- Dilaudid vs. Percocet quick comparison
- What is Dilaudid? What is Percocet? How do they relieve pain?
- What are the uses for Dilaudid vs. Percocet?
- Differences between side effects of Dilaudid vs. Percocet
- Are Dilaudid and Percocet addictive?
- What is the dosage for Dilaudid vs. Percocet?
- Which drugs interact with Dilaudid vs. Percocet?
- Are Dilaudid and Percocet safe to take during pregnancy or while breastfeeding?
Dilaudid vs. Percocet quick comparison
- Dilaudid (hydromorphone hydrochloride) and Percocet (oxycodone and acetaminophen) are both opioid narcotic pain relievers.
- Percocet has an additional non-narcotic pain reliever added (acetaminophen) which achieves greater pain relief than either drug taken separately.
- Both Dilaudid and Percocet are available as generic drugs.
- Side effects of both Dilaudid and Percocet are similar and include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, itching. Dilaudid may also cause sweating, flushing, and dry mouth. Percocet may also cause euphoria, rash, drowsiness, and difficulty urinating.
- Serious side effects of both Dilaudid and Percocet include slowed breathing and trouble breathing.
- Combining opioids such as Dilaudid and Percocet with alcohol or other central nervous system depressants may result in severe sedation, respiratory depression, coma, and death.
- Both Dilaudid and Percocet have potential for abuse and addiction. Withdrawal symptoms for both drugs include restlessness, watery eyes, runny nose, yawning, sweating, chills, muscle pain, and dilated pupils.
What is Dilaudid? What is Percocet? How do they relieve pain?
Dilaudid (hydromorphone hydrochloride) is an opioid narcotic pain reliever similar to oxycodone, morphine, methadone, fentanyl, and other opioids. Dilaudid, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain and reduce the perception of pain.
Percocet (oxycodone and acetaminophen) is a combination of a strong narcotic pain-reliever and cough suppressant, and a non-narcotic pain reliever and fever reducer. Oxycodone does not eliminate the sensation of pain, but decreases discomfort by increasing tolerance to pain. Oxycodone also causes sedation and respiratory depression. Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately.
What are the uses for Dilaudid vs. Percocet?
Hydromorphone is used for management of acute pain and moderate-to-severe chronic pain in patients when the use of an opioid is appropriate.
Percocet is prescribed for the relief of moderate to moderately severe pain.
Differences between side effects of Dilaudid vs. Percocet
Dilaudid Black Box Warning
BLACK BOX WARNING: Hydromorphone (generic name for Dilaudid)
- Dilaudid-HP Injection should not be confused with other types of Dilaudid injections or other opioids, as overdose and death could result.
- Avoid dosing errors from confusion between mg and mL when dispensing, prescribing, or administering the oral solution. Dosing errors can result in accidental overdose and death.
- Hydromorphone exposes patients to risks of addictions, abuse, and misuse, which can lead to overdose and death.
- Patients should be monitored closely because serious, life-threatening, or fatal respiratory depression may occur.
- Prolonged use of hydromorphone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. Pregnant woman should be advised of the risk of neonatal opioid withdrawal syndrome and appropriate treatment should be available.
- Combining opioids with benzodiazepines, alcohol, or other central nervous system (CNS) depressants may result in severe sedation, respiratory depression, coma, and death.
Dilaudid side effects
Common side effects
Other serious side effects:
- Other serious and important side effects of Dialudid are respiratory depression and trouble breathing.
- Since Dialudid is a controlled narcotic, it carries a box warning of respiratory depression and abuse potential. Use with alcohol or other medications affecting central nervous system can worsen respiratory depression and may lead to death.
Percocet side effects
The most frequent adverse reactions of Percocet (brand name for oxycodone/acetaminophen) include:
Other important side effects include:
- Spasm of the ureter, which can lead to difficulty in urinating
Possible serious side effects include:
- Severe reduction in blood pressure (hypotension)
- Paralytic ileus
- Serious allergic reactions
- Severe skin reactions
Percocet can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Percocet can impair thinking and the physical abilities required for driving or operating machinery.
Are Dilaudid and Percocet addictive?
Dilaudid and oxycodone (the narcotic drug in Percocet) both can be addicting even at doses prescribed. Caution should be used with these medications in individuals who have addiction problems.
What is the dosage for Dilaudid vs. Percocet?
- Immediate-release tablets: Take 2 to 4 mg tablets by mouth every 4 to 6 hours as needed. Increase to 8 mg after careful observation and if needed to control pain.
- Extended-release tablets: Start after discontinuation of all other opioid extended-release tablets. Dosed once-daily, individualized based on prior opioid therapy.
- Injections: Give 1 to 2 mg intramuscularly or subcutaneously every 2 to 3 hours as needed. Give 0.2 to 1 mg intravenously over 2 to 3 minutes every 2 to 3 hours as needed.
- Oral solution: Give 2.5 to 10 mg every 3 to 6 hours as needed.
- Rectal suppository: Insert one 3 mg suppository rectally every 6 to 8 hours OR3 to 6 mg rectally every 3 to 4 hours, when appropriate.
