- Dilaudid vs. Percocet Quick Comparison
- What is Dilaudid? What is Percocet? How do they relieve pain?
- What are the uses for Dilaudid vs. Percocet?
- Differences between side effects of Dilaudid vs. Percocet
- Are Dilaudid and Percocet Addictive?
- What is the dosage for Dilaudid vs. Percocet?
- Which drugs interact with Dilaudid vs. Percocet?
- Are Dilaudid and Percocet safe to take during pregnancy or while breastfeeding?
Dilaudid vs. Percocet Quick Comparison
- Dilaudid (hydromorphone hydrochloride) and Percocet (oxycodone and acetaminophen) are both opioid narcotic pain relievers.
- Percocet has an additional non-narcotic pain reliever added (acetaminophen) which achieves greater pain relief than either drug taken separately.
- Both Dilaudid and Percocet are available as generic drugs.
- Side effects of both Dilaudid and Percocet are similar and include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, itching. Dilaudid may also cause sweating, flushing, and dry mouth. Percocet may also cause euphoria, rash, drowsiness, and difficulty urinating.
- Serious side effects of both Dilaudid and Percocet include slowed breathing and trouble breathing.
- Combining opioids such as Dilaudid and Percocet with alcohol or other central nervous system depressants may result in severe sedation, respiratory depression, coma, and death.
- Both Dilaudid and Percocet have potential for abuse and addiction. Withdrawal symptoms for both drugs include restlessness, watery eyes, runny nose, yawning, sweating, chills, muscle pain, and dilated pupils.
What is Dilaudid? What is Percocet? How do they relieve pain?
Dilaudid (hydromorphone hydrochloride) is an opioid narcotic pain reliever similar to oxycodone, morphine, methadone, fentanyl, and other opioids. Dilaudid, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain and reduce the perception of pain.
Percocet (oxycodone and acetaminophen) is a combination of a strong narcotic pain-reliever and cough suppressant, and a non-narcotic pain reliever and fever reducer. Oxycodone does not eliminate the sensation of pain, but decreases discomfort by increasing tolerance to pain. Oxycodone also causes sedation and respiratory depression. Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately.
What are the uses for Dilaudid vs. Percocet?
Hydromorphone is used for management of acute pain and moderate-to-severe chronic pain in patients when use of an opioid is appropriate.
Percocet is prescribed for the relief of moderate to moderately-severe pain.
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Differences between side effects of Dilaudid vs. Percocet
Dilaudid Black Box Warning
BLACK BOX WARNING: Hydromorphone (generic name for Dilaudid)
- Dilaudid-HP Injection should not be confused with other types of Dilaudid injections or other opioids, as overdose and death could result.
- Avoid dosing errors from confusion between mg and mL when dispensing, prescribing, or administering the oral solution. Dosing errors can result in accidental overdose and death.
- Hydromorphone exposes patients to risks of addictions, abuse, and misuse, which can lead to overdose and death.
- Patients should be monitored closely because serious, life-threatening, or fatal respiratory depression may occur.
- Prolonged use of hydromorphone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. Pregnant woman should be advised of the risk of neonatal opioid withdrawal syndrome and appropriate treatment should be available.
- Combining opioids with benzodiazepines, alcohol, or other central nervous system (CNS) depressants may result in severe sedation, respiratory depression, coma, and death.
Dilaudid side effects
Common side effects
Other serious side effects:
- Other serious and important side effects of Dialudid are respiratory depression and trouble breathing.
- Since Dialudid is a controlled narcotic, it carries a box warning of respiratory depression and abuse potential. Use with alcohol or other medications affecting central nervous system can worsen respiratory depression and may lead to death.
Percocet side effects
The most frequent adverse reactions of Percocet (brand name for oxycodone/acetaminophen) include:
Other important side effects include:
- Spasm of the ureter, which can lead to difficulty in urinating
Possible serious side effects include:
- Severe reduction in blood pressure (hypotension)
- Paralytic ileus
- Serious allergic reactions
- Severe skin reactions
Percocet can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Percocet can impair thinking and the physical abilities required for driving or operating machinery.
Are Dilaudid and Percocet Addictive?
Dilaudid and oxycodone (the narcotic drug in Percocet) both can be addicting even at doses prescribed. Caution should be used with these medications in individuals who have addiction problems.
What is the dosage for Dilaudid vs. Percocet?
