Medical Definition of Dihydroorotate dehydrogenase

Dihydroorotate dehydrogenase: An enzyme necessary to pyrimidine synthesis and therefore essential to the production of DNA and RNA. The drug leflunomide (Arava), an immunomodulatory agent, acts by specifically inhibiting dihydroorotate dehydrogenase.

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Last Editorial Review: 9/7/2018