Generic Name: entacapone
Brand and Other Names: Comtan
Drug Class: Anti-Parkinson Agent, COMT Inhibitor
What is entacapone, and what is it used for?
Entacapone is a prescription medication used together with carbidopa and levodopa to treat “wearing-off” symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
- Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
- People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.
- This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Entacapone may cause you to fall asleep suddenly, even after feeling alert.
- Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
- Avoid drinking alcohol. It can increase some of the side effects of entacapone.
Do not take if you have:
- Hypersensitivity to entacapone
What are the side effects of entacapone?
Common side effects of entacapone include:
- dizziness, drowsiness.
- nausea, vomiting, stomach pain.
- dry mouth; or
- uncontrolled muscle movements.
Serious side effects of entacapone include:
- difficult breathing,
- swelling of the face, lips, tongue, or throat,
- agitation, confusion, unusual thoughts, or behavior,
- hallucinations (hearing or seeing something that is not there);
- very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, light-headedness
- severe or ongoing diarrhea,
- restless muscle movements in the eyes, tongue, jaw, or neck (or worsening of Parkinson’s symptoms); or
- unexplained muscle pain, tenderness, or weakness especially if you also have a fever, unusual tiredness, and dark-colored urine.
Rare side effects of entacapone include:
Seek medical care or call 911 at once if you have the following serious side effects:
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.
This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.
What is the dosage for entacapone?
- 200 mg
- Oral: 200 mg with each dose of levodopa/carbidopa, up to a maximum of 8 times daily (maximum daily dose: 1600 mg daily).
What drugs interact with entacapone?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first
- Entacapone has severe interactions with the following drugs:
- Entacapone has serious interactions with the following drugs:
- metoclopramide intranasal
- ropeginterferon alfa 2b
- Entacapone has moderate interactions with the following drugs:
- Entacapone has minor interactions with no other drugs.
This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products.
Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.
Pregnancy and breastfeeding
Pregnancy and Lactation
- It is not known whether entacapone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Entacapone is a prescription medication used together with carbidopa and levodopa to treat “wearing-off” symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Common side effects of entacapone include dizziness, drowsiness, nausea, vomiting, stomach pain, diarrhea, dry mouth, or uncontrolled muscle movements. Avoid drinking alcohol due to risk of increased side effects. Consult your doctor if pregnant or breastfeeding.
Multimedia: Slideshows, Images & Quizzes
Healthy Aging: Reasons for Memory Loss and Dementia Risk
Forget your keys? That might be absentmindedness. Forget what you did this morning? That might be a more serious memory problem....
Parkinson's Disease: Symptoms, Causes, Stages, Treatment
Discover the symptoms, causes, stages, and treatment options for Parkinson's disease. Learn more about the stages of Parkinson's...
The Stages of Dementia: Alzheimer's Disease and Aging Brains
What are the symptoms of dementia? What causes dementia? Dementia includes many disorders, such as Lewy Body dementia,...
Dementia and Alzheimer's: 13 Bad Brain Health Habits
Good brain health depends on exercising regularly, eating well, and getting enough sleep. Learn how to develop good health habits...
Parkinson's Disease Quiz: Test Your Medical IQ
Parkinson's disease is common among neurodegenerative disorders. Do you know how it works? The causes? The symptoms? Take the...
Picture of Vascular (Multi-Infarct) Dementia 2
There are several types of vascular dementia, which vary slightly in their causes and symptoms. See a picture of Vascular...
Picture of Lewy Body Dementia
Lewy body dementia (LBD) is one of the most common types of progressive dementia. See a picture of Lewy Body Dementia (LBD) and...
Picture of Frontotemporal Dementia (FTD)
Frontotemporal dementia, sometimes called frontal lobe dementia, describes a group of diseases characterized by degeneration of...
Picture of HIV-associated Dementia (HAD)
A 40-year-old woman diagnosed with HIV presented with confusion and decline in memory. See a picture of HIV-associated Dementia...
Picture of Vascular (Multi-Infarct) Dementia 1
Vascular dementia is the second most common cause of dementia, after Alzheimer's disease. See a picture of Vascular...
Dementia and Alzheimer's: Is It Aging or Alzheimer's?
Learn the difference between memory problems that can happen to all of us as we get older and real warning signs of dementia.
Brain Health: Foods that May Lower Dementia Risk
What foods are associated with Alzheimer's disease and other forms of dementia? Cognitive function is predicated on good...
Related Disease Conditions
Dementia is defined as a significant loss of intellectual abilities such as memory capacity, severe enough to interfere with social or occupational functioning. There are several different types of dementia, including cortical, subcortical, progressive, primary, and secondary dementias. Other conditions and medication reactions can also cause dementia. Dementia is diagnosed based on a certain set of criteria. Treatment for dementia is generally focused on the symptoms of the disease.
Parkinson's disease is a slowly progressive neurological disease characterized by a fixed inexpressive face, a tremor at rest, slowing of voluntary movements, a gait with short accelerating steps, peculiar posture and muscle weakness, caused by degeneration of an area of the brain called the basal ganglia, and by low production of the neurotransmitter dopamine. Most patients are over 50, but at least 10 percent are under 40.
What Are the Seven Stages of Lewy Body Dementia?
Lewy body dementia (LBD) or dementia with Lewy bodies (DLB) is associated with protein deposits in the brain that cause disruptions in the normal functioning of the brain. Diagnosing the disease is extremely tough because its symptoms may resemble other brain diseases. There are seven stages of Lewy body dementia.
How Long Does the Final Stage of Dementia Last?
