Endari (L-glutamine oral powder)

Endari (L-glutamine oral powder) is used to reduce acute complications of sickle cell disease.

Administer Endari orally, twice per day at the dose based on body weight according to Table 1.

Table 1. Recommended Dosing

Side effects of Endari can include:

• enlarged spleen,
• abdominal pain,
• dyspepsia,
• burning sensation, and
• hot flash

• There are no available data on Endari use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage.
• Animal reproduction studies were not conducted with Endari.
• There are no data on the presence of Endari in human milk, the effect on the breastfed infant or the effect on milk production.
• The developmental and health benefits from breastfeeding should be considered along with the mother's clinical need for Endari and any potential adverse effects on the breastfed child from Endari or from the underlying maternal condition.