Eosinophilic Fasciitis: Symptoms & Signs

Medically Reviewed on 2/22/2021

Eosinophilic fasciitis is a rare disease characterized by inflammation of the skin and fascia, a sheet or band of fibrous connective tissue under the skin that covers a surface of underlying tissues. In eosinophilic fasciitis, the inflammatory cells consist of a particular type of white blood cells known as eosinophils.

Signs and symptoms of eosinophilic fasciitis can include

  • progressive thickening of the skin,
  • redness, warmth, tenderness, and hardening of the skin surface.

This is often seen on the skin of the arms or legs. The skin may take on a puckered appearance. Sometimes, the onset of eosinophilic fasciitis has been described to occur following a period of physical activity.

Cause of eosinophilic fasciitis

While the condition is known to be an inflammatory response, the exact cause of the inflammation is not known.

Other eosinophilic fasciitis symptoms and signs

  • Progressive Thickening of the Skin
  • Puckered Appearance to the Skin
  • Redness, Warmth, Tenderness, and Hardening of the Skin Surface


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.