Reviewed on 6/11/2021
Other Name(s):

Acide Diméthylaminoacétique, Dimethyl Glycine, Diméthylglycine, Dimethylglycine HCl, Diméthylglycine HCl, (Dimethylamino)acetic Acid, Dimetilglicina, DMG, DMG HCl, N,N-dimethylaminoacetic Acid, N,N-dimethylglycine, N,N-diméthylglycine, N,N Dimethylglycine HCl, N,N Diméthylglycine HCl, N-methylsarcosine.


Dimethylglycine is an amino acid, a building block for protein. It is found in the body in very small amounts and for only seconds at a time. People use dimethylglycine to make medicine.

Dimethylglycine is used for attention deficit-hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory disorders, pain and swelling (inflammation), cancer, alcoholism, and drug addiction. It is also used to improve speech and behavior in autism, nervous system function, liver function, the body's use of oxygen, and athletic performance. Some people use it to reduce stress and the effects of aging, as well as boost the immune system's defenses against infection. Dimethylglycine is also used to lower blood cholesterol and triglycerides, and to help bring blood pressure and blood sugar into normal range.

In the 1980s, a federal court in Chicago banned the interstate sale of a brand of dimethylglycine, stating that it was an unsafe food additive.

How does it work?

Dimethylglycine might help improve the way the body's immune system works.


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Uses & Effectiveness

Possibly Ineffective for...

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of dimethylglycine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Dimethylglycine might be safe to use short-term, up to 28 days. The safety of long-term use is unknown.


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Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of dimethylglycine during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of dimethylglycine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for dimethylglycine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Bolman WM, Richmond JA. A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord 1999;29:191-4. View abstract.

Freed WJ. N,N-dimethylglycine, betaine and seizures [letter]. Arch Neurol 1984;41:1129-30. View abstract.

Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav 1985;22:641-3. View abstract.

Gascon G, Patterson B, Yearwood K, Slotnick H. N,N-dimethylglycine and epilepsy. Epilepsia 1989;30:90-3. View abstract.

Graber CD, Goust JM, Glassman AD, et al. Immunomodulating properties of dimethylglycine in humans. J Infect Dis 1981;143:101-5. View abstract.

Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc 1982;14:424-7. View abstract.

Herbert V. N,N-dimethylglycine for epilepsy [letter]. N Engl J Med 1983;308:527-8.

Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res 1989;222:343-50. View abstract.

Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990;115:481-6. View abstract.

Roach ES, Carlin L. N,N dimethylglycine for epilepsy [letter]. N Engl J Med 1982;307:1081-2.

Tonda ME, Hart LL. N,N-dimthylglycine and L-carnitine as performance enhancers in athletes. Ann Pharmacother 1992;26:935-7.

Ward TN, Smith EB, Reeves AG. Dimethylglycine and reduction of mortality in penicillin-induced seizures [letter]. Ann Neurol 1985;17:213.

Weiss RC. Immunologic responses in healthy random-source cats fed N,N-dimethylglycine-supplemented diets. Am J Vet Res 1992;53:829-33. View abstract.