- What is dronabinol-oral, and how does it work (mechanism of action)?
- What are the side effects of dronabinol-oral?
- What is the dosage for dronabinol-oral?
- Which drugs or supplements interact with dronabinol-oral?
- Is dronabinol-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about dronabinol-oral?
What is dronabinol-oral, and how does it work (mechanism of action)?
Dronabinol (Marinol) is a man-made compound that contains cannabinoids found in the marijuana plant (Cannabis sativa L). Dronabinol contains tetrahydrocannabinol (THC) in standardized concentrations and does not contain other compounds found in street marijuana that is not approved by the FDA for medical use. Dronabinol activates cannabinoid receptors causing a wide range of effects in the brain, including short-term memory loss, euphoria, enhanced sensation, and increased appetite. It also prevents nausea and vomiting probably by inhibiting the vomiting center in the brain. Dronabinol was approved by the FDA in May 1985.
What brand names are available for dronabinol-oral?
Is dronabinol-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for dronabinol-oral?
What are the side effects of dronabinol-oral?
The most common side effects of dronabinol include
- rapid heartbeat,
- facial flushing,
- abdominal pain,
- paranoid reaction, and
- abnormal thinking.
Less common side effects include
- low blood pressure,
- eye problems,
- fecal incontinence,
- muscle pain,
- speech problems,
- ringing in the ears (tinnitus), and
Dronabinol is a controlled substance because it may be abused.
What is the dosage for dronabinol-oral?
For appetite stimulation in AIDS patients
- The general recommended starting dose is 2.5 mg by mouth twice daily, before lunch and dinner.
- Patients who are having difficulty tolerating this dosage may take 2.5 mg once a day in the evening or at bedtime.
- In patients who are tolerating dronabinol well, the dose may be slowly increased up to a maximum dose of 20 mg per day.
For nausea and vomiting
- 5 mg per meter-squared of body surface (5 mg/m2) should be administered 1-3 hours before chemotherapy followed by repeated administration every 2 to 4 hours after chemotherapy for a total of 4 to 6 doses per day.
- If needed, the dosage may be increased in 2.5 mg/m2 increments to a maximum of 15 mg/m2 per dose.
Which drugs or supplements interact with dronabinol-oral?
Although no drug-drug interactions were identified during clinical trials conducted by the manufacturer, dronabinol should be used cautiously with other medications that are known to interact with cannabinoids.
People taking dronabinol should not drink alcohol, smoke marijuana, take sedatives and hypnotics, or take other medicines that have an effect on the central nervous system. Examples of drugs to avoid include diazepam (Valium), chlordiazepoxide (Librium), alprazolam (Xanax), secobarbital (Seconal), pentobarbital (Nembutal), and phenobarbital.
Is dronabinol-oral safe to take if I'm pregnant or breastfeeding?
There are no adequate and well-controlled studies evaluating the use of dronabinol during pregnancy. Dronabinol should only be used during pregnancy if the potential benefit to the mother justifies the potential risk to the unborn baby. Dronabinol is classified as FDA pregnancy risk category C. (Animal studies have shown adverse effects on the fetus, but there are no adequate studies in humans.)
What else should I know about dronabinol-oral?
What preparations of dronabinol-oral are available?
Oral capsules: 2.5, 5, and 10 mg
How should I keep dronabinol-oral stored?
Dronabinol capsules should be stored in a cool location between 8 C and 15 C (46 F and 59 F ) or in the refrigerator. Capsules should not be frozen.
Latest Cancer News
Daily Health News
Dronabinol (Marinol, THC), a compound that is man-made, is a drug prescribed to prevent nausea and vomiting associated with cancer chemotherapy in patients who have not responded to standard drugs to manage nausea and vomiting. Dronabinol also is prescribed to improve the appetite in patients with AIDs who have problems maintaining weight. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to administering this medication.
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Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Nausea and Vomiting
Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia. Some causes of nausea and vomiting may be life-threatening, for example, heart attack, abdominal obstruction, and cancers. Treatment of nausea and vomiting depends upon the cause.
Medical Marijuana (Medical Cannabis)
Medical marijuana (medical cannabis) is a medicine that is plant based. There are two species of medical marijuana; 1) Cannabis sativa, and 2) Cannabis indica. Medical marijuana is used to treat pain, nausea, anxiety, MS, insomnia, seizures, and muscle spasms. Medical cannabis is legal in a variety of states in the US. A card or licence is required to purchase medical marijuana in states where it is legal; however, medical cannabis is against Federal law. Medical marijuana comes in a variety of products, for example, gummy bears and other candy, muffins, cookies, drinks, salves, ointments, creams, oils, and wax.
AIDS (Acquired Immunodeficiency Syndrome)
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
What Is the Function of Endocannabinoids?
The endocannabinoid system (ECS) is a complex nerve cell signaling system that modulates the central nervous system’s function and helps maintain homeostasis. Homeostasis is the state of equilibrium in the body in which all the organs function optimally, maintaining physiological, cognitive and emotional balance. The active chemicals in Cannabis sativa (marijuana) interact with the ECS, and it was the study of these phytocannabinoids that lead to the discovery of the human ECS.
Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). Still incurable, AIDS describes immune system collapse that opens the way for opportunistic infections and cancers to kill the patient. Early symptoms and signs of HIV infection include flu-like symptoms and fungal infections, but some people may not show any symptoms for years. Highly active antiretroviral therapy (ART) is the standard treatment for HIV infection. These combination drug regimens have made HIV much less deadly, but a cure or vaccine for the pandemic remains out of reach. HIV is usually transmitted through sexual contact or sharing IV drug needles, but can also infect someone through contact with infected blood. Sexual abstinence, safe sex practices, quitting IV drugs (or at least using clean needles), and proper safety equipment by clinicians and first responders can drastically reduce transmission rates for HIV/AIDS.
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