Patient Comments: Drug-Induced Liver Disease - Describe Your Experience


The symptoms of drug-induced liver disease can vary greatly from patient to patient. What were your symptoms at the onset of your disease? Submit Your Comment

Comment from: ehvmensa, 55-64 Male (Patient) Published: March 17

I had been diagnosed with hepatitis as a teen in the 70s and received treatment for it at the time. Not knowing any dangers associated with drinking I drank all my life. Then with a sore shoulder I was prescribed Voltaren (diclofenac sodium) and took 1 dose. I became violently ill, taking on all the adverse reactions I found on it. It caused my kidney and liver to fail. My kidney came back but I am on the transplant list for my liver. Always read the possible reactions to a drug before taking it.

Comment from: TCB, 35-44 Male (Patient) Published: September 02

I was prescribed Diclofenac Sod 75mg and had side affect dark urine and I took about 10 pills. I went for something else now stressed about an elevated bilirubin and I also stop taking Simvastatin. I will change diet and exercise to lower cholesterol. I am still under going tests, but this is not worth the side affects.

Comment from: GIMS, 55-64 Female (Patient) Published: July 15

I started noticing sore nodules in the upper portion of the liver. My urine became dark, and I had decreased urine output. I had been having fatigue for a long time that was diagnosed as anxiety and depression. I am very sensitive to drugs and usually have at least 50% of the side effects of any drug. I am so sad because nobody wanted to listen to my sensitivity to drugs. I refused to take some drugs because I would rather die than live with the side effects. I have ended up with acute liver disease because of some of the drugs I am on. The doctor instantly took me off HCTZ, and I am still worried about Norvasc and Benicar.

Comment from: Leo, 45-54 Male (Patient) Published: June 29

I am 52 with Hepatitis C and my next check up for that is a couple months away. Last month I had a hip resurface and have been on oxycodone. Now, I am not taking oxycodone because of the way it makes me feel and my pain is going away, except I need something to get me thru a nights sleep. My pain level is a lot better. My question is, what pain med over the counter or prescription is best for someone with Hepatitis C.

Comment from: Have FAITH, 35-44 Female (Patient) Published: June 29

I had a few glasses of wine one night, a few days later I became ill, feeling as though I had a flu but with stomach pains. I went to the doctor and she prescribed erythromycin (broad spectrum antibiotic) that night I collapsed on the floor in sever pain. I was taken to the ER where I was diagnosed with stomach pain and given (donnatal). When I returned home my sister (25miles away) called. The ER doctor had contacted my emergency contact as I was on the way home (in even more pain) he had over looked my labs, my alt and slt were elevated (in the thousands) and my pancreas was inflamed, he needed me to come back to the ER immediately. I did and went thru a series of tests and diagnosis on to finally discover that I had autoimmune hepatitis type I (a liver disease where your body attacks your liver) my symptoms were severe pain in my upper right rib cage, extreme fatigue, pale stool, itching, as best I can remember. I was also diagnosed with Hepatitis C and Sjroens syndrome therefore I couldn't be treated for the Hepatitis C. It would make the autoimmune hepatitis worse, so I was put on prednisone and something else but anyway I stopped taking all of it, started eating better and hydrating myself, got pregnant and my levels dropped back to normal. I now have two girls 5 and 2 and so far I feel really good. Let me make it clear that autoimmune hepatitis has a 10 year life expectancy and let me also make it clear that I would not be here today without the power of prayer and that's why I stopped the medications. It was a walk of faith.

Comment from: Trisha, 55-64 Female (Patient) Published: August 16

I am a 62 year old female diagnosed in May 2013 with primary liver cancer (bile duct cancer) cholangiocarcinoma Stage IV, spread to the lymph nodes. Inoperable. I have been a Zoloft (sertraline) user for approximately 15 years and have also taken Imimpramine (tofranil) for 25 years. Prior to May 2013 I thought I was quite healthy. As you can imagine, I am shocked and saddened by my recent diagnosis.

Comment from: Vi l, 75 or over Female (Patient) Published: July 19

I have Myasyemia Gravis which causes double vision. My doctor gave me a prescription for Azathioprine 50 mg.-once a day. This caused tiredness, loss of appetite, and nausea. Through blood tests it was noted that my liver had been damaged. Did the azathioprine do this. I went off it immediately and will have another blood test shortly to see if the results have improved.

