Auvi-Q)? What is Auvi-Q used for?
Auvi-Q is an auto-injectable epinephrine-containing device used for self-administration during life-threatening allergic reactions, including anaphylaxis. Auvi-Q is an epinephrine auto-injector that talks the user step by step through the injection process. Epinephrine, the medicine contained in Auvi-Q, is an excitatory chemical naturally made by our bodies. Epinephrine stimulates alpha and beta adrenergic receptors found throughout the body. When injected during an allergic reaction, epinephrine works in multiple ways to treat the many signs of anaphylaxis. It causes blood vessels to constrict or tighten which helps to increase blood pressure and decrease swelling. Epinephrine also stimulates the heart muscle, causing the heart to beat faster and pump more blood to the vital organs. Epinephrine helps patient's breathe better by relaxing the muscles in the lungs and allowing the airways to open up. Additionally, it also helps to prevent further release of inflammatory chemicals that were triggered by the initial allergic reaction.
Auvi-Q was approved by the FDA in 2012.
What brand names are available for epinephrine injection?
Is epinephrine injection Auvi-Q available as a generic drug?
Although auto-injectable epinephrine is available in generic forms, a generic version of Auvi-Q device is currently not available.
Do I need a prescription for epinephrine injection Auvi-Q?
What are the side effects of epinephrine injection (Auvi-Q)?
The most common side effects of Auvi-Q include:
- fast, irregular, or pounding heartbeat;
- vomiting; and
- breathing problems.
Auvi-Q is intended for administration in the muscle or fat tissues in the outer thigh only. Injecting Auvi-Q in other areas of the body including the buttocks, hands, or feet may not provide effective treatment of anaphylaxis and may even cause side effects.
What is the dosage for epinephrine injection (Auvi-Q)?
Auvi-Q is available in two strengths, 0.15 mg and 0.3 mg. The selection of the appropriate strength is based on the patient's body weight. Patients weighing = 30 kg (approximately = 66 pounds) should use Auvi-Q 0.3 mg. Patients weighing 15 to 30 kg (approximately 33 to 66 pounds) should use Auvi-Q 0.15 mg. It is not known if Auvi-Q is safe and effective for use in children weighing less than 15 kg (33 pounds).
Each device contains only 1 dose of medicine and can only be used once. Auvi-Q should be injected into the muscle of the outer thigh. If needed, Auvi-Q may be injected through clothing.
Which drugs or supplements interact with epinephrine injection (Auvi-Q)?
Administration of epinephrine to patients taking cardiac glycosides, diuretics (water pills), or drugs for treating irregular heartbeats (antiarrhythmics) can cause the development of irregular heartbeats.
The effects of epinephrine may be enhanced by medicines such as tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine (Synthroid, Levoxyl), and certain antihistamines.
The treatment benefits of epinephrine can be reduced by beta-adrenergic blocking medicines such as propranolol (Inderal) and alpha-adrenergic blocking medicines such as phentolamine (Regitine, OraVerse).
Some anti-migraine medications may also interfere with the benefits of epinephrine treatment.
Patients should speak with their pharmacist for a complete list of all drug interactions, and check if any of their current medications have any meaningful interactions with Auvi-Q.
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Is epinephrine injection (Auvi-Q) safe to take if I'm pregnant or breastfeeding?
Use of epinephrine has not been adequately evaluated in pregnant women. Use of epinephrine in animal studies was associated with birth defects. Epinephrine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Epinephrine is classified as FDA pregnancy risk category C (animal studies show an adverse effect on the fetus).
It is not known if epinephrine is excreted in breast milk. Since many drugs are excreted in human milk and have the potential of causing harm to the nursing infant, caution should be used when Auvi-Q is administered to a nursing mother.
What else should I know about epinephrine injection?
What preparations of epinephrine injection are available?
Injection: 0.3 mg (0.3 mg/0.3ml) and 0.15 (0.15 mg/0.15 ml) prefilled auto injector.
How should I keep epinephrine injection stored?
Auvi-Q should be stored at room temperature, between 15 C and 30 C (59 F to 86 F). Auvi-Q should not be refrigerated. The medicine contained in Auvi-Q is light sensitive and should be protected from the light. Auvi-Q should always be stored in the outer case provided by the manufacturer.
A self-administered epinephrine injection (Auvi-Q) is a prescription medication used in emergencies by people with severe allergies to halt anaphylaxis. Side effects, drug interactions, and patient safety information should be reviewed prior to taking this medication
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An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Fragrances and preservatives in cosmetics may cause allergic reactions in some people. Symptoms include redness, itching, and swelling after the product comes in contact with the person's skin. Treatment typically involves the use of over-the-counter cortisone creams.
Anaphylaxis is a serious allergic reaction that affects a number of different areas of the body at one time and can be fatal. Causes of anaphylaxis can be a food allergy, latex allergy, allergy to insect stings/bites, asthma, or other materials or conditions. Symptoms include flushing, itching, hives, anxiety, and rapid or irregular pulse. Severe symptoms may be throat and tongue swelling, swallowing, and difficulty breathing. Some disorders appear similar to anaphylaxis such as fainting, panic attacks, blood clots in the lungs, heart attacks, and septic shock. If you think that you may be having an anaphylactic reaction, seek emergency care or call 911 immediately.
Peanut allergies causes signs and symptoms that include hives, itching, redness, and a rash. Severe reactions may cause decreased blood pressure, lightheadedness, difficulty breathing, nausea, and behavioral changes. Someone with a peanut allergy should have an EpiPen with them at all times.
Insect Sting Allergies
The majority of stinging insects in the United States are from bees, yellow jackets, hornets, wasps, and fire ants. Severity of reactions to stings varies greatly. Avoidance and prompt treatment are essential. In selected cases, allergy injection therapy is highly effective.
Drug Allergy (Medication Allergy)
Drug or medication allergies are caused when the immune system mistakenly creates an immune response to a medication. Symptoms of a drug allergic reaction include hives, rash, itchy skin or eyes, dizziness, nausea, diarrhea, fainting, and anxiety. The most common drugs that people are allergic to include penicillins and penicillin type drugs, sulfa drugs, insulin, and iodine. Treatment may involve antihistamines or corticosteroids. An EpiPen may be used for life-threatening anaphylactic symptoms.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.