- What is Zepatier, and how does it work?
- What brand names are available for Zepatier?
- Is Zepatier available as a generic drug?
- Do I need a prescription for Zepatier?
- What are the uses for Zepatier?
- What are the side effects of Zepatier?
- What is the dosage for Zepatier?
- Which drugs or supplements interact with Zepatier?
- Is Zepatier safe to use during pregnancy or while breastfeeding?
- What else should I know about Zepatier?
What is Zepatier, and how does it work?
Zepatier is an oral tablet containing two drugs used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 and 4 in adults. The components belong to a class of drugs called direct-acting antiviral agents. Similar drugs include:
- boceprevir (Victrelis)
- sofosbuvir (Sovaldi)
- simeprevir (Olysio)
- telaprevir (Incivek),
- Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir)
- ledipasvir and sofosbuvir (Harvoni)
Zepatier contains elbasvir and grazoprevir. Elbasvir directly blocks replication of HCV by interfering with a hepatitis C virus enzyme called NS5A. Grazoprevir is an inhibitor of another hepatitis C virus enzyme called NS3/4A, which also is needed for viral replication. Both drugs in Zepatier interfere with enzymes needed by hepatitis C virus to multiply and make new viruses, thus reducing the overall viral load. The efficacy of Zepatier has been established in subjects with hepatitis C virus genotypes 1 and 4.
Zepatier may be administered with or without ribavirin. In clinical studies, 95% of patients who were not previously treated for their hepatitis C virus were cured after 12 weeks of Zepatier treatment. Cure was defined as undetectable levels of hepatitis C virus in the blood when measured three months after the completion of treatment. The FDA approved Zepatier in January, 2016.
What are the uses for Zepatier?
What are the side effects of Zepatier?
Common side effects include:
Other side effects include:
What is the dosage for Zepatier?
- The recommended dose of Zepatier is one tablet daily with or without food for 12 to 16 weeks.
- The duration of treatment depends on whether patients have been previously treated with ribavirin and interferon for their HCV, the presence or absence of treatment-resistant HCV, and the type of HCV infection. Patients should be tested for the presence of resistant HCV prior to starting treatment to determine the correct dosage and duration of treatment.
- The recommended duration of treatment for most patients is 12 weeks. Those who fall into the following two categories are treated for 16 weeks:
- People with genotype 1a infection, treatment-naive or previously treated with peginterferon and ribavirin, and have resistant viruses: 16 weeks treatment.
- People with genotype 4 infection and previously treated with peginterferon (Pegasys) and ribavirin: 16 weeks treatment.
Which drugs or supplements interact with Zepatier?
Zepatier has many drug interactions, for example:
Rifampin and St. John's wort may reduce blood levels of Zepatier by increasing its metabolism (break-down) in the intestine. Therefore, Zepatier should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of Zepatier include:
- nafcillin (Nafcil)
- bosentan (Tracleer)
- carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol)
- phenytoin (Dilantin, Dilantin-125)
- phenobarbital, oxcarbazepine (Tripetal)
- rifampin, tipranavir (Aptivus)
- ritonavir (Norvir)
- efavirenz (Sustiva)
- atazanavir (Reyataz)
- darunavir (Prezista)
- lopinavir/ritonavir (Kaletra)
- saquinavir (Invirase)
- etravirine (Intelence)
- modafanil (Provigil)
Combining Zepatier with cyclosporine or ketoconazole may increase the risk of liver enzyme elevations because cyclosporine increases blood levels of grazoprevir. Zepatier should not be combined with cyclosporine.
Zepatier increases blood levels of atorvastatin (Lipitor), rosuvastatin (Crestor), and possibly other statins. The dose of atorvastatin should not exceed a daily dose of 20 mg and the dose of Crestor should not exceed 10 mg daily when they are combined with Zepatier.
Is Zepatier safe to use during pregnancy or while breastfeeding?
What else should I know about Zepatier?
What preparations of Zepatier are available?
- Tablets (elabsvir and grazoprevir): 50/100 mg
How should I keep Zepatier stored?
