efinaconazole, Jublia

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Toenail fungus

What is efinaconazole Jublia, and how does it work (mechanism of action)?

: Efinaconazole is a topical (applied to the skin) antifungal used for the local treatment of fungal infections of the toenails. Efinaconazole destroys fungal cells by inhibiting fungal lanosterol 14α-demethylase, an enzyme required to make ergosterol, an important fungal cell wall component. Without cell walls fungus cannot survive. Efinaconazole was approved by the FDA in June, 2014.

What brand names are available for efinaconazole Jublia?

Jublia

Is efinaconazole Jublia available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for efinaconazole Jublia?

: Yes

What are the side effects of efinaconazole Jublia?

: The most common side effects of treatment are mainly irritation of the area(s) efinaconazole is applied to. Side effects include:

Quick GuideNail Color and Texture: What Nails Say About Your Health

Nail Color and Texture: What Nails Say About Your Health

What is the dosage for efinaconazole Jublia?

: Efinaconazole is applied to the affected toenail(s) once daily for 48 weeks. When applying efinaconazole, patients should make sure that the toenails, toenail beds, and surrounding skin are completely covered. For best results, apply efinaconazole to dry toenails. Patients should wait for at least 10 minutes after showering, bathing, or washing before applying efinaconazole. Patients should avoid pedicures, use of nail polish, or cosmetic nail products while using efinaconazole. Efinaconazole is only intended for use on toenails and surrounding skin.

The safety and effectiveness of efinaconazole has not been established in pediatric patients.

Which drugs or supplements interact with efinaconazole Jublia?

: No known drug interaction has been identified with efinaconazole.

Is efinaconazole Jublia safe to take if I'm pregnant or breastfeeding?

NURSING MOTHERS: It is not known if efinaconazole is excreted in breast milk. As many drugs are excreted in human milk and have the potential of harming the nursing infant, efinaconazole should be used cautiously in nursing mothers.

What else should I know about efinaconazole Jublia?

What preparations of efinaconazole Jublia are available?

PREPARATIONS: Topical solution: 10%

How should I keep efinaconazole Jublia stored?

STORAGE: Efinaconazole should be stored at room temperature, from 15 C to 30 C (59 C to 86 F). Efinaconazole is flammable and should be protected from heat or flames. Efinaconazole containers should be stored in an upright position. Keep efinaconazole and all medications out of the reach of children.

REFERENCE: FDA Prescribing Information

Quick GuideNail Color and Texture: What Nails Say About Your Health

Nail Color and Texture: What Nails Say About Your Health

Summary

Efinaconazole (Jublia) is an antifungal cream applied to the toenails and surrounding skin to treat toenail fungus. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking any medication.

Treatment & Diagnosis

Prevention & Wellness

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Reviewed on 3/13/2015
References
REFERENCE: FDA Prescribing Information

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