- A Visual Guide to Migraine Headaches Slideshow
- Headache and Migraine Triggers Slideshow
- Take the Migraines Quiz
- What is doxepin, and how does it work (mechanism of action)?
- What brand names are available for doxepin?
- Is doxepin available as a generic drug?
- Do I need a prescription for doxepin?
- What are the side effects of doxepin?
- What is the dosage for doxepin?
- Which drugs or supplements interact with doxepin?
- Is doxepin safe to take if I'm pregnant or breastfeeding?
- What else should I know about doxepin?
What is doxepin, and how does it work (mechanism of action)?
Doxepin belongs to a class of drugs called tricyclic antidepressants (TCAs) that are used primarily to treat depression and anxiety. Other examples of TCAs include amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and several others. Depression is an all-pervasive sense of sadness and gloom. In some patients with depression, an imbalance in levels of neurotransmitters in the brain may be the cause of the depression. Neurotransmitters are chemicals that nerves use to communicate with each other. Neurotransmitters affected by doxepin include serotonin, norepinephrine, acetylcholine, and histamine. Doxepin may elevate mood by raising the levels of serotonin and norepinephrine. It also blocks the activity of acetylcholine and histamine. The FDA approved doxepin in March 1974.
What are the side effects of doxepin?
The most common side effect of doxepin is drowsiness. Drowsiness improves as therapy continues. Other side effects associated with doxepin include:
- blurred vision,
- urinary retention (difficulty urinating),
- dry mouth,
- weight gain or loss,
- low blood pressure when rising from a sitting position (orthostatic hypotension),
- rapid or irregular heart rates,
- seizures, and
Doxepin also can cause elevated pressure in the eyes of some patients withglaucoma. Doxepin may dilate pupils which may trigger an angle closure attack in a patient with angle closure glaucoma.
If antidepressants, including doxepin, are discontinued abruptly, symptoms may include:
Such symptoms of withdrawal may occur even when a few doses of antidepressant are missed. Therefore, it is recommended that the dose of antidepressant be reduced gradually when therapy is discontinued.
Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of any antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thinking or behavior, and unusual changes in behavior.
Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment
What is the dosage for doxepin?
The usual dose of doxepin for depression or anxiety is 25 to 300 mg daily administered at bedtime or in two or three divided doses. Doses greater than 300 mg daily are not more effective. Optimal improvement in depressive symptoms is seen after 2-3 weeks; anti-anxiety effects occur much sooner. Insomnia is treated with 3 to 6 mg daily taken 30 minutes before sleeping. Avoid taking doxepin with high fat meals because high fat meals increase the absorption of doxepin.
Which drugs or supplements interact with doxepin?
Tricyclic antidepressants , including doxepin, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants (for example, isocarboxazid [Marplan], phenelzine [Nardil], tranylcypromine [Parnate], selegiline [Eldepryl], and procarbazine [Matulane]) or other drugs that inhibit monoamine oxidase such as linezolid [Zyvox] and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Doxepin should not be administered for at least 14 days after stopping.
Is doxepin safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of doxepin use in pregnant women.
What else should I know about doxepin?
What preparations of doxepin are available?
Capsules: 10, 25, 50, 75, 100, 150 mg; Liquid: 10 mg/ml
How should I keep doxepin stored?
Doxepin should be stored below 30 C (86 F) in a tight, light resistant container.
Doxepin doxepin (Sinequan and Adapin are discontinued brands in the US; Silenor) is an antidepressant that belongs to the drug class called tricyclic antidepressants. Doxepin is prescribed for depression, anxiety, bipolar disorder, or depression due to alcoholism or brain damage. Side effects and drug interactions should be reviewed prior to taking this medication.
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Medications & Supplements
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- amitriptyline (Elavil, Endep)
- Drug Interactions
- Anxiolytics (for Anxiety) Drug Class Side Effects
- Hypnotics (for Sleep)
- nortriptyline, Pamelor, Aventyl - has been discontinued in the U.S.
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Prevention & Wellness
Migraines and Headaches Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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