- This drug should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
Subscribe to MedicineNet's General Health Newsletter
Zepatier (elbasvir and grazoprevir) is a combination of two drugs prescribed as one medication that cures some forms of the otherwise incurable hepatitis C virus. Though the drug has several side effects, for example:
Ninety-five percent of patients in a clinical trial were still virus-free three months after treatment. The drug works, in part, by attacking the ability of the hepatitis C virus to replicate.
Multimedia: Slideshows, Images & Quizzes
Hepatitis C Quiz: What is Hepatitis C?
How many Americans have hepatitis C? Take this quiz to learn the facts about this chronic disease....
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function....
Picture of Liver
Front View of the Liver. The liver is a large, meaty organ that sits on the right side of the belly. See a picture of the Liver...
Hepatitis C, Hep B, Hep A: Symptoms, Causes, Treatment
What is hepatitis? Hepatitis A, B, and C spread in different ways, causing mild to serious effects on the liver. Learn about...
Hepatitis: How Do You Get Hepatitis A, B, and C?
Hepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver...
Hepatitis C (Hep C) Symptoms and Treatment
What is Hepatitis C (Hep C, HVC)? Learn about hepatitis c symptoms, how you get hepatitis c, contagiousness, and hepatitis C...
Related Disease Conditions
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation,...
Hepatitis (Viral Hepatitis, A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or...
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion,...
Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as: gallstones, high...
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like: fatigue,...
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of...
Hepatitis C Cure (Symptoms, Transmission, Treatments, and Cost)
Hepatitis is inflammation of the liver. There are a variety of toxins, diseases, illicit drugs, medications, bacterial and viral...
Treatment & Diagnosis
- Liver Disease FAQs
- Hepatitis C FAQs
- IBS, GERD, Hepatitis C: Doctors Dialogue
- How common is Hepatitis C?
- How is diagnosis of Hepatitis C made?
- Hepatitis C : Can it be sexually transmitted?
- Hepatitis C: What blood tests?
- Hepatitis C genotypes
- Hepatitis C Treatments
- Hepatitis C: Most effective treatment
- Hepatitis C: Reasons for treating
- Hepatitis C: Interferon/ribavarin side effects
- Hepatitis C: Good candidates for treatment
- Do you treat hepatitis C patients with normal liver tests?
- Hepatitis C: Not Good Candidates for Treatment?
- Hepatitis C: Diet and Vitamins
- Hepatitis C: Should patients receive immunizations
- Hepatitis C treatment relapse
- What to do for relapsers after hepatitis C treatment?
- Hepatitis C: What is unique about hepatitis C?
- Hepatitis C News Release
- Hepatitis C: Nightmare in Vegas
Medications & Supplements
Prevention & Wellness
- Experimental Drug Combo Shows Promise Against Hepatitis C
- Antiviral Combination Approved for Hepatitis C
- Drug Regimen Cures Hepatitis C in Most Liver Transplant Patients in Study
- Alcohol Fuels Liver Disease in Those With HIV and Hepatitis C
- FAQ: The High Cost of Hepatitis C Drugs
- Cure Rate for Experimental Hepatitis C Drug Tops 95 Percent
- FDA Approves New Treatment for Hepatitis C Infection
- Baby Boomers Need Hepatitis C Test, CDC Study Confirms
- Experimental Drug for Hepatitis C Promising, Studies Show
- Experimental Drug May Work Against Hepatitis C
- Drug Users Are 'Super-Spreaders' of Hepatitis C, Study Finds
- 'Boomers' With Hepatitis C Boosting Demand for Liver Transplants
- Antiviral Therapy for Hepatitis C May Thwart Liver Cancer
- CDC: All Baby Boomers Should Get Screened for Hepatitis C
- Many Homeless May Harbor Hepatitis C
- CDC: All Baby Boomers Should Get Tested for Hepatitis C
- 'Explosion' of Sex-Spread Hepatitis C in HIV-Positive Men
- Experts Propose Age-Based Hepatitis C Testing
- Adding Third Drug May Improve Hepatitis C Treatment
- Many Kids With Hepatitis C Are Missed
- Experimental Drug May Treat Hepatitis C
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.