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What is Drax Exametazime, and how does it work?
Drax Exametazime (kit for the preparation of technetium Tc 99m exametazime for leukocyte labeling) for intravenous use is a radioactive diagnostic agent indicated for leukocyte (white blood cell) labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
What are the side effects of Drax Exametazime?
Common side effects of Drax Exametazime include:
What is the dosage for Drax Exametazime?
Recommended Dosage And Administration
For an adult patient the recommended intravenous injection dose range for technetium Tc 99m exametazime labeled leukocytes is 259 -925 Megabecquerels (MBq) [7-25 millicuries (mCi)].
Image Acquisition And Interpretation
- Instruct patients to empty their bladder prior to imaging.
- Obtain serial pelvic and abdominal images beginning at 0.5 â€“ 1 hour post-injection and continue up to 4 Â hours.
- Accumulation of radioactivity in bowel seen in early images [less than 4 hours] with increasing intensity and/or no evidence of changing location secondary to GI motility likely represents inflammatory bowel disease or infection. Radioactivity from hepatic excretion detected in the bowel 4 hours post-injection and changing in GI location on serial/subsequent images is indicative of normal GI transit.
Is Drax Exametazime safe to use while pregnant or breastfeeding?
- Limited available data with technetium Tc 99m exametazime use in pregnant women are insufficient to inform a drug associated risk for major birth defects and miscarriage.
- Technetium Tc 99m exametazime is transferred across the placenta.
- Animal reproduction studies with technetium Tc 99m exametazime have not been conducted.
- However, all radiopharmaceuticals have the potential to cause fetal harm depending on the fetal stage of development and the magnitude of the radiation dose.
- If considering technetium Tc 99m exametazime administration to a pregnant woman, inform the patient about the potential for adverse pregnancy outcomes based on the radiation dose from technetium Tc 99m exametazime and the gestational timing of exposure.
- There are limited data available in the scientific literature on the presence of technetium Tc 99m exametazime in human milk.
- There no data available on the effects of technetium Tc 99m exametazime on the breastfed infant or the effects on milk production.
- Exposure of technetium Tc 99m exametazine to a breast fed infant can be minimized by temporary discontinuation of breastfeeding.
- The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for technetium Tc 99m exametazime, any potential adverse effects on the breastfed child from technetium Tc 99m exametazime or from the underlying maternal condition.
Drax Exametazime (kit for the preparation of technetium Tc 99m exametazime for leukocyte labeling) for intravenous use is a radioactive diagnostic agent indicated for leukocyte (white blood cell) labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease. Common side effects of Drax Exametazime include temporary increase in blood pressure, rash, facial swelling, fever, hives, itching, fatigue, feeling unwell (malaise), headache, dizziness, numbness and tingling, flushing, nausea, or vomiting.
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Related Disease Conditions
What Causes Abdominal Pain?
Abdominal pain can have many causes that range from mild to severe. Some of these causes include bloating, gas, colitis, endometriosis, food poisoning, GERD, IBS (irritable bowel syndrome), ovarian cysts, abdominal adhesions, diverticulitis, Crohn's disease, ulcerative colitis, gallbladder disease, liver disease, and cancers. Signs and symptoms of the more serious causes include dehydration, bloody or black tarry stools, severe abdominal pain, pain with no urination or painful urination. Treatment for abdominal pain depends upon the cause.
Inflammatory Bowel Disease (Intestinal Problems of IBD)
The inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
Abdominal Adhesions (Scar Tissue)
Abdominal adhesions (scar tissue) bands of scar tissue that form between abdominal organs and tissues. Symptoms of abdominal adhesions are pelvic or abdominal pain. Abdominal adhesions on the intestines can cause bowel obstruction, which is a medical emergency. Treatment for abdominal adhesions is generally surgery to cut the adhesions away from the internal tissues and organs. There is no way to prevent abdominal adhesions.
Peritonitis is a bacterial infection inside of the abdomen. Some doctors choose to group the causes of peritonitis into five categories; 1) primary peritonitis, 2) secondary peritonitis, 3) tertiary peritonitis, 4) chemical (sterile) peritonitis, and 5) peritoneal abscess. Others do not categorize peritonitis, they use a term to describe the disease in front or behind the word peritonitis. Symptoms include diarrhea, abdominal pain, nausea, and vomiting. Treatment is generally with antibiotics.
Inflammatory Bowel Disease (IBD) Diet
Inflammatory bowel disease (IBD) is a name for a group of diseases in which there is inflammation of the digestive tract (gastrointestinal tract). Crohn's disease and ulcerative colitis (UC) are the most common types of inflammatory bowel disease. While there is no specific recommended diet for a person with IBD, doctors and specialists recommend a low-residue (low fiber) diet for people with inflammatory bowel disease. Nutritionists, registered dieticians, and other health-care professionals can recommend specific foods, create meal plans, and recommend vitamins and other nutritional supplements.Foods to avoid with IBDExamples of foods to avoid that may trigger symptoms include if you have IBD include products alcohol, diary products, fatty, fried, and spicy foods, beans, and creamy sauces. Foods to eat with IBD Examples of a low-residue (low-fiber) diet that may help relieve symptoms after a flares of the disease are plain cereals, canned fruit, rice, oatmeal, and bananas.
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