- Digestive enzymes vs. omeprazole (Prilosec): What's the difference?
- What are digestive enzymes and omeprazole?
- What are the side effects of digestive enzymes and omeprazole?
- What is the dosage of digestive enzymes vs. omeprazole?
- What drugs interact with digestive enzymes and omeprazole?
- Are digestive enzymes and omeprazole safe to use while pregant or breastfeeding?
Digestive enzymes vs. omeprazole (Prilosec): What's the difference?
- Pancreatic enzyme products (PEPs) and omeprazole (Prilosec) are used to treat different types of gastrointestinal problems.
- Pancreatic enzyme products are used when the pancreas is unable to produce enough digestive enzymes to treat people with pancreatic diseases, such as cystic fibrosis, Shwachman-Diamond syndrome, chronic pancreatitis, pancreatic cancer or tumors, and removal of all or part of the pancreas. PEPs may also be used in gastrointestinal disorders, including Celiac disease, Crohn's disease, and certain cases of poor digestion that are associated with deficiencies in pancreatic enzymes.
- Omeprazole is used to treat ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection.
- Pancreatic enzyme products and omeprazole belong to different drug classes. Pancreatic enzyme products are a combination of enzymes normally produced by the pancreas and omeprazole is a proton pump inhibitor (PPI).
- Side effects of pancreatic enzyme products and omeprazole that are similar include headache, diarrhea, nausea, vomiting, and dizziness.
- Side effects of pancreatic enzyme products that are different from omeprazole include stomach pain, gas, constipation, cough, sore throat, upset stomach, neck pain, stuffy nose, heartburn, ear pain, and nosebleed.
- Side effects of omeprazole that are different from pancreatic enzyme products include rash, nervousness, abnormal heartbeat, muscle pain, and weakness.
What are digestive enzymes and omeprazole?
Digestive enzymes are complex proteins naturally produced by the pancreas to help digest and break down the foods we eat. Oral digestive enzymes are used when the pancreas is unable to produce enough digestive enzymes. The main digestive enzymes are proteases for digesting proteins, lipases for digesting fats, and amylases for digesting carbohydrates. Pancreatic enzyme products (PEPs) are used in people with pancreatic diseases, such as cystic fibrosis, Shwachman-Diamond syndrome, chronic pancreatitis, pancreatic cancer or tumors, and removal of all or part of the pancreas. PEPs may also be used in gastrointestinal disorders, including Celiac disease, Crohn's disease, and certain cases of poor digestion that are associated with deficiencies in pancreatic enzymes.
Omeprazole (Prilosec) is a proton pump inhibitor (PPI) used to treat ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection. Other PPIs include lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome, which are all caused by stomach acid. Omeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.

SLIDESHOW
Super Tips to Boost Digestive Health: Bloating, Constipation, and More See SlideshowWhat are the side effects of digestive enzymes and omeprazole?
Digestive enzymes
Although rare, some patients can experience life-threatening allergic reactions when taking this medicine. Patients should stop their medication immediately and seek emergency medical help if they have any of the following signs or symptoms.
- Difficulty breathing or talking
- Swelling of the mouth, face, lips, tongue, or throat
- Chest tightness
- Rash or hives
- Itching
- Red, swollen, blistered, or peeling skin
- Wheezing
Other side effects of digestive enzymes include:
- Stomach pain
- Headache
- Gas
- Constipation
- Cough
- Sore throat
- Diarrhea
- Upset stomach
- Nausea or vomiting
- Neck pain
- Stuffy nose
- Heartburn
- Ear pain
- Dizziness
- Nosebleed
This medication can increase the risk of developing a rare but serious bowel problem called fibrosing colonopathy in which there is localized inflammation and scarring in the colon. Patients are advised to call their doctor right away if they have very bad
Many digestive enzymes are derived from pork and, therefore, should not be used by patients who are allergic to pork.
