Dr. Jill Pamela Buyon , MD

Rheumatology

(212) 598-6355

Center For Musculoskeletal & Sports Medicine
333 E 38th St Fl 4
New York, NY 10016

Overview

Isolated congenital heart block (CHB), detected in utero in a previously normal heart, is strongly associated with autoantibodies that recognize the intracellular soluble ribonucleoproteins 48kD SSB/La, 52kD SSA/Ro, and 60kD SSA/Ro. Neonatal disease is presumed to be due to the transplacental passage of these IgG autoantibodies into the fetal circulation from the mother who may have systemic lupus erythematosus, Sjogren syndrome, or be entirely asymptomatic. However, the role of these antibodies in the direct pathogenesis of cardiac injury is unknown. After characterizing numerous affected neonates and their mothers with respect to health status and antibody profile, we have focused on explaining two major clinical observations: 1) permanent disease does not occur in other fetal organs and the maternal heart is unaffected despite exposure to the identical circulating antibodies; and 2) not all mothers with these antibodies have offspring with disease implying involvement of as yet unknown factors. In addition to these considerations is the overriding question of how intracellular antigens become accessible targets of maternal autoantibodies. We demonstrated that a major antigenic target characterizing the autoimmune response in mothers whose children have manifestations of neonatal lupus is the 52kD Ro protein (52a), which contains an N-terminal zinc finger domain and central leucine zipper. We recently identified an alternative 52mRNA derived from splicing exon 4 inclusive of the leucine zipper, which encodes a smaller protein, 52b, with a predicted molecular weight of 45kD which is immunoprecipitated by over 80% of sera from CHB mothers. Expression of 52b is greatest between 14 and 16 wks of gestation, a time of cardiac ontogeny when maternal antibodies gain access to the fetal circulation just prior to the clinical detection of CHB. Additionally, protein interactions with 52a and 52b are being sought using human adult and fetal (14-24 wk) heart libraries in a two-hybrid system. Human fetal cardiocytes are being cultured to address issues of antigen localization and accessibility to antibody under different conditions. To further the study of neonatal lupus and congenital heart block, we established a national Research Registry for Neonatal Lupus which currently includes 352 affected families.

Gender: N/A

Years in Practice: 42 Years

Languages Spoken: Spanish and Korean

Education & Training

Medical School: Albert Einstein Med Col

Graduation Date: in 1978

Specialties & Hospital Affiliations

Hospital Affiliations:

  • New York University Hospital For Joint Diseases

Specialties: Rheumatology

Health Insurance and Affiliations

  • Aetna Choice POS II
  • Aetna Choice POS Open Access
  • Aetna Elect Choice EPO
  • Aetna HMO
  • Aetna Managed Choice POS Open Access
  • Aetna NYC Community Plan
  • Aetna Signature Administrators PPO
  • Affinity Essential Qualified Health Plans
  • BCBS Blue Card PPO
  • BCBS MA Blue Care Elect PPO
  • BCBS MA Preferred Blue PPO
  • Empire HMO
  • Empire HMO Bronze Individual via Exchange
  • Empire PPO
  • Fidelis Care NY State of Health HBX
  • Healthfirst NY HMO ABCD
  • Healthfirst NY Silver Leaf
  • Highmark Community Blue PPO

Dr. Buyon's Office Information

Center For Musculoskeletal & Sports Medicine
333 E 38th St Fl 4
New York, NY 10016
(212) 598-6355

Fax: (646) 650-1723
Website: med.nyu.edu/orthosurgery
Accepting New Patients: Yes
Medicare Accepted: Yes
Medicaid Accepted: No

Office Hours:

Mon8:30 AM-5:00 PM
Tue8:30 AM-5:00 PM
Wed8:30 AM-5:00 PM
Thu8:30 AM-5:00 PM
Fri8:30 AM-5:00 PM
Sat-
Sun-

Doctor Buyon's Other Office Information

NYU Center For Musculoskeletal Care
333 E 38th St Fl 4
New York, NY 10016
(212) 598-6355

Fax:(646) 675-4960
Website:nyulangone.org
Accepting New Patients: Yes
Medicare Accepted:Yes
Medicaid Accepted:No

Office Hours:

Mon8:30 AM-5:00 PM
Tue8:30 AM-5:00 PM
Wed8:30 AM-5:00 PM
Thu8:30 AM-5:00 PM
Fri8:30 AM-5:00 PM
Sat-
Sun-

Yusuf Yazici Md
246 E 20th St
New York, NY 10003
(718) 834-0070

Fax:
Website:Not available
Accepting New Patients: No
Medicare Accepted:No
Medicaid Accepted:No

Office Hours:

N/A