- Immediate-release tablets: Take 2 to 4 mg tablets by mouth every 4 to 6 hours as needed. Increase to 8 mg after careful observation and if needed to control pain.
- Extended-release tablets: Start after discontinuation of all other opioid extended-release tablets. Dosed once-daily, individualized based on prior opioid therapy.
- Injections: Give 1 to 2 mg intramuscularly or subcutaneously every 2 to 3 hours as needed. Give 0.2 to 1 mg intravenously over 2 to 3 minutes every 2 to 3 hours as needed.
- Oral solution: Give 2.5 to 10 mg every 3 to 6 hours as needed.
- Rectal suppository: Insert one 3 mg suppository rectally every 6 to 8 hours OR3 to 6 mg rectally every 3 to 4 hours, when appropriate.
- Safe and effective use of hydromorphone in children has not been established.
- The dose of Percocet (oxycodone/acetaminophen) is variable and depends on the needs of the patient and specific circumstances.
- The usual dose is one tablet every six hours as needed.
- The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.
Which drugs interact with Dilaudid vs. Percocet?
Dilaudid drug interactions
- Dilaudid should be used very cautiously with medications that depress the central nervous system (for example, hypnotics, anesthetics, tranquilizers, phenothiazines, and alcohol).
- Dilaudid should be used with caution with mixed agonist/antagonist opioid analgesics (for example, pentazocine, nalbuphine, butorphanol, and buprenorphine) because it may take away the analgesic effect of hydromorphone.
Percocet drug interactions
- Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.
- Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
- Drugs which stimulate and also block opioid receptors, for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
- A fatty meal may increase the absorption of oxycodone by 27%.
Are Dilaudid and Percocet safe to take during pregnancy or while breastfeeding?
- There are no adequate studies of hydromorphone to determine safe and effective use in pregnant women.
- Low levels of opioid medications may be excreted in breast milk; therefore, it should not be used in nursing mothers.
- Safety of oxycodone/acetaminophen during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period may exhibit respiratory depression or withdrawal symptoms.
- Small amounts of oxycodone are secreted in breast milk and may cause side effects in the newborn.
Dilaudid (brand name hydromorphone HCI) and Percocet (a combination of oxycodone and acetaminophen) are
opioid narcotic pain relievers. Dilaudid and Percocet are used to treat patients with moderate to severe pain when other pain therapies have not provided pain relief.
Dilaudid and Percocet have similar side effects like dizziness, lightheadedness, nausea, itching and sleepiness.
Other side effects of Dilaudid include:
Other side effect of Percocet include:
Percocet has possible serious side effects that include:
- Severe low blood pressure
- Serious anaphylactic (allergic) reactions
- Severe skin reactions
Since Dilaudid and Percocet are opioid narcotics, they have the potential for
abuse and addiction. Neither drugs is recommended if you are pregnant and
breastfeeding. Dosage depends upon the patient's health and other any medical
problems they may have. Dilaudid and Percocet interact with other drugs. Talk
with your doctor or pharmacist with questions about any medications you take.
REFERECE: FDA Prescribing Information.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top Dilaudid vs. Percocet Related Articles
Acetaminophen is a drug that reduces fever and relieves pain. It is available alone, or in combination with hundreds of other drugs available both over-the-counter (without a prescription) or that that may require a prescription from your doctor, for example, acetaminophen and hydrocodone (Vicodin, Norco) or acetaminophen and oxycodone (Percocet).
Acetaminophen treats a variety of diseases or other medical problems that cause pain or fever. Examples of conditions acetaminophen treats include, headache, minor arthritis pain, back pain, tooth pain, menstrual cramps, PMS, osteoarthritis, common cold, tension headache, chronic pain, hip pain, shoulder and neck pain, sore throat, sinus infection, teething, TMJ, bites and stings, and sprains and strains.
Acetaminophen generally has no side effects when taken as prescribed. When side effects are experienced, the most common are headache, rash, and nausea.
In 2014, the FDA recommended that doctors and other health care professionals only prescribe acetaminophen in doses of 325 mg or less. This warning highlights the potential for allergic reactions, for example, face, mouth, and throat swelling, difficulty breathing, itching, or rash. This action also will help reduce the risk of severe liver injury and serious allergic reactions associated with this drug. Other possible serious side effects adverse effects include anemia, kidney damage, thrombocytopenia (a reduced number of platelets in the blood), and liver problems.
