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- What is dutaseride? How does it work (mechanism of action)?
- What are the uses for dutasteride?
- What are the side effects of dutasteride?
- What is the dosage for dutasteride?
- Which drugs or supplements interact with dutasteride?
- Is dutasteride safe to take if I'm pregnant or breastfeeding?
- What else should I know about dutasteride?
What is dutaseride? How does it work (mechanism of action)?
Dutasteride is a medication used for the treatment of benign prostatic hyperplasia (BPH) also known as an enlarged prostate. Dutasteride belongs to a class of medication called 5-alpa reductase inhibitors. Male hormone dihydrotestosterone (DHT) is primarily responsible for development and enlargement of the prostate gland. Testosterone is converted into DHT by 5-alpha reductase enzyme. Dutasteride blocks 5-alpha reductase enzyme and prevents excessive DHT production in the prostate gland. This delays the progression of an enlarged prostate and improves symptoms of BPH.
The FDA approved dutasteride in November 2001.
What are the side effects of dutasteride?
Dutasteride causes many sexual side effects.
Common side effects are:
Allergic reaction such as swelling under the skin may occur. Dutasteride also increases risk of high-grade prostate cancer. Patients must contact their healthcare professional if unusual reactions to dutasteride occur.
What is the dosage for dutasteride?
The recommended dose of dutasteride is 0.5 mg once daily. Do not chew the medication and do not administer to pediatric patients.
Which drugs or supplements interact with dutasteride?
Medications such as ketoconazole (Nizoral), cimetidine (Tagamet), diltiazem (Cardizem), verapamil (Calan), ritonavir (Norvir) and clarithromycin (Biaxin) slow down the breakdown of dutasteride. This may lead to increased levels of dutasteride in the body, increasing side effects such as decreased libido, erectile dysfunction, and impotence.
Medications such as carbamazepine (Tegretol) and primidone (Mysoline) increase the breakdown of dutasteride in the body. This may lead to decreased levels of dutasteride in the body, lowering the beneficial effects of the medication.
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Is dutasteride safe to take if I'm pregnant or breastfeeding?
It is not known whether dutasteride enters breast milk.
What else should I know about dutasteride?
What preparations of dutasteride are available?
Dutasteride is available as 0.5 mg liquid-filled capsules.
How should I keep dutasteride stored?
Dutasteride capsules should be stored between 15 C to 30 C (59 F to 86 F).
Dutasteride is available in generic form, but must be prescribed by a doctor or other health-care professional. The brand name available for dutaseride is Avodart.
Dutasteride (Avodart) is a prescription drug used to treat benign prostatic hyperplasia (BPH, enlarged prostate). Side effects, drug interactions, dosage, storage information, and pregnancy safety should be reviewed prior to taking this medication.
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Prostatitis (Inflammation of the Prostate Gland)
Prostatitis is an inflammation of the prostate gland. Signs and symptoms of prostatitis include painful or difficulty urinating; fever; chills; body aches; blood in the urine; pain in the rectum, groin, abdomen, or low back; and painful ejaculation or sexual dysfunction. Causes of prostatitis include STDs, bacteria from urinary tract infections, or E. coli. Treatment for prostatitis depends on if it is a bacterial infection or chronic inflammation of the prostate gland.
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Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Benign prostatic hyperplasia (BPH or enlarged prostate) is very common in men over 50 years of age. Half of all men over the age of 50 develop symptoms of BPH, but few need medical treatment. This noncancerous enlargement of the prostate can impede urine flow, slow the flow of urine, create the urge to urinate frequently and cause other symptoms like complete blockage of urine and urinary tract infections. More serious symptoms are urinary tract infections (UTIs) and complete blockage of the urethra, which may be a medical emergency. BPH is not cancer. Not all men with the condition need treatment, and usually is closely monitored if no symptoms are present. Treatment measures usually are reserved for men with significant symptoms, and can include medications, surgery, microwave therapy, and laser procedures. Men can prevent prostate problems by having regular medical checkups that include a prostate exam.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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