Omezprazole
Omeprazole like other PPIs is well tolerated. The most common side effects are:
Other important side effects include:
- Nervousness
- Abnormal heartbeat
- Muscle pain
- Weakness
- Leg cramps and water retention, which occur infrequently
Each packet of Zegerid powder for oral suspension contains 460 mg of sodium and each capsule contains 304 mg of sodium. This should be taken into consideration in patients who need a sodium-restricted diet.
Proton pump inhibitors may increase the risk of Clostridium difficile infection. High doses and long-term use (1 year or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin).
Long-term use of PPIs has also been associated with low levels of magnesium (hypomagnesemia). Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.
Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.
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What is the dosage of digestive enzymes vs. omeprazole?
Digestive enzymes
Digestive enzymes are available over-the-counter (OTC) or by prescription.
- OTC products are not approved by the FDA and should not be used with the intent to cure or treat any aliments.
- OTC digestive enzymes are mainly used as dietary supplements to help with digestion.
- OTC dietary supplements are not regulated by the FDA and may contain impurities and varying quantities of active ingredients.
Speak to your doctor or pharmacist if you are interested in starting an OTC regimen.
Prescription digestive enzymes come in various formulations and may contain different amounts of individual digestive enzymes. Therefore, prescription digestive enzymes are not clinically interchangeable and are not considered bioequivalent by the FDA.
Omeprazole
For ulcers, GERD, erosive esophagitis and eradication of H. pylori, the recommended dose for adults is 20 to 40 mg daily. Ulcer healing usually occurs within 4 to 8 weeks.
H. pylori infections are treated for 10 to 28 days.
The usual dose for prevention of upper gastrointestinal bleeding in critically ill patients is 40 mg daily for 14 days.
Omeprazole is used for treating heartburn for up to 2 weeks, and the usual dose is 20 mg daily.
For the management of Zollinger-Ellison syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on either the response of symptoms or the actual measurement of acid production. Doses greater than 80 mg should be divided. Doses up to 120 mg 3 times a day have been used in the treatment of Zollinger-Ellison Syndrome.
For maximal efficacy, omeprazole tablets should be taken before meals, swallowed whole and should not be crushed, chewed, or opened.
What drugs interact with digestive enzymes and omeprazole?
Digestive enzymes
The effectiveness of oral digestive enzymes may decrease when they are given with antacids containing calcium or magnesium.
Digestive enzymes containing amylase or other carbohydrate digesting enzymes may reduce the effectiveness of alpha-glucosidase inhibitors -- for example, acarbose (Precose), miglitol (Glyset) -- a class of oral anti-diabetes medications that are used to reduce the activity of the carbohydrate digesting enzymes.
Omeprazole
Omeprazole potentially can increase the concentrations in blood of diazepam (Valium), warfarin (Coumadin), and phenytoin (Dilantin) by decreasing the elimination of these drugs by the liver.
The absorption of certain drugs may be affected by stomach acidity. Therefore, omeprazole as well as other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may reduce the effectiveness of ketoconazole or increase digoxin toxicity.
Through unknown mechanisms, omeprazole may increase blood levels of saquinavir and reduce blood levels of nelfinavir and atazanavir, drugs that are used for treating patients with infection caused by the human immunodeficiency virus (HIV). Accordingly, the dose of saquinavir may need to be reduced to avoid toxicity, and the doses of nelfinavir and atazanavir may need to be increased to maintain efficacy.
Clopidogrel (Plavix) is converted to its active form by enzymes in the liver. Omeprazole reduces the activity of these enzymes and potentially can reduce the activity of clopidogrel. Omeprazole should not be used with clopidogrel.
Omeprazole increases the concentration of cilostazol (Pletal). The dose of cilostazol should be reduced from 100 mg twice daily to 50 mg twice daily when given with omeprazole.
Omeprazole may increase blood levels of methotrexate (Rheumatrex, Trexall) and tacrolimus (Prograf).
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Are digestive enzymes and omeprazole safe to use while pregant or breastfeeding?
