GENERIC NAME: DOXAPRAM - INJECTION (DOX-uh-pram)
BRAND NAME(S): Dopram
USES: This medication is used to stimulate breathing (respiration). This medication can be used to treat breathing problems due to overdose of certain drugs (e.g., narcotic analgesics, barbiturates), lung disease (chronic obstructive pulmonary disease) and in the recovery period after anesthesia.
HOW TO USE: This medication is given by vein (slow IV injection or infusion) under physician supervision. Response will be monitored continuously during administration. Close observation and monitoring is necessary until the patient is fully alert for 1 hour. The dosage is based on your medical condition and response to the medication. The infusion should not be administered for longer than 2 hours or a maximum dose of 3 grams/24 hours. Learn all correct mixing, dilution and administration/usage instructions in the product package. Follow all proper safety precautions. Consult your pharmacist if you are unclear about any of the information. The liquid should be checked for particles or discoloration. If present, do not use the liquid. Make sure needles and medical supplies are stored safely and disposed of properly.
SIDE EFFECTS: Pain and redness at the injection site, feelings of warmth, flushing, sweating, headache, dizziness, nausea, diarrhea or enlarged pupils may occur. If these effects persist or worsen, notify the doctor promptly. Tell your doctor immediately if you have any of these unlikely but serious side effects: chest pain, rapid/irregular heartbeat, fever, mental/mood changes, increased muscle activity or spasms, seizures, urination problems, itching, trouble breathing (including very rapid or slow breathing). If you notice other side effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: Tell the doctor your medical history, especially of: allergies, lung problems (e.g., airway obstruction, asthma, COPD, pulmonary fibrosis), liver or kidney problems, heart conditions (e.g., arrhythmias, coronary artery disease), high blood pressure, brain swelling (cerebral edema), stroke, seizure disorders, head injury, thyroid conditions (e.g., hyperthyroid), pheochromocytoma, blood disorders (e.g., leukopenia, metabolic disorders). A preservative (benzyl alcohol) which may be found in this product or in the liquid used to mix this product (diluent) can infrequently cause serious problems (sometimes death), if given in large amounts (more than 100 mg/kg daily) to an infant during the first months of life (neonatal period). The risk is also greater with low birth weight infants. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat. Report these symptoms to the doctor immediately should they occur. If possible, a preservative-free product should be used when treating neonates. Tell your doctor if you are pregnant before using this medication. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription drugs you may use, especially of: certain cough- and-cold drugs with adrenaline-like medicine such as decongestants (e.g., ephedrine, pseudoephedrine), other sympathomimetic drugs (e.g., epinephrine, dopamine), MAO inhibitors (e.g., furazolidone, moclobemide, phenelzine, procarbazine, selegiline), drugs for anesthesia (e.g., halothane, cyclopropane and enflurane), muscle relaxants (e.g., succinylcholine, vecuronium). Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.
NOTES: Laboratory and/or medical tests will be performed to monitor your progress.
MISSED DOSE: If the dose is interrupted, contact the doctor or pharmacist immediately to establish new dosing.
STORAGE: Store the vials at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture. Do not freeze. After mixing and dilution in correct IV fluids (consult your pharmacist for details), this product is stable at room temperature for 48 hours.
MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Related Disease Conditions
The lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood. Eliminating carbon dioxide from the blood is important, because as it builds up in the blood, headaches, drowsiness, coma, and eventually death may occur. The air we breathe in (inhalation) is warmed, humidified, and cleaned by the nose and the lungs.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.