Generic drug: levetiracetam
Brand name: Elepsia XR
What is Elepsia XR (levetiracetam), and how does it work?
What is Elepsia XR and how is it used?
It is not known if Elepsia XR is safe or effective in people under 12 years of age.
What are the side effects of Elepsia XR?
Call your healthcare provider right away if you have any of these symptoms:
- mood and behavior changes such as aggression, agitation, anger, anxiety, apathy, mood swings, depression, hostility, and irritability. A few people may get psychotic symptoms such as hallucinations (seeing or hearing things that are really not there), delusions (false or strange thoughts or beliefs) and unusual behavior.
- extreme sleepiness, tiredness, and weakness
- problems with muscle coordination (problems walking and moving)
- allergic reactions such as swelling of the face, lips, eyes, tongue, and throat, trouble swallowing or breathing, and hives.
- a skin rash. Serious skin rashes can happen after you start taking Elepsia XR. There is no way to tell if a mild rash will become a serious reaction.
Common side effects seen in people who take Elepsia XR:
- nasal congestion, sore throat, and runny nose (nasopharyngitis)
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Elepsia XR. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Elepsia XR?
- Elepsia XR is administered orally once daily.
- Initiate treatment with a dose of 1000 mg once daily. The once daily dosage may be adjusted in increments of 1000 mg every 2 weeks, to a maximum recommended daily dose of 3000 mg/day.
- Elepsia XR should be taken whole; do not split or cut tablets.
Dosage Adjustment In Adult Patients With Renal Impairment
- Elepsia XR is not recommended for use in patients with moderate or severe renal impairment. Recommended doses and adjustment for patients with mild renal impairment are shown in Table 1.
- In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated.
To do this, an estimate of the patient’s creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:
CLcr = [140-age (years)] x weight (kg)
____________________________ (x 0.85 for female patients)
72 x serum creatinine (mg/dL)
Then CLcr is adjusted for body surface area (BSA) as follows:
CLcr (mL/min/1.73m2 ) = CLcr (mL/min)
_______________ x 1.73
BSA subject (m2)
Table 1: Dosing Adjustment Regimen for Adult Patients with Impaired Renal Function
|Normal||greater than 80||1000 to 3000||Every 24 hours|
|Mild||50 to 80||1000 to 2000||Every 24 hours|
Discontinuation Of Elepsia XR
When discontinuing Elepsia XR, reduce the dosage gradually and avoid abrupt discontinuation because of the risk of increased seizure frequency and status epilepticus.
IMAGESBrowse our medical image collection to see examples of MRI brain scans, PET scans, and other imaging techniques used to diagnose and treat brain disorders See Images
Is Elepsia XR safe to use while pregnant or breastfeeding?
- Prolonged experience with levetiracetam in pregnant women has not identified a drug-associated risk of major birth defects or miscarriage, based on published literature, which includes data from pregnancy registries and reflects experience over two decades.
- There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), including Elepsia XR, during pregnancy.
- Women who are taking Elepsia XR during pregnancy should enroll in the North American Antiepileptic Drug (NAAED) pregnancy registry by calling 1-888-233-2334 or visiting http://www.aedpregnancyregistry.org/.
Elepsia XR (levetiracetam) is a prescription medicine taken by mouth that is used with other medicines to treat partial onset seizures in people 12 years of age and older. Common side effects seen in people who take Elepsia XR include flu, sleepiness, irritability, nasal congestion, sore throat, and runny nose (nasopharyngitis), dizziness, and nausea.
Multimedia: Slideshows, Images & Quizzes
What Is Epilepsy? Symptoms, Causes, and Treatments
Learn about epilepsy symptoms and treatment for this seizure condition. Discover the definition of epilepsy, how epilepsy is...
Epilepsy & Seizures Quiz: What Causes Seizures?
Do you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to...
Related Disease Conditions
Migraines and Seizures
Migraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
Seizures: Symptoms and Types
Seizures occur when there is an abnormal burst of electrical activity in the brain and are divided into two categories: generalized and partial. Learn about the symptoms of different types of seizures, and check out the center below for more medical references on seizures, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
What Causes Myoclonic Seizures in Babies?
Epileptic syndromes that cause myoclonic seizures usually begin in early childhood, and last throughout life, though milder forms may improve with adulthood. Doose syndrome (myoclonic-atonic epilepsy), Dravet syndrome (severe myoclonic epilepsy of infancy [SMEI]) and Lennox-Gastaut syndrome are all childhood epilepsy syndromes that may cause seizures in babies and toddlers.
Can the Vagus Nerve Cause Seizures?
The vagus nerve is an important pathway to the brain in addition to helping to control seizures. Stimulation of the vagus nerve leads to the discharge of electrical energy into a wide area of the brain, disturbing the abnormal brain activity that causes seizures. The vagus nerve is used to treat seizures that do not respond to medications.
Seizure vs. Seizure Disorders: What's the Difference?
Seizures and seizure disorders are not the same medical problems. A seizure happens when the electrical activity in the brain is uncontrolled. There are about 40 different types of seizure disorders, in which epilepsy is one. Symptoms depend on the type of disorder, but can include loss of consciousness, uncontrolled twitching or shaking of one side, or the entire body.
Can a Person With Epilepsy Live a Normal Life?
Can a person with epilepsy live a normal life? What is epilepsy and what causes it? Learn the signs and symptoms of epilepsy, what causes it, how doctors diagnose it, and what you can do to treat it.
Epilepsy and Seizures: How to Treat?
A seizure is a sudden, uncontrolled electrical disturbance in the brain. Epilepsy is a neurological disorder where brain activities are abnormal, causing more than one or recurrent episodes of seizures. Most cases of seizures can be managed conservatively with medication and supportive treatments.
What Are the Different Types of Seizures?
A seizure is a sudden change in the brain's normal electrical activity. During a seizure, brain cells fire uncontrollably than their normal rate, temporarily affecting the way a person behaves, moves, thinks, or feels. Recurrent seizures are called epilepsy. Seizures are usually categorized into three types depending on their onset.
Treatment & Diagnosis
- Epilepsy and Seizures FAQs
- What Are the Different Types of Epilepsy?
- Why Remove Half A Brain?
- Seizure Symptoms: How to Assist the Victim
- Seizures: When the Computer Goes Haywire
- Senator Ted Kennedy: Seizure, Brain Cancer, and Death
- Brain Cancer Symptoms: Headaches and Seizures
- Does Lupus Cause Seizures?
- What Is a Jacksonian Seizure?
Medications & Supplements
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.