Comment from: zeenna2002, 55-64 Male (Patient) Published: April 23

My platelets are high and I am taking hydroxyurea for two months. I developed drug-induced hepatitis and jaundice.

Comment from: Wooter, 45-54 Published: September 02

I have all the symptoms of liver disease. Swollen belly, tired, lower back pain, shortness of breath, nausea, lack of appetite. I recently started getting weird spots/red rashy things on my lower body, mainly around my upper thighs and stomach, high blood pressure, irregular heartbeat and more.

Published: June 29

I am a 19 year old female. One day I just started feeling really queasy all the time and not really having much of an appetite, this went on for days and I started getting worried I was pregnant, then I started noticing my urine was a really dark brown, I started getting to the point where I couldn't keep anything down I then immediately drove myself to the ER. When the ER doctor saw me she then noticed the whites of my eyes were yellow and right there she said hepatitis. After hours of tests and being admitted I was then released the next night, still feeling the same as when I came in they said it was viral it will take awhile to go away. The next day I still felt horrible and couldn't hold anything down. I called my doctor and he said to go to Dallas so I rushed to Dallas where they had a good liver team and after more and more tests and after being there 3 days I had to get a liver biopsy where I was then diagnosed with autoimmune hepatitis. When I was in high school I was on multiple tetracycline's for my acne and my doctors realized this is what triggered my liver to do this and now I will be on prednisone and azathioprine for 22 months. So watch out to anybody taking tetracyclines because this could happen.

Comment from: foxisenior2, 45-54 Male (Caregiver) Published: March 05

On Oct. 9, 2008, my 54-year-old son went to the emergency room with severe pain. At first, they thought it was gall stones. Then, after blood work, they discovered he had a leakage in his liver. He died on Dec. 4. He drank a couple of glasses of wine a day and took no drugs. He had ulcers in his bowel and esophagus at age 16 and was treated successfully with Prednisone and never had any more problems until the above. Before he died, he had bad jaundice and terrible itching and some bleeding.

Comment from: 55-64 Female (Patient) Published: September 17

3 weeks ago I collapsed at work, was taken to ER, collapsed again, and diagnosed with seizures. The neurologist put me on Dilantin, and I spent a dreadful week of confusion, weakness, fatigue, loss of appetite, etc. After 1 week of medication I developed a fever and a total body rash and was again admitted to hospital and taken off Dilantin. Now my WBC is 2.5, and all my liver enzymes are elevated. My doctor says I can't return to work until they return to normal, and then she will decide whether to put me on another anticonvulsant. I had a very extended bout of Hepatitis A 30 years ago. Could this be contributing to my reaction to this medication?

Comment from: Cat Eyes, 35-44 Female (Patient) Published: September 17

I was diagnosed with having upper respiratory infection. I was given Puromycin as an antibiotic as I am allergic to penicillin. During and after the course of antibiotics I became more ill, the respiratory infection would not clear and I puked everything I ate. I became weak and fragile, unable to walk in a matter of 2 days. I looked in the mirror realized my eyes were yellowing. I was raced to the emergency room. After blood and urine tests, I was diagnosed as having DRUG INDUCED JAUNDICE. This is the second time it has happened to me. After numerous and expensive blood tests four years ago (the doctors were unaware that it was drug induced Jaundice. It was only discovered now. I do not blame my doctor for what had happened to me, but surely they should be educated on the side effects of various drugs.

Published: June 25

I did not realize that taking Tylenol could cause Fatty Liver. I have taken Tylenol all of my adult life. I too, take Darvocet as well. My usual dose can amount to a Darvocet and a Tylenol maybe twice a day. Then between that I might take two Tylenol tablets. So in essence I take maybe up to six daily (Tylenol). I take this for pain of headache, backache, arthritis. I am 63 years of age.

Comment from: 19-24 Female (Patient) Published: August 21

Chronic cholestasis with elevated ALP, GGT, ALT and low albumin. Negative for viral hepatitis, autoimmunize hepatitis, Wilson's disease, etc. Have been on Dilantin for 2 years. Liver biopsy showed lobular inflammation. Will be seeing a specialist for further work up in September.

Comment from: jd, 7-12 Female (Caregiver) Published: August 17

My child is newly taking Sustiva and has developed white/yellow poop, is itchy, has flu like symptoms, and some sores in her throat. Are these all separate things. She has had some extreme fatigue and has been really having a hard time concentrating which we attributed to a appetite stimulating medication she is on.