While it is difficult to predict how long the final stage of dementia will last, most patients survive for one to three years.
How Do You Know When a Dementia Patient Is Dying?
When a dementia patient is close to dying, you may notice signs such as agitation, restlessness, moaning, and changes in breathing.
What Is the Difference Between Dementia and Alzheimer's?
Dementia is a group of symptoms (syndrome) characterized by a decline in memory, thinking and reasoning. Although dementia is a cluster of symptoms, Alzheimer’s is a slowly progressive disorder of the brain that destroys memory and thinking skills.
What Are the 5 Stages of Parkinson’s Disease?
Parkinson’s disease (PD) is a progressive neurological disease that affects movement. Learn about symptoms in each of the 5 stages.
What Are the Seven Stages of Dementia?
The progression of dementia (in Alzheimer’s disease) has been divided into seven stages. Learn about treatment, prevention, and foods that can help fight dementia.
Early Warning Signs and Stages of Dementia
Dementia is a decline and or loss of behavior of mental abilities, loss of judgment, language, and reasoning. Early warning signs of dementia include misplacing items, difficulty planning or problem solving, poor work performance, difficulty doing familiar tasks, and withdrawal from social activities. There are seven stages of dementia that range from stage 1, with no cognitive decline to stage 7, which is severe dementia.
Can Parkinson’s Be Reversed With Diet?
Parkinson's disease cannot be reversed with diet, but dietary changes, exercise, and medications can help ease symptoms and slow the progression of the disease.
Can You Be Bipolar With Dementia?
Because bipolar disorders can alter brain structure and chemistry over time, gradual damage to brain cells can lead to symptoms of dementia such as memory loss.
Parkinson's Disease: Eating Right
Eating a well-balanced and nutritional diet is very beneficial to people with Parkinson's disease. With a proper diet, our bodies work more efficiently and it is especially helpful because Parkinson's disease medications will work properly.
What Are the 7 Stages of Dementia?
What are the 7 stages of dementia and how do you recognize them? Learn the signs of dementia and what to do if you or your loved one is showing symptoms of dementia.
What Are the Newest Drugs for Parkinson’s?
Parkinson's disease is a brain disorder that causes movement problems like a slow, shuffling walk, loss of balance and coordination, and tremors. The newest drugs for Parkinson's are adenosine A2a antagonists and other therapies.
What Are 10 Possible Causes of Parkinson's Disease?
Parkinson's disease is a neurological condition that mainly affects your body's movement. The 10 possible causes of Parkinson's disease include genetics, chemical exposure, where you live, and other factors.
How Do You Get Parkinson's Disease?
Parkinson's disease results from a lack of dopamine production in the brain, affecting a person's physical and mental abilities. Learn what the causes and symptoms are of Parkinson's and how to best treat it.
What Mental Illness Is Similar to Dementia? Can It Be Bipolar?
Despite not being classified as a mental illness, here are four mental health disorders often mistaken for dementia due to their similar symptoms.
What Foods Should People With Parkinson’s Disease Avoid?
Diet and nutrition play a significant role in boosting the overall health of people with Parkinson’s disease. Here are 7 foods people with Parkinson’s should avoid.
What Is the Best Treatment for Parkinson’s Disease?
Parkinson's disease is the deterioration of brain nerves that control movement. Learn what medical treatments can help ease your Parkinson's disease symptoms and speed up your recovery.
What Are the 5 Signs of Parkinson's Disease?
Parkinson's disease is an age-related neurodegenerative disorder that leads to a gradual decline of your motor functions. The 5 signs of Parkinson's include tremors, stiffness, balance problems, trouble speaking, and small handwriting.
Is Dystonia a Form of Parkinson's?
Dystonia can be one of the symptoms of Parkinson’s disease (PD). PD is a long-term neurological movement disorder with various symptoms ranging from slowness of movement (bradykinesia), rigidity of muscles, tremor, loss of balance, memory impairment, personality changes and others.
What Is the Most Effective Treatment for Parkinson's?
Parkinson’s disease is a brain disorder that causes movement problems like shaking, slow movements, muscle stiffness, and loss of balance and coordination. The most effective treatment for Parkinson's is levodopa, but there are other medications and treatments available.
16 Early Signs of Dementia
Dementia is a general term for a group of conditions characterized by a decline in memory, thinking and reasoning. The early signs of dementia may vary depending on the cause of dementia. Some of the early signs include a decline in memory, inability to focus, forgetfulness and other symptoms.
What Are the Signs of Early Onset Dementia?
Early onset dementia is rare and difficult to diagnose. Learn about early signs of dementia that may indicate that something is wrong.
What Causes Motor Fluctuations in Parkinson’s Disease?
Motor fluctuations in Parkinson’s disease are caused by drops in dopamine brain levels since your nerve cells can no longer make enough of the chemical.
How Do People Get Parkinson’s?
Parkinson's disease is a chronic age-related brain condition of the nervous system, causing parts of your brain to degenerate. People get Parkinson's due to genetic and environmental factors, age, gender, and other things.
Treatment & Diagnosis
Medications & Supplements
- Your Child Is Sick. Do You Call Your Doctor or Head to the ER?
- Mental Health Care Shortage Could Play Role in U.S. Youth Suicides
- Shopping Black Friday for TVs, Furniture? Don't Forget the Tip-Over Kit
- Keeping Thanksgiving Day Kitchens Safe for the Whole Family
- All the Flavor, Better Health: Holiday Dinner Ingredient Swaps That Work
- More Health News »
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.