Endari (L-glutamine oral powder)

What is Endari, and how does it work?

Endari (L-glutamine oral powder) is used to reduce acute complications of sickle cell disease.

What is the dosage for Endari?

Administer Endari orally, twice per day at the dose based on body weight according to Table 1.

Table 1. Recommended Dosing

Weight in kilogramsWeight in poundsPer dose in gramsPer day in gramsPackets per dosePackets per day
less than 30less than 6651012
30 to 6566 to 143102024
greater than 65greater than 143153036

What are the side effects of Endari?

Side effects of Endari can include:

What drugs interact with Endari?

No Information Provided

Is Endari safe to use while pregnant or breastfeeding?

  • There are no available data on Endari use in pregnant women to inform a drug-associated risk of major birth defects and miscarriage.
  • Animal reproduction studies were not conducted with Endari.
  • There are no data on the presence of Endari in human milk, the effect on the breastfed infant or the effect on milk production.
  • The developmental and health benefits from breastfeeding should be considered along with the mother's clinical need for Endari and any potential adverse effects on the breastfed child from Endari or from the underlying maternal condition.


Sickle cell disease is named after a farming tool. See Answer


Endari (L-glutamine oral powder) is used to reduce acute complications of sickle cell disease. Side effects of Endari can include enlarged spleen, abdominal pain, dyspepsia, burning sensation, and hot flash.

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