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What is Endari, and how does it work?
Endari (L-glutamine oral powder) is used to reduce acute complications of sickle cell disease.
What is the dosage for Endari?
Administer Endari orally, twice per day at the dose based on body weight according to Table 1.
Table 1. Recommended Dosing
|Weight in kilograms||Weight in pounds||Per dose in grams||Per day in grams||Packets per dose||Packets per day|
|less than 30||less than 66||5||10||1||2|
|30 to 65||66 to 143||10||20||2||4|
|greater than 65||greater than 143||15||30||3||6|
Is Endari safe to use while pregnant or breastfeeding?
- There are no available data on Endari use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage.
- Animal reproduction studies were not conducted with Endari.
- There are no data on the presence of Endari in human milk, the effect on the breastfed infant or the effect on milk production.
- The developmental and health benefits from breastfeeding should be considered along with the mother's clinical need for Endari and any potential adverse effects on the breastfed child from Endari or from the underlying maternal condition.
Endari (L-glutamine oral powder) is used to reduce acute complications of sickle cell disease. Side effects of Endari can include enlarged spleen, abdominal pain, dyspepsia, burning sensation, and hot flash.
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Sickle Cell Disease (Anemia)
Sickle cell anemia (sickle cell disease), a blood disease which shortens life expectancy, is caused by an inherited abnormal hemoglobin. Symptoms of sickle cell anemia may include bacterial infections, painful swelling of the hands and feet, fever, leg ulcers, fatigue, anemia, eye damage, and lung and heart injury. Treatment for sickle cell anemia aims to manage and prevent the worst manifestations of the disease and focuses on therapies that block red blood cells from stacking together, which can lead to tissue and organ damage and pain.
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