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What is Dupixent, and what is it used for?
Dupixent is a prescription medicine used:
- to treat people aged 12 years and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. Dupixent can be used with or without topical corticosteroids.
- with other asthma medicines for the maintenance treatment of moderate-to-severe asthma in people aged 12 years and older whose asthma is not controlled with their current asthma medicines. Dupixent helps prevent severe asthma attacks (exacerbations) and can improve your breathing. Dupixent may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing.
- Dupixent works by blocking two proteins that contribute to a type of inflammation that plays a major role in atopic dermatitis and asthma.
- Dupixent is not used to treat sudden breathing problems.
- It is not known if Dupixent is safe and effective in children with atopic dermatitis under 12 years of age.
- It is not known if Dupixent is safe and effective in children with asthma under 12 years of age.
What are the side effects of Dupixent?
Dupixent can cause serious side effects, including:
- Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis.
- Eye problems. If you have atopic dermatitis, tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision.
- Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive Dupixent. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by Dupixent. Tell your healthcare provider right away if you have:
Stop using Dupixent and tell your healthcare provider or get emergency help right away if you get any of the following symptoms:
- breathing problems
- general ill feeling
- swollen lymph nodes
- swelling of the face, mouth, and tongue
- fainting, dizziness, feeling lightheaded (low blood pressure)
- joint pain
- skin rash
The most common side effects of Dupixent include:
- injection site reactions
- eye and eyelid inflammation, including redness, swelling, and itching (if you also have atopic dermatitis)
- pain in the throat (oropharyngeal pain)
- cold sores in your mouth or on your lips
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of Dupixent.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage of Dupixent?
Dupixent is administered by subcutaneous injection.
Dosing In Adults
The recommended dose of Dupixent for adult patients is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg given every other week.
Dosing In Adolescents
The recommended dose of Dupixent for patients 12 to 17 years of age is specified in Table 1.
Table 1: Dose of Dupixent for Subcutaneous Administration in Adolescent Patients
|Body Weight||Initial Dose||Subsequent Doses (every other week)|
|less than 60 kg||400 mg (tw o 200 mg injections)||200 mg|
|60 kg or more||600 mg (two 300 mg injections)||300 mg|
Concomitant Topical Therapies
Dupixent can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.
The recommended dose of Dupixent for adults and adolescents (12 years of age and older) is:
- an initial dose of 400 mg (two 200 mg injections) followed by 200 mg given every other week or
- an initial dose of 600 mg (two 300 mg injections) followed by 300 mg given every other week
- For patients with oral corticosteroids-dependent asthma, or with co-morbid moderate-to-severe atopic dermatitis for which Dupixent is indicated, start with an initial dose of 600 mg followed by 300 mg given every other week
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Is Dupixent safe to use while pregnant or breastfeeding?
Before using Dupixent, tell your healthcare provider about all your medical conditions, including if you:
What drugs interact with Dupixent?
Avoid use of live vaccines in patients treated with Dupixent.
Immune responses to vaccination were assessed in a study in which subjects with atopic dermatitis were treated once weekly for 16 weeks with 300 mg of dupilumab (twice the recommended dosing frequency). After 12 weeks of Dupixent administration, subjects were vaccinated with a Tdap vaccine (Adacel®) and a meningococcal polysaccharide vaccine (Menomune®). Antibody responses to tetanus toxoid and serogroup C meningococcal polysaccharide were assessed 4 weeks later. Antibody responses to both tetanus vaccine and meningococcal polysaccharide vaccine were similar in dupilumab-treated and placebo-treated subjects. Immune responses to the other active components of the Adacel and Menomune vaccines were not assessed.
Dupixent (dupilumab) is a treatment administered by subcutaneous injection for patients aged 12 years and older with moderate-to-severe atopic dermatitis (eczema) whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Dupixent can be used with or without topical corticosteroids.
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Related Disease Conditions
Eczema is a general term for many types dermatitis (skin inflammation). Atopic dermatitis is the most common of the many types of eczema. Other types of eczema include: contact eczema, allergic contact eczema, seborrheic eczema, nummular eczema, stasis dermatitis, and dyshidrotic eczema.
Eczema refers to skin inflammation. There are many different types of eczema that produce symptoms and signs that range from oozing blisters to crusty plaques of skin. Treatment varies depending upon the type of eczema the person has.
Is Eczema Contagious?
Eczema is a skin condition characterized by inflamed, rough skin patches that occasionally produce fluid-filled bumps that may ooze. There is no cure for eczema, though eczema may be treated with moisturization, eczema cream, and topical steroids.
Ringworm vs. Eczema
While ringworm is a fungal infection, and eczema is a skin condition, both are characterized by itchiness. Eczema patches are leathery while ringworm involves ring formation on the skin. Over-the-counter antifungals treat ringworm. Topical creams and ointments treat eczema.
Atopic Dermatitis vs. Eczema
Atopic dermatitis and eczema both refer to skin conditions. Atopic dermatitis is a cause of eczema, which refers to skin conditions that cause inflammation and irritation. The terms are sometimes used interchangeably. Eczema is not a condition in itself, but a description for a group of skin diseases that cause skin inflammation and irritation.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.