- Safe and effective use of hydromorphone in children has not been established.
- The dose of Percocet (oxycodone/acetaminophen) is variable and depends on the needs of the patient and specific circumstances.
- The usual dose is one tablet every six hours as needed.
- The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.
Which drugs interact with Dilaudid vs. Percocet?
Dilaudid drug interactions
- Dilaudid should be used very cautiously with medications that depress the central nervous system (for example, hypnotics, anesthetics, tranquilizers, phenothiazines, and alcohol).
- Dilaudid should be used with caution with mixed agonist/antagonist opioid analgesics (for example, pentazocine, nalbuphine, butorphanol, and buprenorphine) because it may take away the analgesic effect of hydromorphone.
Percocet drug interactions
- Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.
- Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
- Drugs which stimulate and also block opioid receptors, for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
- A fatty meal may increase the absorption of oxycodone by 27%.
Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment
Are Dilaudid and Percocet safe to take during pregnancy or while breastfeeding?
- There are no adequate studies of hydromorphone to determine safe and effective use in pregnant women.
- Low levels of opioid medications may be excreted in breast milk; therefore, it should not be used in nursing mothers.
- Safety of oxycodone/acetaminophen during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period may exhibit respiratory depression or withdrawal symptoms.
- Small amounts of oxycodone are secreted in breast milk and may cause side effects in the newborn.
Dilaudid (brand name hydromorphone HCI) and Percocet (a combination of oxycodone and acetaminophen) are
opioid narcotic pain relievers. Dilaudid and Percocet are used to treat patients with moderate to severe pain when other pain therapies have not provided pain relief.
Dilaudid and Percocet have similar side effects like dizziness, lightheadedness, nausea, itching and sleepiness.
Other side effects of Dilaudid include:
Other side effect of Percocet include:
Percocet has possible serious side effects that include:
- Severe low blood pressure
- Serious anaphylactic (allergic) reactions
- Severe skin reactions
Since Dilaudid and Percocet are opioid narcotics, they have the potential for
abuse and addiction. Neither drugs is recommended if you are pregnant and
breastfeeding. Dosage depends upon the patient's health and other any medical
problems they may have. Dilaudid and Percocet interact with other drugs. Talk
with your doctor or pharmacist with questions about any medications you take.
REFERECE: FDA Prescribing Information.
Multimedia: Slideshows, Images & Quizzes
Ovarian Cancer Quiz: Test Your Medical IQ
How common is ovarian cancer and who is at risk? Take our Ovarian Cancer Quiz to learn the causes, symptoms, and treatment for...
Back Pain Quiz: Test Your Back Pain IQ
There are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge...
Melanoma (Skin Cancer) Quiz: Symptoms & Signs
What causes skin cancer? Take our Skin Cancer Quiz to learn about the risks, symptoms, causes, and treatments for this common...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Pancreatic Cancer Symptoms, Causes, and Treatment
Learn about pancreatic cancer signs, symptoms, causes, statistics, treatment and side effects (chemotherapy, radiation, surgery,...
Back Pain: Find Relief, Treat Your Back Pain
Back pain conditions are very common. Learn the truth and get the facts behind myths, remedies, causes and treatment for back...
Colon Cancer: Symptoms, Signs, Screening, Stages
Colorectal cancer (colon cancer) is the cause of many cancer deaths. Learn about the warning signs, symptoms, screening process,...
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Lung Cancer Symptoms, Stages, Treatment
Learn about lung cancer symptoms and treatments. Get more information on small cell lung cancer, non-small cell lung cancer, and...
Ovarian Cancer Symptoms, Signs, Stages
Learn about ovarian cancer symptoms, diagnosis, and treatments. Follow the progression of ovarian cancer stages from stage 1 to...
Prostate Cancer Symptoms, PSA Test, Treatments
Prostate cancer is the most common cancer in men. Learn the signs and symptoms of prostate cancer, along with causes and...
Cervical Cancer Symptoms, Stages, and Treatment
Cervical cancer is commonly caused by human papillomavirus (HPV) infections. Learn about vaccines to prevent cervical cancer. Get...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women...
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy,...
Myofascial Pain Syndrome
Myofascial pain syndrome is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Kidney Pain (Location, Symptoms, Relief)
Kidney pain has a variety of causes and symptoms. Infection, injury, trauma, bleeding disorders, kidney stones, and less common...
Treatment & Diagnosis
Medications & Supplements
- acetaminophen (Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain)
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Tramadol: for Pain (Ultram, Ultram ER, Conzip)
- Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond)
- Narcotic Pain Medications (Opioids, Analgesics, Narcotics)
- hydromorphone (Dilaudid, Dilaudid-5, Dilaudid-HP Injection, Exalgo) for Pain
- Oxycodone vs. Hydrocodone
- Oxycodone vs. Tramadol for Pain
- Percocet vs. Lortab for Pain
- Oxycodone vs. Vicodin (hydrocodone/acetaminophen) for Pain
- Dilaudid vs. Morphine
- Dilaudid vs. Oxycodone
- Percocet vs. Hydrocodone
- Dilaudid vs. Fentanyl (Pain Strength Comparison and Side Effects)
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information.