Comment from: patches, 13-18 (Caregiver) Published: August 17

My son is a 17 year old autistic. He has been prescribed Seroquel, Lamictal, Zyprexa, and Depakote. You name it they have given it to him since he was 10 years old. Now they say his liver is showing damage. It stores sugar like that of a heavy drinker. I'm scared for him because of all the meds they still prescribe.

Comment from: heinz57, 55-64 Female (Patient) Published: August 17

I have some fatty liver and some scar tissue according to scat scan done last spring. All of my liver enzymes are slightly elevated. I had my gallbladder removed years ago and my enzymes have been edging at little higher every year. My doctors say this could be a natural reaction to that surgery, but deep inside of me, I don't think so. I am recovering from a complete hysterectomy at the moment and have been having a burning sensation in the area of my liver. Every time my body has to go through a recovery of some sort, I have liver trouble. Nausea is one of my symptoms as is a large jelly belly around the waist. I had some adrenal gland failure around that was brought on by a nasal spray for my sinuses. If any one has any suggestions, I would appreciate the input.

Comment from: 35-44 Male (Patient) Published: July 20

I contracted malaria whilst living in Malawi. The type of malaria was plasmodium falciparum, common in that region. I was treated with Fansidar, and as symptoms became worse, I received Augmentin intravenously. The symptoms were acute abdominal pains, fatigue, complete loss of appetite, nausea, and later jaundice. A few days later I was admitted to hospital with acute drug induced hepatitis. Although inconclusive, we now know that Augmentin is highly liver toxic, and likely played a crucial role in my illness.

Comment from: Kathy, 55-64 Female (Patient) Published: July 15

I am a 58 year old white women who has psoriasis in my hands as well as arthritis in hands and through out my body. My rheumatologist has me on methotrezate. Which really does help. Up under my rib cage I have distention as well as pain. Even lying on my side hurts. I have a full set of lab work to be done this week. Hopefully this will give me some indication of what is going on, If you have and comments I would appreciate it.

Comment from: Hoping, 35-44 Male (Patient) Published: July 15

Post MVA 16 years ago. On long term use of Tramadol and Norco (10/325). I increased dosage for relief (not abuse) however experienced liver failure symptoms over the last 4 days, including fever, disorientation, significant upper right quadrant abdominal pain, and anorexia. I eliminated most Norco with hope of getting back to normal within a week or so.

Comment from: pamela, 55-64 Female (Patient) Published: June 29

It started with a bad eye infection that started a few years ago and seems to return every year after that. I was given a drug called ACYCLOVIR 800MG. It worked for the eye problem, but I started feeling fatigue and eventually bloated with an extended stomach. I just recently had block tests. My doctor informed me the tests are negative for diabetes, cancer, aids etc.; however, my liver enzyme is elevated and they don't know the cause. I have wondered if the ACYCLOVIR might have something to do with it. I also have arthritic knees and have been taking 2 Aleve daily to help with the pain.

Comment from: Shocked, 55-64 Female (Patient) Published: June 04

I was prescribed 500 mg per day of naproxen for serious back pain. When naproxen came on the market as an OTC, I continued to take 4-600 mg a day when back pain occurred. After 3-4 years of periodic heavy dosing, I had heart palpitations and was eventually led to a diagnosis of cirrhosis, with ALT 319 and AST 234. 3 weeks after stopping naproxen, enzymes dropped to 79 and 59. In those weeks waiting for the naproxen to clear, itching, poor clotting and bruising occurred, but stopped after the naproxen cleared. Platelets were somewhat low and PT/PTT somewhat prolonged. Other values were normal. I was also diagnosed with hepatitis C and treated successfully for it for 6 months as a last-ditch effort to reverse fibrosis. I will have another biopsy in 1 year to assess my progress with reversal.

Comment from: atoutalors, 75 or over Female (Caregiver) Published: April 07

My 90 year old aunt was given Pneumovax while in the hospital for r/o CVA. Her arm turned purple and she had a huge hard lump at the injection site. She was on blood thinners. She is now in liver failure.

Comment from: 109 UK, 55-64 Male (Caregiver) Published: March 31

My father has just been diagnosed with advanced cirrhosis due to the medication taken over the last 12 years (paracetamol and codeine). We have been informed that he doesn't have a hernia diagnosed by our GP 2 years ago. The symptoms he described was pain in his stomach. We have now been told this was a sign.

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