- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: doxylamine
Brand Names: Unisom
What is doxylamine, and what is it used for?
Doxylamine is an over-the-counter sedative medication used as a sleep aid by people suffering from insomnia. Doxylamine is a sedative/hypnotic and is also an antihistamine drug that is used to relieve symptoms of upper respiratory tract allergies such as allergic rhinitis, hay fever and common cold, and nausea and vomiting associated with pregnancy. Doxylamine is a first-generation antihistamine that can easily cross the blood-brain barrier and induce drowsiness, unlike the second-generation antihistamines.
Doxylamine blocks the activity of histamine, a natural compound in the body, by binding to H1 histamine receptors, the protein molecules on cell surfaces that respond to histamine. Doxylamine binds non-selectively to all H1 receptors, including in the central and peripheral nervous systems, uterus, gastrointestinal tract, large blood vessels, and bronchial muscles.
Doxylamine works in the following ways:
- Blocks H1 histamine receptors in the sleep center in the brain causing drowsiness
- Reduces nausea and vomiting by inhibiting histaminergic signaling from the chemoreceptor trigger zone to the vomiting center in the medulla region of the brain
- Inhibits histamine receptors in the bronchial muscles, relieving upper respiratory tract allergy symptoms
- Suppresses the function of labyrinth, the middle ear chamber that helps maintain balance and hence causes the side effects of loss of balance and vertigo
- Do not use in patients who are hypersensitive to doxylamine or any of its components
- Do not use to treat insomnia in children below 12 years of age; may cause paradoxical excitation in young children
- Do not use doxylamine for longer than two weeks; consult your physician
- May cause central nervous system depression (CNS) impairing physical and mental abilities required for activities such as driving and operating heavy machinery
- Use chlorpheniramine with caution if you have any of the following conditions:
- Avoid concurrent use with monoamine oxidase inhibitors (MOAIs)
- Avoid use with other central nervous system (CNS) depressants including alcohol; may potentiate CNS effects
What are the side effects of doxylamine?
Side effects of doxylamine may include:
- Rapid heartbeat (tachycardia)
- Upper abdominal pain (epigastric pain)
- Loss of appetite (anorexia)
- Dry mouth (xerostomia)
- Dryness of mucous membranes
- Painful urination (dysuria)
- Urinary retention
- Paradoxical central nervous system (CNS) stimulation
- Blurred vision
- Double vision (diplopia)
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of doxylamine?
- 25 mg
Adults and Children over 12 years old:
- 25 mg orally every evening as needed 30 minutes before bedtime
- Not recommended for use in children under 12 years old
Upper respiratory tract allergy
- 50 mg orally every 4-6 hours
- Avoid use in the elderly because of the high incidence of anticholinergic effects
- Clearance is reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity
- May exacerbate existing lower urinary conditions or benign prostatic hyperplasia
- Tolerance develops when used as hypnotic
What drugs interact with doxylamine?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Doxylamine has no known severe interactions with other drugs.
- Serious interactions of doxylamine include:
- Doxylamine has moderate interactions with at least 167 different drugs.
- Mild interactions of doxylamine include:
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
What else should I know about doxylamine?
- Take doxylamine exactly as per the instructions on the label; seek medical help immediately in case of overdose
- Do not use regularly for longer than 2 weeks
- Store doxylamine out of reach of children
- Doxylamine may affect mental alertness and physical ability; do not engage in activities such as driving or operating heavy machinery after taking doxylamine
- Do not drink alcohol or take alcohol-containing drugs while on doxylamine therapy
Doxylamine is an over-the-counter sedative medication used as an insomnia sleep aid and an antihistamine drug used for allergies, hay fever, the common cold, and pregnancy nausea and vomiting. Side effects may include rapid heartbeat (tachycardia), palpitations, upper abdominal pain (epigastric pain), diarrhea, constipation, loss of appetite (anorexia), dry mouth (xerostomia), dryness of mucous membranes, painful urination (dysuria), urinary retention, headache, disorientation, drowsiness, dizziness, vertigo, paradoxical central nervous system (CNS) stimulation, blurred vision, and double vision (diplopia). Doxylamine is safe to use when pregnant. Use with caution while breastfeeding.
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How Soon Can You Get Symptoms of Pregnancy?
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Why Can't I Sleep by Myself?
