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- Doxycycline vs. Bactrim: What's the difference?
- What is Doxycycline? What is Bactrim?
- What are the side effects of doxycycline and Bactrim?
- What is the dosage of doxycycline vs. Bactrim?
- What drugs interact with doxycycline and Bactrim?
- Are doxycycline and Bactrim safe to use while pregnant or breastfeeding?
Doxycycline vs. Bactrim: What's the difference?
- Doxycycline and Bactrim (sulfamethoxazole and trimethoprim) are antibiotics used to treat many different types of bacterial infections.
- Brand names for doxycycline include Vibramycin, Oracea, Adoxa, Atridox, Acticlate, Acticlate Cap, Doryx, Doxteric, Doxy, and Monodox.
- Doxycycline and Bactrim are different types of antibiotics. Doxycycline is a tetracycline antibiotic and Bactrim contains an anti-bacterial sulfonamide (a "sulfa" drug) and an inhibitor of the production of tetrahydrofolic acid.
- Side effects of doxycycline and Bactrim that are similar include diarrhea or loose stools, nausea, and vomiting.
- Side effects of doxycycline that are different from Bactrim include abdominal pain, tooth discoloration if used in persons below 8 years of age, and exaggerated sunburn.
- Side effects of Bactrim that are different from doxycycline include dizziness, headache, lethargy, loss of appetite, rash, liver damage, low white blood cell count, low platelet count (thrombocytopenia), and anemia.
What is Doxycycline? What is Bactrim?
Doxycycline is an antibiotic in the tetracycline class used to treat many infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It is also used to treat non-gonococcal urethritis (due to Ureaplasma), typhus, anthrax, brucellosis, chancroid, cholera, Rocky Mountain spotted fever, syphilis, acne, and, periodontal disease.
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic that contains an anti-bacterial sulfonamide (a "sulfa" drug) and an inhibitor of the production of tetrahydrofolic acid. Bactrim is used to treat urinary tract infections, flares of chromic bronchitis due to bacteria, middle ear infections, to prevent infections due to pneumococcus in organ transplant recipients, to treat or prevent Pneumocystis carinii pneumonia, chancroid, and to prevent toxoplasma encephalitis in patients with AIDS.
What are the side effects of doxycycline and Bactrim?
Doxycycline is generally well-tolerated. The most common side effects are
Tetracyclines, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age. Exaggerated sunburn can occur with tetracyclines; therefore, sunlight should be minimized during treatment.
Common side effects of sulfamethoxazole/trimethoprim are:
Other side effects include:
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What is the dosage of doxycycline vs. Bactrim?
- The absorption of doxycycline is not markedly affected by food, and therefore, it can be taken with meals.
- For most infections, doxycycline is taken once or twice daily for 7 to 14 days.
- For adult infections, the usual dose of oral doxycycline is 200 mg on the first day of treatment (100 mg every 12 hours) followed by a dose of 100 to 200 mg/day as a single dose or divided and administered twice daily.
- The recommended adult dose for urinary tract infections is one double strength tablet (Bactrim DS, Septra DS) or two single strength tablets every 12 hours for 10 to 14 days.
- Flares of chronic bronchitis are treated with a similar regimen for 14 days.
- Sulfamethoxazole/trimethoprim should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. Persons with advanced kidney disease may require lower doses.
What drugs interact with doxycycline and Bactrim?
- It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine and prevent its absorption. Similarly, doxycycline should not be taken with minerals (such as calcium or iron) or with bismuth subsalicylate (Pepto Bismol).
- Doxycycline may enhance the activity of warfarin (Jantoven, Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline thus making it less effective.
- Doxycycline may interfere with the action of penicillins and should not be combined with penicillins. It may also reduce the effect of oral contraceptives. Combining tetracycline and methoxyflurane (Penthrane) may reduce kidney function.
Sulfamethoxazole/trimethoprim can enhance the blood-thinning effects of warfarin (Coumadin), possibly leading to bleeding. Sulfonamides such as sulfamethoxazole can increase the metabolism (break-down and elimination) of cyclosporine (causing loss of effectiveness of cyclosporine), and can add to the kidney damage caused by cyclosporine.
Blood levels of phenytoin (Dilantin) may be increased by treatment with sulfamethoxazole/trimethoprim. This may lead to side effects associated with phenytoin (Dilantin, Dilantin-125) such as dizziness, and reduced attention.
