John Michael Pagel , MD

Internal Medicine , Hematology/Oncology and Medical Oncology

(206) 288-7611

University Of Washington Physicians
825 Eastlake Ave E
Seattle, WA 98109

Overview

It was a tie between wanting to be a professional baseball player and being a physician for John Pagel growing up. Medicine won. Naturally drawn to science, he first pursued a PhD in molecular genetics. That was not enough, however. "I realized early in my PhD training that, in order to truly make a difference in patients lives, I needed to translate lab discoveries to real treatment options for patients and that meant going to medical school, too," says Pagel. Today, Dr. Pagel divides his time between the lab and caring for patients with leukemia or lymphoma, and those undergoing transplantation. He is currently an Associate Professor of Medicine at University of Washington, Division of Oncology and an Associate Member at the Fred Hutchinson Cancer Research Center. "The opportunity to make significant advances toward curing people of their disease is what led me to blood cancers," Pagel says. "Theres no more exciting time than now to be in this field. We are gaining the research and clinical insight needed to more effectively manage leukemia and lymphoma with less toxicity. I try to share the sense of hope with all of my patients." In his lab, Dr. Pagel collaborates with researchers at Fred Hutchinson Cancer Research Center to develop novel treatment approaches for blood cancers. Building on the work of Drs. Fred Appelbaum, Oliver Press, and others, he is exploring new ways to administer targeted immunotherapies to patients with leukemia and lymphoma. In particular Dr. Pagel has a research interest in radiolabeled antibody therapy, which works by delivering small doses of radiation directly to the cancer cells. "One challenge with the current way this therapy is administered is that after its injected into a patient, the radioactive antibody circulates in the body before actually binding to the cancer cells, which may expose non-cancerous tissue and organs to unnecessary therapy," Pagel says. "If we can identify ways to make the approach more targeted, we have the chance of minimizing toxicity, while decreasing the likelihood of recurrence." Thats just what he and his team are researching now in the lab and in clinical trials with patients. The method, referred to as "pretargeting," involves first injecting an antibody without the radioactive label which finds its way to the cancer cells. Then, the radioactive molecules are injected and bind specifically to the antibody. "Further research is clearly needed in this area, but early studies suggest this may allow us to give patients higher doses of radiation, which gives us a much better hope to put their disease in remission without increasing side-effects," says Pagel. Dr. Pagels commitment to patients extends beyond the Seattle area. He frequently presents to patient audiences internationally and around the country and through teleconferences and webcasts aimed at providing patients with up-to-date disease and treatment information. When Dr. Pagel is not caring for patients or in the lab, he can be found skiing down double diamonds and unchartered terrain, enjoying sports, or coaching very talented youth baseball teams.

Gender: Male

Years in Practice: 24 Years

Languages Spoken: Spanish and Chinese

Education & Training

Medical School: Boston University School Of Medicine

Graduation Date: in 1996

Specialties & Hospital Affiliations

Hospital Affiliations:

  • Swedish Medical Center Issaquah
  • Seattle Children's Hospital
  • University Of Washington Medical Center
  • Swedish Medical Center Ballard

Specialties: Internal Medicine , Hematology/Oncology and Medical Oncology

Health Insurance and Affiliations

  • Aetna Choice POS II
  • Aetna Managed Choice POS Open Access
  • Aetna Signature Administrators PPO
  • Aetna Whole Health Pacific Medical Centers WA
  • Aetna Whole Health Providence Swedish WA
  • Ambetter - CCCWA Exchange MRF
  • BCBS Blue Card PPO
  • CIGNA HMO
  • CIGNA Open Access Plus
  • CIGNA PPO
  • First Health PPO
  • Humana Choice POS
  • Moda Health First Choice Network
  • Premera Heritage and Heritage Plus 1
  • Premera LifeWise Connect
  • Regence WA Preferred Provider Network
  • UHC Choice Plus POS
  • UHC Navigate HMO
  • UHC Navigate POS
  • UHC Options PPO

Pagel's Office Information

University Of Washington Physicians
825 Eastlake Ave E
Seattle, WA 98109
(206) 288-7611

Fax: (206) 628-8102
Website: www.seattlecca.org
Accepting New Patients: Yes
Medicare Accepted: Yes
Medicaid Accepted: Yes

Office Hours:

Mon8:00 AM-5:00 PM
Tue8:00 AM-5:00 PM
Wed8:00 AM-5:00 PM
Thu8:00 AM-5:00 PM
Fri8:00 AM-5:00 PM
Sat-
Sun-

Doctor Pagel's Other Office Information

Swedish Medical Group
1221 Madison St Ste 1000 Fl 10
Seattle, WA 98104
(206) 991-2040

Fax:(206) 621-5165
Website:swedish.org
Accepting New Patients: Yes
Medicare Accepted:Yes
Medicaid Accepted:No

Office Hours:

Mon9:00 AM-5:00 PM
Tue9:00 AM-5:00 PM
Wed9:00 AM-5:00 PM
Thu9:00 AM-5:00 PM
Fri9:00 AM-5:00 PM
Sat-
Sun-

Swedish Medical Group
1221 Madison St
Seattle, WA 98104
(206) 215-2658

Fax:(206) 638-6239
Website:swedish.org
Accepting New Patients: Yes
Medicare Accepted:Yes
Medicaid Accepted:No

Office Hours:

Mon8:30 AM-5:00 PM
Tue8:30 AM-5:00 PM
Wed8:30 AM-5:00 PM
Thu8:30 AM-5:00 PM
Fri8:30 AM-5:00 PM
Sat-
Sun-

Fax:
Website:Not available
Accepting New Patients: No
Medicare Accepted:No
Medicaid Accepted:No

Office Hours:

N/A

Swedish Cancer Institute
1221 Madison St Fl 3
Seattle, WA 98104
(206) 386-2525

Fax:(206) 638-6239
Website:www.swedish.org
Accepting New Patients: Yes
Medicare Accepted:Yes
Medicaid Accepted:No

Office Hours:

Mon-
Tue-
Wed-
Thu-
Fri-
Sat-
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Swedish Center For Blood Disorders And Stem Cell Transplantation
1221 MADISON ST
SEATTLE, WA 98104
(206) 991-2040

Fax:
Website:www.swedish.org
Accepting New Patients: Yes
Medicare Accepted:Yes
Medicaid Accepted:No

Office Hours:

Mon-
Tue-
Wed-
Thu-
Fri-
Sat-
Sun-

View All Internal Medicine , Hematology/Oncology and Medical Oncology Specialist Doctors in Bellevue, WA