Does Glucosamine Chondroitin Really Work?

Glucosamine and chondroitin are cartilage components that the body naturally produces. By supplementing the cartilage tissue, discomfort and swelling in the joints that are most prone to be affected by osteoarthritis can be lessened. Also, this can prevent the breakdown of connective tissues.

Chondroitin is derived from the cartilage of cow tracheas, whereas glucosamine is derived from shellfish shells (crabs, lobsters and shrimps). Their chemical composition is similar to cartilage molecules, and their manufacturers claim that they help worn cartilage. However, medical experts and researchers are skeptical about their benefits.

Chondroitin and glucosamine are thought to be chondroprotective (which means they might stop the pain and the progression of arthritis). In addition to glucosamine, chondroitin helps pull water and nutrients into the cartilage, maintaining its elasticity.

• Glucosamine and chondroitin have been shown to inhibit cartilage breakdown, reducing joint discomfort and promoting healthy joints in studies.
• They also help maintain cartilage structure, since glucosamine and chondroitin contain anti-inflammatory qualities that can help minimize cartilage degeneration and pain in the joints.

To summarize, when these supplements are taken together, they do the following:

• Maintain and promote joint health
• Assist in the relief of mild to moderate joint pain
• Assist in the growth and production of healthy joint cartilage

The typical daily dose is 1,500 mg of glucosamine and 1,200 mg of chondroitin sulfate, either all at once or in divided doses. For heavier individuals, this can be increased to 2,000 mg of glucosamine and 1,600 mg of chondroitin.

Effectiveness of glucosamine and chondroitin

The effects of glucosamine and chondroitin may not be noticeable for at least six to eight weeks, and their benefits become apparent in about four to six months. If no benefit is seen after six months, the supplement should be discontinued.

The side effects of glucosamine and chondroitin include:

Common side effects

• Skin rashes
• Allergic reactions
• Hair loss
• Nausea
• Heartburn
• Abdominal bloating
• Diarrhea
• Constipation
• Indigestion
• Weight gain

Serious side effects (often rare)

• Bovine spongiform encephalopathy (mad cow disease is a progressive neurological disease) is a theoretical risk
• Increase in intraocular pressure (reversible condition)
• Worsening of preexisting diseases (diabetes, respiratory and liver diseases)
• Severe allergic reaction due to their shellfish content

Who should avoid taking glucosamine and chondroitin?

The following groups may want to avoid these supplements:

• People with uncontrolled diabetes
• Patients with respiratory and liver diseases
  • If there is a pre-existing condition (such as asthma or hemophilia) or if there is a family history of prostate cancer, doctors may not prescribe these supplements
• People with seafood and shellfish allergy
• Children and pregnant women
• People on blood thinners
• People suffering from increased eye pressure and glaucoma

Doctors may not support or refute the use of glucosamine and chondroitin sulfate until scientific, prospective, randomized studies are conducted to demonstrate and prove that these drugs are both safe and effective.