Other patient information. Do not take more than one product that contains acetaminophen at the same time. Do not take more than one acetaminophen-containing drug than directed. Do not drink alcohol while taking medicine that contains acetaminophen due to severe liver damage.
REFERENCE: FDA Prescribing Information.
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Narcotic analgesics (also called opioids) are medications prescribed to treat moderate to severe pain. Examples (list) include:
Side effects include:
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Oxycodone (OxyContin, Roxicodone, Oxecta) is a narcotic pain-reliever prescribed for moderate to moderately severe pain. Some side effects include:
Drug interactions, dosing, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
oxycodone and acetaminophen
Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet) is a drug prescribed for the relief of moderate to moderately-severe pain. Common side effects may include:
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication. The brand name Endocet has been discontinued.
Other brand names for oxycodone and acetaminophen are Roxicet, Tylox, Oxycet, Roxilox.
Oxycodone vs Tramadol for Pain
Oxycodone and tramadol are prescription medications used to manage acute and chronic moderate to severe pain. Oxycodone is an opiate (narcotic) derived drug whereas tramadol is a man-made synthetic drug. Tramadol is not a narcotic, and it is not a nonsteroidal anti-inflammatory drug (NSAIDs). Some of the side effects of oxycodone and tramadol are the same, for example:
- Dry mouth
Serious side effects for oxycodone and tramadol differ. Oxycodone and tramadol are habit forming drugs and patients may become addicted. Withdrawal symptoms include:
Drug interactions, dosing, and pregnancy and breastfeeding safety information differs for these drugs and should be reviewed prior to administration.
Oxycodone vs. Hydrocodone
Oxycodone and hydrocodone are prescription opioid pain medications. Both drugs have similar uses and side effects, for example:
Both drugs also are available in combination with other drugs. Examples of brand names include:
- Zohydro ER
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Tramadol hydrochloride (Ultram) is a centrally acting opioid painkiller (analgesic) indicated for the management of moderate to moderately severe pain in adults. Pain relief (analgesia) begins approximately within one hour after administration and reaches a peak in approximately two to three hours. Apart from analgesia, tramadol administration may produce a constellation of symptoms (including dizziness, somnolence, nausea, constipation, sweating and pruritus) similar to that of other opioids. In contrast to morphine, tramadol has not been shown to cause histamine release. At therapeutic doses, tramadol has no effect on heart rate, left-ventricular function or cardiac index. Orthostatic hypotension has been observed.
Side effects of tramadol include:
- Dizziness/spinning sensation (vertigo)
- Central nervous system (CNS) stimulation
- Weakness/lack of energy
- Dry Mouth
The dosage of tramadol should be started at 25 mg/day in the morning, and adjusted in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg four times daily). Thereafter the total daily dose may be increased by 50 mg as tolerated every 3 20days to reach 200 mg/day (50 mg four times daily). After adjustment, tramadol 50 to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day. Tramadol is supplied in 50 mg tablets.
Withdrawal symptoms may occur if tramadol is discontinued abruptly. Reported withdrawal symptoms have included:
- Upper respiratory symptoms
- Goose bumps (piloerections)
- Rarely hallucinations
There are reports of acute overdosage with tramadol. Signs and symptoms can manifest by respiratory depression, sleepiness progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, seizures, slow heart rate, low blood pressure (hypotension), cardiac arrest, and death. Deaths due to overdose have been reported with abuse and misuse of tramadol.
Tramadol may interact with quinidine, fluoxetine, paroxetine, amitriptyline, ketoconazole, erythromycin, SSRIs, MAOIs, triptans, linezolid, lithium, St. John's wort, carbamazepine, rifampin, and digoxin. There are no adequate and well-controlled studies of tramadol in pregnant women. Tramadol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonatal seizures, neonatal withdrawal syndrome, fetal death and stillbirth have been reported during post-marketing. Tramadol is not recommended for obstetrical preoperative medication or for post-delivery analgesia in nursing mothers because its safety in infants and newborns has not been studied.
Other drugs in the same class as tramadol include codeine hydrocodone (Zohydro ER), oxycodone (OxyContin, Roxicodone), methadone hydromorphone (Dilaudid, Exalgo), morphine (Avinza, Kadian, MSIR, MS Contin), fentanyl (Actiq, Duragesic). If you have questions about this drug talk to your doctor, pharmacist, or other medical professional.
REFERENCE: FDA Prescribing Information for tramadol.