- Take the Tummy Trouble Quiz
- Boost Digestive Health
- Digestive Distress Slideshow: Problem Foods to Avoid
- What is diphenoxylate and atropine, and how does it work (mechanism of action)?
- What brand names are available for diphenoxylate and atropine?
- Is diphenoxylate and atropine available as a generic drug?
- Do I need a prescription for diphenoxylate and atropine?
- What are the side effects of diphenoxylate and atropine?
- What is the dosage for diphenoxylate and atropine?
- Which drugs or supplements interact with diphenoxylate and atropine?
- Is diphenoxylate and atropine safe to take if I'm pregnant or breastfeeding?
- What else should I know about diphenoxylate and atropine?
What is diphenoxylate and atropine, and how does it work (mechanism of action)?
Lomotil is a combination of two drugs, diphenoxylate and atropine. It is used to treat acute diarrhea (diarrhea of limited duration). Diphenoxylate is a man-made narcotic chemically related to meperidine (Demerol). Like other narcotics, diphenoxylate reduces diarrhea by interfering with the propulsion of intestinal contents through the intestines. Although diphenoxylate is chemically related to narcotics, it does not have pain- relieving (analgesic) actions like most other narcotics. In higher doses, however, like other narcotics, diphenoxylate can cause euphoria (elevation of mood) and physical dependence. In order to prevent abuse of diphenoxylate for its mood-elevating effects, atropine is combined with diphenoxylate in small quantities. As a result, if Lomotil is taken in greater than recommended doses unpleasant side effects from too much atropine will occur. Lomotil was approved by the FDA in 1960.
What are the side effects of diphenoxylate and atropine?
The most common side effects reported in persons taking diphenoxylate include:
Other important side effects include:
- numbness of extremities,
- loss of
- appetite, and
- abdominal pain.
Although the dose of atropine in Lomotil is too low to cause side effects when taken in the recommended doses, side effects of atropine (including dryness of the skin and mucous membranes, increased heart rate, urinary retention, and increased body temperature) have been reported, particularly in children under two years of age and children with Down syndrome. Pancreatitis and toxic megacolon also have been reported.
Quick GuideDigestive Disorders: Common Misconceptions
What is the dosage for diphenoxylate and atropine?
In adults, the usual dose is 5 mg (2 tablets) of diphenoxylate three to four times per day initially. Thereafter, the dose may be decreased to 2.5 mg (1 tablet) two to three times a day. The dose for children (2 to 12 years old) is 0.3 to 0.4 mg/kg/day in four divided doses. If diarrhea is not better within 48 hours, diphenoxylate is not likely to be effective with more prolonged treatment.
Which drugs or supplements interact with diphenoxylate and atropine?
The combination of diphenoxylate and monoamine oxidase inhibitors (MAO's), for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) can cause severe high blood pressure with the possibility of a cerebrovascular accident (stroke).
Drugs which increase the propulsion of intestinal contents theoretically can reduce the effectiveness of diphenoxylate. Such drugs include bethanechol (Urecholine), cisapride (Propulsid), metoclopramide (Reglan), and erythromycin.
Drugs which decrease the propulsion of intestinal contents may exaggerate the effects of diphenoxylate and cause constipation. Such drugs include hyoscyamine (Levsin; Cystospaz), antihistamines such as hydroxyzine (Vistaril, Atarax) and diphenhydramine (Benadryl), opiate agonists such as oxycodone (Percocet) and hydrocodone (Vicodin, Norco, etc.), some phenothiazine antipsychotics such as chlorpromazine (Thorazine), thioridazine (Mellaril) and triflupromazine (Stelazine), and some tricyclic antidepressants such as amitriptyline (Elavil, Endep), amoxapine (Asendin), clomipramine (Anafranil), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil).
Taking diphenoxylate with alcohol or other chemicals or medications that can depress the central nervous system may cause excessive sedation. Such drugs include barbiturates, benzodiazepines, for example, lorazepam (Ativan), diazepam (Valium), temazepam (Restoril), oxazepam (Serax), or clonazepam (Klonopin), zolpidem (Ambien), narcotics, and tricyclic antidepressants (listed above).
Is diphenoxylate and atropine safe to take if I'm pregnant or breastfeeding?
Adequate studies of diphenoxylate in pregnant women have not been done, so diphenoxylate should be used during pregnancy only when clearly needed.
Diphenoxylic acid, a metabolite of diphenoxylate (that is, diphenoxylate that has been changed chemically by the body) is excreted into breast milk, as is atropine. Although there have not been problems reported in the infants of women who breastfeed, the benefits to the mother should be weighed against the potential risks to the nursing infant.
