Epidermolysis bullosa often is apparent by birth or during infancy. Symptoms and signs include
- severe skin fragility,
- erosions, and
- skin blisters.
Other associated signs and symptoms can include
- nails that are thick or don't form,
- blisters inside the mouth and throat,
- thickened skin on the palms and soles of the feet,
- scalp blistering,
- scarring and hair loss (scarring alopecia), or
- thin-appearing skin (atrophic scarring).
Some affected people may have
- tiny white skin bumps or pimples (milia),
- dental problems, such as tooth decay from poorly formed enamel, or
- difficulty swallowing (dysphagia).
Cause of epidermolysis bullosa
Epidermolysis bullosa is caused by one or multiple defective genes that are required to produce structural proteins that are involved in the adherence of the epidermis (the most superficial layer of skin) to the dermis (the deeper layer of the skin).
Other epidermolysis bullosa symptoms and signs
- Blisters Inside the Mouth and Throat
- Dental Problems, Such as Tooth Decay From Poorly Formed Enamel
- Difficulty Swallowing (Dysphagia)
- Nails That Are Thick or Don't Form
- Scalp Blistering
- Scarring and Hair Loss (Scarring Alopecia)
- Thickened Skin on the Palms and Soles of the Feet
- Thin-Appearing Skin (Atrophic Scarring)
- Tiny White Skin Bumps or Pimples (Milia)