Digestive enzymes
Oral digestive enzymes have not been adequately studied in pregnant women. Oral digestive enzymes should only be used during pregnancy if the potential benefits to the mother outweigh the potential risks to the unborn baby.
It is not known whether oral digestive enzymes are excreted into breast milk. Pancreatic enzymes mostly act locally in the gastrointestinal tract and are generally not absorbed into the bloodstream to make their way to the fetus.
Omeprazole
Use of omeprazole in pregnant women has not been adequately evaluated. Omeprazole should only be used during pregnancy if the benefits justify the unknown risks.
Omeprazole is excreted in breast milk and potentially could cause adverse effects in the infant.
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Summary
Pancreatic enzyme products (PEPs) and omeprazole (Prilosec) are used to treat different types of gastrointestinal problems. Digestive enzymes are complex proteins naturally produced by the pancreas to help digest and break down the foods we eat. Oral digestive enzymes are used when the pancreas is unable to produce enough digestive enzymes. Oomeprazole is a proton pump inhibitor (PPI) used to treat ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, duodenitis, erosive esophagitis, heartburn, and H. pylori infection.
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Causes of heartburn include dietary habits, lifestyle habits, and medical causes.
Treatments for heartburn include lifestyle changes, OTC medication,prescription medication, and surgery.
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Learn the symptoms of heartburn and which foods cause heartburn or GERD. Discover home remedies and which foods may provide treatment for heartburn relief.Acid Reflux (Heartburn, GERD): Symptoms & Remedies
Heartburn is a symptom of acid reflux that causes chest pain when stomach acid backs up into the esophagus. Heartburn symptoms may mimic chest pain that occurs during a heart attack. Gastroesophageal reflux disease (GERD) may produce other symptoms.Heartburn vs. Acid Reflux (Differences and Similarities)
Heartburn and acid reflux are not the same thing. Heartburn is actually a symptom of acid reflux. Heartburn gets its name because it feels like a burning sensation around the heart. Another symptom that occurs with heartburn is a bitter or sour taste in the mouth, usually when you eat or lye down. Heartburn affects more than 60 million people in the US at least once a month. Acid reflux, or GERD, occurs when stomach acid backs up into the esophagus, which irritates it. Heartburn is just one symptom of acid reflux. Other symptoms of acid reflux include:
- Belching
- Nausea after eating
- A feeling of fullness during or after eating
- Abdominal bloating
- Upset stomach
- Belching
- Wheezing
- Reflux laryngitis
- A tightness in the throat
- Problems swallowing
- Indigestion
- In some people, vomiting
Causes of acid reflux and heartburn include:
- Being obese
- Slouching (poor posture)
- Medications like calcium channel blockers, theophylline, nitrates, and antihistamines
- Foods and drinks like caffeine, citrus fruits and vegetables, alcohol, and chocolate
- Pregnancy
- Diabetes
- Increase in stomach acid
- Eating a heavy meal
- Eating before bed
The treatment for heartburn and acid reflux is to treat the underlying cause, for example, GERD, with over-the-counter (OTC) medicine, prescription medicine, natural remedies, and lifestyle changes like a eating a healthy, less fatty, spicy diet, not eating big meals, not eating before bed, and getting regular exercise to improve your posture.
Sometimes a heart attack can mimic heartburn and acid reflux because they feel very similar. If you have symptoms of chest pain, tightness in the chest, heartburn, acid reflux, jaw, tooth, or head pain; shortness of breath, nausea, vomiting, sweating, discomfort in the upper middle of the abdomen, arm or upper back pain, or the general feeling of being ill, go to the nearest Emergency Department immediately because these are the symptoms of a heart attack.
REFERENCES:
American College of Gastroenterology. "Acid Reflux." 2017.
<http://patients.gi.org/topics/acid-reflux/>
familydoctor.org. "Heartburn." Updated: Mar 2014.
<https://familydoctor.org/condition/heartburn/>
National Library of Medicine; PubMed Health. "Heartburn and GERD: Treatment options for GERD." Updated: Nov 18, 2015.
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