What else should I know about diphenoxylate and atropine?
What preparations of diphenoxylate and atropine are available?
Tablets (2.5 mg diphenoxylate and 0.025mg atropine); liquid (2.5mg diphenoxylate and 0.025mg atropine per teaspoonsful).
How should I keep diphenoxylate and atropine stored?
Lomotil should be stored at room temperature, 15-30 C (59- 86 F).
Diphenoxylate and atropine (Lomotil) is a drug prescribed for the treatment of acute diarrhea. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Diarrhea (Causes, Medicine, Remedies, Treatment)
Diarrhea is a change is the frequency and looseness of bowel movements. Symptoms associated with diarrhea are cramping, abdominal...
Irritable Bowel Syndrome (IBS) Symptoms, Diet, Treatment, and Test
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms of: Abdominal...
Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)
Microscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis...
Bowel or fecal incontinence refers to the loss of voluntary control of stool, or bowel movements. The condition can include...
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas...
Travelers' diarrhea is generally contracted by eating contaminated food or drinking contaminated water. Food is the primary...
Travelers should prepare for their trip by visiting their physician to get the proper vaccinations and obtain the necessary...
Treatment & Diagnosis
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
- Drugs: Buying Prescription Drugs Online Safely
- Medication Disposal - What to Do with Old or Unusable Medication
- Dangers of Mixing Medications
- Drugs: The Most Common Medication Errors
Medications & Supplements
Prevention & Wellness
Daily Health News
Digestive Disorders Resources
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top diphenoxylate and atropine Related Articles
DiarrheaDiarrhea is a change is the frequency and looseness of bowel movements. Symptoms associated with diarrhea are cramping, abdominal pain, and the sensation of rectal urgency. Causes of diarrhea include viral, bacterial, or parasite infection, gastroenteritis, food poisoning, and drugs. Absorbents and anti-motility medications are used to treat diarrhea.
Worst Foods for DigestionDiscover which foods to avoid in order to prevent diarrhea and digestive problems. Find out which foods can trigger diarrhea and other digestive problems such as gas, bloating, indigestion, heartburn and more.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Fecal IncontinenceBowel or fecal incontinence refers to the loss of voluntary control of stool, or bowel movements. The condition can include partial incontinence, in which a person loses only a small amount of liquid waste, to complete incontinence, in which the entire bowel movement cannot be controlled. Diet changes and elimination of certain medications can help patients to regain bowel control. Treatment involves a combination of medication, biofeedback, and exercise.
IBS-D Irrititable Bowel Syndrome with Diarrhea
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include
- intestinal gas (flatulence),
- loose stools,
- frequent stools,
- abdominal pain,
- diarrhea, and
New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms of:
- Abdominal pain
- Increased gas (flatulence)
- Abdominal cramping
- Food intolerance
Two new tests are now available that may help diagnose irritable bowel syndrome with diarrhea and constipation (IBS-M) and irritable bowel syndrome with diarrhea (IBS-D). Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Loperamide (Imodium) is a medication for the treatment and relief of acute, chronic, or travler's diarrhea. Imodium usually cures diarrhea in a couple of days. Common side effects of Imodium are fatigue, dizziness, abdominal pain, and constipation. If diarrhea lasts longer, contact your doctor. Imodium also has the potential to be abused by substance abuse addicts.
Lymphocytic ColitisMicroscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps. Microscopic colitis is diagnosed through biopsies of several areas of the colon. There is no standardized treatment for microscopic colitis; however, eliminating NSAIDs, and treatment medications such as Imodium, Lomotil, Petpo-Bismol, Entocort EC, and mesalamine (Asacol) have been helpful in some individuals.
Travel MedicineTravelers should prepare for their trip by visiting their physician to get the proper vaccinations and obtain the necessary medication if they have a medical condition or chronic disease. Diseases that travelers may pick up from contaminated water or food, insect or animal bites, or from other people include:
- meningococcal meningitis,
- yellow fever,
- hepatitis A,
- typhoid fever,
- polio, and
Traveler's DiarrheaTravelers' diarrhea is generally contracted by eating contaminated food or drinking contaminated water. Food is the primary source of travelers' diarrhea. Enterotoxigenic E. coli is the cause of up to 70% of all cases of travelers' diarrhea. There are five unique classes of E. coli that causes gastroenteritis. Other bacteria responsible for travelers' diarrhea include Campylobacter, jejuni, shigella, and salmonella. Viruses such as rotavirus and Norwalk virus (norovirus) and giardia lamblia a parasite may cause travelers' diarrhea. Prevention is careful eating and drinking of water.