What are the differences between Dilaudid and Percocet?

What is Dilaudid? What is Percocet? How do they relieve pain?

  • Dilaudid (hydromorphone hydrochloride) is an opioid narcotic pain reliever similar to oxycodone, morphine, methadone, fentanyl, and other opioids. Dilaudid, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain and reduce the perception of pain.
  • Percocet (oxycodone and acetaminophen) is a combination of a strong narcotic pain-reliever and cough suppressant, and a non-narcotic pain reliever and fever reducer. Oxycodone does not eliminate the sensation of pain, but decreases discomfort by increasing tolerance to pain. Oxycodone also causes sedation and respiratory depression. Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately.

What are the uses for Dilaudid vs. Percocet?

  • Hydromorphone is used for management of acute pain and moderate-to-severe chronic pain in patients when the use of an opioid is appropriate.
  • Percocet is prescribed for the relief of moderate to moderately severe pain.

What are the side effects of Dilaudid vs. Percocet?

Dilaudid Black Box Warning

BLACK BOX WARNING: Hydromorphone (generic name for Dilaudid)

  • Dilaudid-HP Injection should not be confused with other types of Dilaudid injections or other opioids, as overdose and death could result.
  • Avoid dosing errors from confusion between mg and mL when dispensing, prescribing, or administering the oral solution. Dosing errors can result in accidental overdose and death.
  • Hydromorphone exposes patients to risks of addictions, abuse, and misuse, which can lead to overdose and death.
  • Patients should be monitored closely because serious, life-threatening, or fatal respiratory depression may occur.
  • Prolonged use of hydromorphone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. Pregnant woman should be advised of the risk of neonatal opioid withdrawal syndrome and appropriate treatment should be available.
  • Combining opioids with benzodiazepines, alcohol, or other central nervous system (CNS) depressants may result in severe sedation, respiratory depression, coma, and death.

Dilaudid side effects

Common side effects

Other serious side effects:

  • Other serious and important side effects of Dialudid are respiratory depression and trouble breathing.
  • Since Dialudid is a controlled narcotic, it carries a box warning of respiratory depression and abuse potential. Use with alcohol or other medications affecting central nervous system can worsen respiratory depression and may lead to death.

Percocet side effects

The most frequent adverse reactions of Percocet (brand name for oxycodone/acetaminophen) include:

Other important side effects include:

  • Drowsiness
  • Constipation
  • Spasm of the ureter, which can lead to difficulty in urinating

Possible serious side effects include:

Percocet can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Percocet can impair thinking and the physical abilities required for driving or operating machinery.

Are Dilaudid and Percocet addictive?

Dilaudid and oxycodone (the narcotic drug in Percocet) both can be addicting even at doses prescribed. Caution should be used with these medications in individuals who have addiction problems.

What is the dosage for Dilaudid vs. Percocet?

Dilaudid dosage

  • Immediate-release tablets: Take 2 to 4 mg tablets by mouth every 4 to 6 hours as needed. Increase to 8 mg after careful observation and if needed to control pain.
  • Extended-release tablets: Start after discontinuation of all other opioid extended-release tablets. Dosed once-daily, individualized based on prior opioid therapy.
  • Injections: Give 1 to 2 mg intramuscularly or subcutaneously every 2 to 3 hours as needed. Give 0.2 to 1 mg intravenously over 2 to 3 minutes every 2 to 3 hours as needed.
  • Oral solution: Give 2.5 to 10 mg every 3 to 6 hours as needed.
  • Rectal suppository: Insert one 3 mg suppository rectally every 6 to 8 hours OR3 to 6 mg rectally every 3 to 4 hours, when appropriate.
  • Safe and effective use of hydromorphone in children has not been established.

Percocet dosage

  • The dose of Percocet (oxycodone/acetaminophen) is variable and depends on the needs of the patient and specific circumstances.
  • The usual dose is one tablet every six hours as needed.
  • The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer

What drugs interact with Dilaudid and Percocet?

Dilaudid drug interactions

  • Dilaudid should be used very cautiously with medications that depress the central nervous system (for example, hypnotics, anesthetics, tranquilizers, phenothiazines, and alcohol).
  • Dilaudid should be used with caution with mixed agonist/antagonist opioid analgesics (for example, pentazocine, nalbuphine, butorphanol, and buprenorphine) because it may take away the analgesic effect of hydromorphone.

Percocet drug interactions

Are Dilaudid and Percocet safe to take during pregnancy or while breastfeeding?

Dilaudid safety

  • There are no adequate studies of hydromorphone to determine safe and effective use in pregnant women.
  • Low levels of opioid medications may be excreted in breast milk; therefore, it should not be used in nursing mothers.

Percocet safety

  • Safety of oxycodone/acetaminophen during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period may exhibit respiratory depression or withdrawal symptoms.
  • Small amounts of oxycodone are secreted in breast milk and may cause side effects in the newborn.

SLIDESHOW

Rheumatoid Arthritis Exercises: Joint-Friendly Workouts See Slideshow

Summary

Dilaudid (brand name hydromorphone HCI) and Percocet (a combination of oxycodone and acetaminophen) are opioid narcotic pain medications. Dilaudid and Percocet are used to treat patients with moderate to severe pain when other pain therapies have not provided pain relief. Dilaudid and Percocet have similar side effects like dizziness, lightheadedness, nausea, itching and sleepiness.

Treatment & Diagnosis

Medications & Supplements

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Health Solutions From Our Sponsors

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 12/11/2021
References
FDA Prescribing Information.