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What is doxepin? What is doxepin used for?
Other examples of TCAs include amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and several others. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, an imbalance in levels of neurotransmitters in the brain may be the cause of the depression.
Neurotransmitters are chemicals that nerves use to communicate with each other. Neurotransmitters affected by doxepin include serotonin, norepinephrine, acetylcholine, and histamine. Doxepin may elevate mood by raising the levels of serotonin and norepinephrine.
It also blocks the activity of acetylcholine and histamine. The FDA approved doxepin in March 1974.
What brand names are available for doxepin?
Is doxepin available as a generic drug?
Do I need a prescription for doxepin?
What are the side effects of doxepin?
The most common side effect of doxepin is drowsiness. Drowsiness improves as therapy continues. Other side effects associated with doxepin include:
- blurred vision,
- urinary retention (difficulty urinating),
- dry mouth,
- weight gain or loss,
- low blood pressure when rising from a sitting position (orthostatic hypotension),
- rapid or irregular heart rates,
- seizures, and
Doxepin also can cause elevated pressure in the eyes of some patients withglaucoma. Doxepin may dilate pupils which may trigger an angle closure attack in a patient with angle closure glaucoma.
If antidepressants, including doxepin, are discontinued abruptly, symptoms may include:
Such symptoms of withdrawal may occur even when a few doses of antidepressant are missed. Therefore, it is recommended that the dose of antidepressant be reduced gradually when therapy is discontinued.
Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of any antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thinking or behavior, and unusual changes in behavior.
What is the dosage for doxepin?
The usual dose of doxepin for depression or anxiety is 25 to 300 mg daily administered at bedtime or in two or three divided doses. Doses greater than 300 mg daily are not more effective. Optimal improvement in depressive symptoms is seen after 2-3 weeks; anti-anxiety effects occur much sooner. Insomnia is treated with 3 to 6 mg daily taken 30 minutes before sleeping. Avoid taking doxepin with high fat meals because high fat meals increase the absorption of doxepin.
Which drugs or supplements interact with doxepin?
Tricyclic antidepressants , including doxepin, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants (for example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine [Parnate], selegiline [Eldepryl], and procarbazine [Matulane]) or other drugs that inhibit monoamine oxidase such as linezolid [Zyvox] and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Doxepin should not be administered for at least 14 days after stopping.
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Is doxepin safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of doxepin use in pregnant women.
What else should I know about doxepin?
What preparations of doxepin are available?
Capsules: 10, 25, 50, 75, 100, 150 mg; Liquid: 10 mg/ml
How should I keep doxepin stored?
Doxepin should be stored below 30 C (86 F) in a tight, light resistant container.
Doxepin doxepin (Sinequan and Adapin are discontinued brands in the US; Silenor) is an antidepressant that belongs to the drug class called tricyclic antidepressants. Doxepin is prescribed for depression, anxiety, bipolar disorder, or depression due to alcoholism or brain damage. Side effects and drug interactions should be reviewed prior to taking this medication.
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Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome or IBS is a GI disorder with symptoms of constipation, abdominal pain, bloating, and gas. IBS treatment includes medications, dietary changes, and lifestyle changes.
Urinary retention (inability to urinate) may be caused by nerve disease, spinal cord injury, prostate enlargement, infection, surgery, medication, bladder stone, constipation, cystocele, rectocele, or urethral stricture. Symptoms include discomfort and pain. Treatment depends upon the cause of urinary retention.
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
Alcoholism and Alcohol Abuse
Alcoholism is a disease that includes alcohol craving and continued drinking despite repeated alcohol-related problems, such as losing a job or getting into trouble with the law. It can cause myriad health problems, including cirrhosis of the liver, birth defects, heart disease, stroke, psychological problems, and dementia. Counseling and a few medications can be effective for alcoholism treatment.
Alcohol and Teens
Alcohol is the most frequently used drug by American teenagers. Teens that drink are more likely to drive under the influence, have unprotected sex, and use other drugs, like marijuana, cocaine, and heroin. Symptoms of alcohol abuse in teens include lying, breaking curfew, becoming verbally or physically abusive toward others, making excuses, smelling like alcohol, having mood swings, and stealing.
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known. Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping. Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
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Depression in Children
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Medications & Supplements
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- Drug Interactions
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- Hypnotics (for Sleep)
- amitriptyline (Elavil, Endep)
- nortriptyline (Pamelor)
- desipramine (Norpramin)
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Prevention & Wellness
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