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- What is doxazosin mesylate, and how does it work (mechanism of action)?
- What brand names are available for doxazosin mesylate?
- Is doxazosin mesylate available as a generic drug?
- Do I need a prescription for doxazosin mesylate?
- What are the side effects of doxazosin mesylate?
- What is the dosage for doxazosin mesylate?
- Which drugs or supplements interact with doxazosin mesylate?
- Is doxazosin mesylate safe to take if I'm pregnant or breastfeeding?
- What else should I know about doxazosin mesylate?
What is doxazosin mesylate, and how does it work (mechanism of action)?
Doxazosin is an oral drug used for treating high blood pressure and symptoms of benign prostatic hyperplasia (BPH, a noncancerous enlargement of the prostate gland). It belongs to a class of drugs called alpha-1 adrenergic blockers. Other drugs in this class include alfuzosin (Uroxatral), terazosin (Hytrin), tamsulosin (Flomax), silodosin (Rapaflo), and prazosin (Minipress). Doxazosin prevents norepinephrine that is released by nerves from binding to alpha-1 receptors on smooth muscle surrounding blood vessels and in the prostate and bladder. By blocking the effect of norepinephrine, doxazosin relaxes the smooth muscle. Relaxation of the smooth muscle surrounding blood vessels causes them to enlarge (dilate) and thereby reduces blood pressure. Relaxation of smooth muscle in the prostate and bladder improves the flow of urine and reduces the pain and discomfort characteristic of BPH. The FDA approved doxazosin in November 1990.
What are the side effects of doxazosin mesylate?
Common side effects of doxazosin include:
- shortness of breath,
- abdominal pain,
- edema (fluid accumulation) and
- low blood pressure.
Doxazosin causes significant reduction in blood pressure after administration of the first dose (first dose effect). This reduction in blood pressure may be associated with dizziness and fainting, especially when rising from a sitting position. To avoid this, patients should rise slowly from a sitting position, start treatment with the 1 mg dose, and then doses should be adjusted upwards slowly. Priapism (painful, prolonged penile erection) and a reduction in white blood cells have been associated with doxazosin.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
What is the dosage for doxazosin mesylate?
Which drugs or supplements interact with doxazosin mesylate?
Vardenafil (Levitra) or tadalafil (Cialis) and doxazosin have additive blood pressure lowering effects. Combining vardenafil or tadalafil (Cialis) with doxazosin may cause excessive blood pressure reduction.
Is doxazosin mesylate safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of doxazosin in pregnant women.
There are no adequate studies of doxazosin in nursing mothers.
What else should I know about doxazosin mesylate?
What preparations of doxazosin mesylate are available?
Tablets: 1, 2, 4, and 8 mg. Tablets (Extended Release): 4, 8 mg
How should I keep doxazosin mesylate stored?
Doxazosin should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Doxazosin mesylate (Cardura, Cardura XL) is a medication prescribed for the treatment of high blood pressure and the symptoms of benign prostatic hyperplasia (BPH, enlarged prostate gland). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
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High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Take the Enlarge Prostate Quiz and challenge your knowledge of prostate problems. Learn causes, symptoms, treatments, and...
Picture of Prostate Gland
A gland within the male reproductive system that is located just below the bladder. See a picture of Prostate Gland and learn...
High Blood Pressure (Hypertension): Symptoms, Causes, Treatments
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High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Benign prostatic hyperplasia (BPH or enlarged prostate) is very common in men over 50 years of age. Half of all men over the...
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Treatment & Diagnosis
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top doxazosin mesylate Related Articles
Alfuzosin (Uroxatral) is a drug that belongs to the alpha-blocker class of drugs, and is prescribed for the treatment of benign prostatic hypertrophy. The most common side are
- fainting, and
Drug interactions and dosage should be reviewed prior to taking this medication.
Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH or enlarged prostate) is very common in men over 50 years of age. Half of all men over the age of 50 develop symptoms of BPH, but few need medical treatment. This noncancerous enlargement of the prostate can impede urine flow, slow the flow of urine, create the urge to urinate frequently and cause other symptoms like complete blockage of urine and urinary tract infections. More serious symptoms are urinary tract infections (UTIs) and complete blockage of the urethra, which may be a medical emergency.
BPH is not cancer. Not all men with the condition need treatment, and usually is closely monitored if no symptoms are present. Treatment measures usually are reserved for men with significant symptoms, and can include medications, surgery, microwave therapy, and laser procedures. Men can prevent prostate problems by having regular medical checkups that include a prostate exam. Contact your doctor or other medical professional if you have these symptoms:
- Painful urination
- Blood in the urine
- Difficult urinating
- A frequent urge to urinate
- Dribbling of urine
Bladder SpasmsPeople who have bladder spasms, the sensation occurs suddenly and often severely. A spasm itself is the sudden, involuntary squeezing of a muscle. A bladder spasm, or "detrusor contraction," occurs when the bladder muscle squeezes suddenly without warning, causing an urgent need to release urine. The spasm can force urine from the bladder, causing leakage. When this happens, the condition is called urge incontinence or overactive bladder.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Take the BPH QuizTake the Enlarge Prostate Quiz and challenge your knowledge of prostate problems. Learn causes, symptoms, treatments, and diagnosis as well as little-known facts about the prostate, and what happens to men when the prostate is enlarged.
Febrile SeizuresFebrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include:
- losing consciousness,
- moving limbs on both sides of the body,
- lasts 1-2 minutes.
finasterideFinasteride (Proscar) is a drug prescribed for the treatment of prostate gland enlargement (benign prostatic hyperplasia or BPH). Side effects, drug interactions, pregnancy information, dosing, and patient information should be reviewed prior to taking any medication.
High Blood Pressure Hypertension
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms.
Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure.
The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater.
If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.
REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
High Blood PressureWhat causes high blood pressure (hypertension)? Know the warning signs and symptoms of high blood pressure. Read about high blood pressure medications, diet, and long term treatments.
Take the HBP QuizTake this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and heart attacks. How are dizziness, snoring, and gout related to HBP? Find the answer and learn how medical treatments and lifestyle adjustments fight this common problem.
High Blood Pressure TreatmentHigh blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.
prazosin-oralPrazosin hydrochloride (Minipress) is a drug prescribed to treat high blood pressure (hypertension), BPH (benign prostatic hyperplasia, hypertensive urgency, PTSD, and Raynaud's phenomenon. Side effects, drug interactions, warning and precautions, dosing, storage, breastfeeding, and pregnancy safety information should be reviewed prior to taking this drug.
Prostate Gland PictureA gland within the male reproductive system that is located just below the bladder. See a picture of Prostate Gland and learn more about the health topic.
tamsulosinFlomax (tamsulosin) is a drug prescribed for the treatment of benign prostatic hyperplasia (BPH, enlarged prostate). Side effects may include:
- Low blood pressure
- Increased triglycerides
- Abnormal ejaculation
- Upper respiratory tract infections
Drug interactions, warnings and precautions, and pregnancy and breastfeeding information should be reviewed prior to taking any medication.
Urinary IncontinenceThere are many types of urinary incontinence (UI), which is the accidental leakage of urine. These types include stress incontinence, urge incontinence, and overflow incontinence. Urinary incontinence in men may be caused by prostate or nerve problems. Treatment depends upon the type and severity of the UI and the patient's lifestyle.