Does Rheumatoid Arthritis Cause Granuloma?

Medically Reviewed on 10/28/2022
Rheumatoid Granulomas
Rheumatoid granulomas that don’t cause any limitation of function, pain, or discomfort may not require any specific treatment.

Yes, rheumatoid arthritis (RA) can cause granuloma in the body.

Although rheumatoid granulomas can occur at any site in the body, they most commonly affect the skin (which results in subcutaneous nodules).

  • They are typically seen at sites of repeated friction or pressure, such as the elbows, fingers, and forearms.
  • They may also occur on the back of the ankles, heels, the back side of the skull, and hips in bedridden people.

Subcutaneous nodules are seen in about one-fourth of patients with RA.

Rheumatoid granulomas can also occur in internal tissues and organs, such as the following: 

  • Lungs
  • White of the eyes (sclera)
  • Vocal cords
  • Liver
  • Kidneys
  • Inside the mouth
  • Thyroid gland
  • Pancreas

Why does rheumatoid arthritis cause granuloma?

A granuloma is a collection of immune cells formed in response to inflammation. Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. This means that the immune system in a person with RA attacks the body’s tissues. This immune attack triggers considerable inflammation, which results in the recruitment of inflammatory cells in the body. These inflammatory cells form clumps with areas of dead tissue (necrosis), which leads to granuloma formation.

What are the symptoms of rheumatoid granulomas?

Symptoms of rheumatoid granuloma may depend on its site. The granulomas under the skin are easier to identify than those affecting internal organs.

  • Subcutaneous nodules appear small (2 mm to 5 cm in size), round to oval skin-colored bumps under the skin (subcutaneous).
  • They are typically painless and movable although they may get fixed to the underlying structures in some cases.
  • They are generally not a cause for concern; however, they may interfere with function or become painful due to repeated trauma or compression of nerves in their vicinity. 
  • Repeated trauma may also make them prone to ulceration and consequent infection, which may spread through the blood to other sites as well.

Rheumatoid granulomas in internal organs may cause symptoms related to the affected organ.


The term arthritis refers to stiffness in the joints. See Answer

How do doctors diagnose rheumatoid granuloma?

A person can be diagnosed with rheumatoid granuloma based on the following:

  • Medical history
  • Physical examination to look for joint inflammation or deformity and subcutaneous nodules. Other relevant diagnostic approaches include examination of the joints, chest, and abdomen
  • Investigations such as:
    • Blood tests including tests for autoantibodies in the blood (such as rheumatoid factor and anti-cyclic citrullinated peptide antibody), inflammatory markers (such as erythrocyte sedimentation rate and C-reactive protein), liver involvement (liver function tests), and kidney involvement (kidney function tests)
    • Imaging studies such as X-ray, ultrasound, endoscopic ultrasound, CT scan, and MRI
    • Other tests such as ECG to look for heart involvement and pulmonary function tests to assess lung involvement
    • Biopsy to remove a small piece of tissue from the lesion and examine it under a microscope

How is a rheumatoid granuloma treated?

Rheumatoid granulomas may not require any specific treatment. For example, subcutaneous nodules that do not cause any limitation of function, pain, or discomfort may be left as such. 

Treatment options for rheumatoid arthritis (RA), such as corticosteroids, disease-modifying antirheumatic drugs, and biological agents, may help limit the disease and granuloma formation. If a certain drug used for RA treatment (such as methotrexate) causes nodule formation, the doctor may suggest an alternative.

Painful subcutaneous nodules may require local injections with steroids or numbing agents (local anesthetics). Some may need to be surgically removed. 

Visceral nodules, which affect the internal organs, may be surgically removed if they cause any problems or have a risk of complications. Surgical removal may also help diagnose the cause of granuloma. Lung (pulmonary) nodules are usually surgically removed as they carry a risk of lung complications such as scarring, pleural effusion, or small airway obstruction. Cardiac nodules may be surgically removed if they cause abnormal heart function or rhythm or blood vessel blockage (embolism).

Medically Reviewed on 10/28/2022
Image Source: iStock image,risk%20of%20multiple%20granulomatous%20dermatitides.