Sulfamethoxazole/trimethoprim also may increase blood levels of digoxin (Lanoxin) and possibly lead to serious toxic effects. Anemia, due to a reduction in folic acid, can occur in persons receiving sulfamethoxazole/trimethoprim in combination with:
- valproic acid (Depakote, Depakote ER, Depakene, Depacon, Stavzor),
- methotrexate (Rheumatrex, Trexall),
- triamterene, or
Increased blood levels of potassium may occur when sulfamethoxazole/trimethoprim is combined with ACE inhibitors.
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Are doxycycline and Bactrim safe to use while pregnant or breastfeeding?
Tetracycline antibiotics, such as doxycycline, can have toxic effects on development of bone in the fetus. Therefore, tetracyclines are not recommended during pregnancy unless there is no other appropriate antibiotic.
Doxycycline is secreted into breast milk but the extent of absorption by the breastfed infant is not known. Since tetracyclines can cause toxic effects on bone, the use of tetracyclines in nursing mothers is of concern. The physician must decide whether to recommend that a nursing mother discontinue nursing during treatment with tetracyclines or change to a different antibiotic.
Use of sulfonamides may cause bilirubin to be displaced from proteins in the infant's blood. Displacement of bilirubin can lead to jaundice and a dangerous condition called kernicterus in the infant. For this reason, sulfamethoxazole/trimethoprim should not be used near term (late in pregnancy) among women.
Sulfamethoxazole/trimethoprim should not be used by nursing mothers because sulfamethoxazole is excreted in milk and can cause kernicterus.
Doxycycline and Bactrim (sulfamethoxazole and trimethoprim) are antibiotics used to treat many different types of bacterial infections. Doxycycline and Bactrim are different types of antibiotics. Doxycycline is a tetracycline antibiotic and Bactrim contains an anti-bacterial sulfonamide (a "sulfa" drug) and an inhibitor of the production of tetrahydrofolic acid.
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Related Disease Conditions
Inner Ear Infection
An inner ear infection or otitis interna is caused by viruses or bacteria and can occur in both adults and children. An inner ear infection can cause symptoms and signs, for example, a severe ear, dizziness, vertigo, nausea and vomiting, and vertigo. An inner ear infection also may cause inflammation of the inner ear or labyrinthitis. Inner ear infections are not contagious; however, the bacteria and viruses that cause the infection can be transmitted to other people. Good hygiene practices will help decrease the chances of the infection spreading to others. Inner ear infection symptoms and signs like ear pain and nausea may be relieved with home remedies or over-the-counter (OTC) medication. Some inner ear infections will need to be treated and cured with antibiotics or prescription pain or antinausea medication.
Sinus Infection (Sinusitis)
Sinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
Staph (Staphylococcus) Infection
Staphylococcus or staph is a group of bacteria that can cause a multitude of diseases. Staph infections can cause illness directly by infection or indirectly by the toxins they produce. Symptoms and signs of a staph infection include redness, swelling, pain, and drainage of pus. Minor skin infections are treated with an antibiotic ointment, while more serious infections are treated with intravenous antibiotics.
H. pylori (Helicobacter Pylori) Infection
Helicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach, and also is the most common cause of ulcers worldwide. About 50% of people in the world carries or is infected with H. pylori. Common symptoms of H. pylori infection are occasional abdominal discomfort, bloating, belching or burping, and nausea and vomiting. H. pylori infection is difficult to eradicate, and treatment is with two or more antibiotics.
Middle Ear Infection (Otitis Media)
A middle ear infection (otitis media) can cause earache, temporary hearing loss, and pus drainage from the ear. It is most common in babies, toddlers, and young children. Learn about causes and treatment.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
Kidney Infection (Pyelonephritis)
Kidney infection (pyelonephritis) usually is caused by E. coli and other bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection can be cured with antibiotic treatment. Cranberry juice may prevent UTIs, but that hasn’t been proven in all research studies.
Is a Staph Infection Contagious?
A staph infection is caused by the bacteria Staphylococcus aureus. Staph can cause boils, food poisoning, cellulitis, toxic shock syndrome, MRSA, and various other illnesses and infections. Most staph infections are transmitted from person to person.
Is a Urinary Tract Infection (UTI) Contagious?
Bacteria such as E. coli or Pseudomonas can cause a urinary tract infection (UTI). The incubation period for a UTI ranges from three to eight days.
Is a Sinus Infection Contagious?
Sinus infection (sinusitis) is infection (viral, bacterial, or fungal) or inflammation of the sinuses. Symptoms of sinus infection are cough, bad breath, coughing up greenish-yellow sputum, sinus headache, and other symptoms of the common cold. Treatments of sinus infection are home remedies to soothe symptoms and antibiotics if the infection is bacterial or fungal.
Group A Streptococcal Infections
Second Source article from Government
Group A streptococcal infections are caused by group A Streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
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