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How Do I Get Rid of My Fear of Sleeping?
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Do You Hallucinate During Sleep Paralysis?
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Why Do People Sleepwalk (Somnambulism)?
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Can Morning Sickness Make You Depressed?
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Does Tryptophan Actually Make You Sleepy?
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How Soon Can You Get Morning Sickness?
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How Can I Fall Asleep in 2 Minutes?
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Do You Sleep More Deeply When Pregnant?
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How Much Sleep Should a Pregnant Woman Get in Second Trimester Pregnancy?
On average, you will get seven and a half hours of sleep per night during the second trimester of pregnancy.
Sleep Related Breathing Disorders
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What Are the 5 Types of Sleep Disorders in Children?
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What Causes Insomnia?
Insomnia is defined as repeated difficulty with sleep initiation, maintenance, consolidation, or quality that occurs despite adequate time and opportunity for sleep and results in some form of daytime impairment. There are three types of insomnia.
Is It Good to Sleep With Music On?
You can take your mind off of your everyday thoughts and stresses by playing music. Music is a great option to help improve your sleep.
How Do You Fall Asleep as Soon as You Hit the Bed?
Insomnia or lack of sleep is a frustrating experience. It makes you irritable and dull, as well as affects your physical and mental performance. Poor sleep can cause depression, body pain, heart disease, and diabetes.
Why Am I Having Trouble Sleeping at Night?
Having repeated difficulty with sleep initiation, maintenance or poor quality of sleep that occurs despite adequate time and opportunity for sleep, resulting in some form of daytime impairment is called insomnia.
Why Can't I Sleep Although I'm Tired?
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Is It True That the Older You Get, the Less Sleep You Need?
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When Should You Get Out of Bed If You Can't Sleep?
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How Many Hours Should Kids Sleep (By Age Group)?
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What Are the Four Warning Signs of Sleep Apnea?
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Some of the major reasons that may result in poor sleep include sleep disorders, mental health disorders, certain medications, and poor lifestyle choices.
Why Do Pregnant Women Get Morning Sickness?
Morning sickness, though exact cause is unknown, may be related to hormonal shifts and the increase in or presence of certain hormones.
What Foods Are Good for Morning Sickness?
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How Do You Fight Off Morning Sickness?
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Can You Die From Lack of Sleep?
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What Is the Best Natural Sleep Aid?
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How Can I Test Myself for Sleep Apnea?
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Can Working Out Mess Up Your Sleep?
Working out in the late evening does not interfere with sleep so long as you avoid vigorous exercising one hour before bedtime.
Can Diabetes Cause Lack of Sleep?
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What Are Good Sleep Habits?
Good sleep habits, also called sleep hygiene, include these fifteen tips that can help you gain a night of restful sleep.
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How Much Sleep Does an Adult Need?
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How Can I Help My Toddler With Sleep Problems?
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How Does Sleep Affect Your Heart?
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Treatment & Diagnosis
- Child Sleep Solutions
- Sleep Apnea
- Morning Sickness
- Sleep Paralysis
- Sleep: Getting a Good Night's Sleep -- Michael Breus, PhD
- Sleep: Hushabye with the Baby Whisperer -- Tracy Hogg
- Sleep Solutions: Michael Breus, PhD
- Sleep: Every New Parent's Dream
- Sleep and Health for Older Americans -- Sonia Ancoli-Israel, PhD
- Pregnancy Nutrition for All 4 Trimesters
- Sleep Disorders
- Sleep: Your Child's Sleep Habits and You
- Sleep Disorders in Adults
- Sleep Disorders with Kids
- Sleep FAQs
- Insomnia FAQs
- Progressive Muscle Relaxation
- Trouble Sleeping? Insomnia May Be Why
- 10 Tips to Avoid Insomnia and Get a Good Night's Sleep
- 8 Tips on How to Relax and Sleep When Stressed
- Sleep: Are You Sleep Deprived?
- Ambien: Sleeping Pill FAQs
- Snoring...A Productivity Problem!
- Sleep: At The Wheel With Sleep Apnea!
- What Is Twilight Sleep in Obstetrics?
- How Can You Sleep if You're Stressed?
- Anemia During Pregnancy
- Heartburn: Carbonated Soda & Sleeping Pills Increase Nighttime Heartburn
- Sleep Apnea Symptoms
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.