dopamine (hydrochloride; Intropin - Discontinued in the US)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

View the Heart Disease Slideshow

Is dopamine-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for dopamine-injection?

Yes

What are the uses for dopamine-injection?

  • Dopamine is prescribed to correct hemodynamic status in patients with shock syndrome due to
  • This means dopamine may be capable of improving urine flow, blood pressure, blood flow to vital organs, and improving heart function in patients with shock syndrome.

What are the side effects of dopamine-injection?

Common side effects of dopamine include

Serious side effects of dopamine include

  • abnormal heart rhythm,
  • increased or decreased blood pressure,
  • increased pressure in the eye, and
  • gangrene in the extremities.

Quick GuideHeart Disease: Symptoms, Signs, and Causes

Heart Disease: Symptoms, Signs, and Causes

What is the dosage for dopamine-injection?

FOR ADULTS

Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.

Safe and effective use of dopamine is not established in children.

Which drugs or supplements interact with dopamine-injection?

  • Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.
  • Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.
  • Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.

Is dopamine-injection safe to take if I'm pregnant or breastfeeding?

  • There are no adequate studies done on dopamine to determine its safe and effective use in pregnant women.
  • It is not known whether dopamine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

What else should I know about dopamine-injection?

What preparations of dopamine-injection are available?

  • Additive solutions for IV infusion: 40, 80, 160 mg/ml.
  • Infusion Solution: 80, 160, 320, mg/100 ml

How should I keep dopamine-injection stored?

Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).

REFERENCES:

FDA Prescribing Information.

Quick GuideHeart Disease: Symptoms, Signs, and Causes

Heart Disease: Symptoms, Signs, and Causes

Summary

Dopamine hydrochloride (Intropin - Discontinued in the US) is a prescription injection medication prescribed to correct hemodynamic status in people with shock syndrome due to

Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to using this medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

Subscribe to MedicineNet's Heart Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Reviewed on 9/21/2016
References
REFERENCES:

FDA Prescribing Information.

Health Solutions From Our Sponsors