- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: dicyclomine
Brand Name: Bentyl
Drug Class: Anticholinergics
What is dicyclomine, and what is it used for?
Anticholinergic drugs block the effects of acetylcholine, the chemical transmitter that nerves release in order to cause muscles to contract. They prevent contraction of muscles by blocking the acetylcholine receptors on the muscle cells. Anticholinergic drugs also have a direct relaxing effect on muscle. Dicyclomine is used to reduce contraction of the muscles in the intestines.
Dicyclomine was approved by the FDA in 1950.
What are the side effects of dicyclomine?
Common side effects include:
- dry mouth (xerostomia),
- blurred vision,
- increased heart rate,
- heart palpitations,
- difficulty urinating, and
Other important side effects include:
What is the dosage for dicyclomine?
- The recommended starting oral dose of dicyclomine is 20 mg given 4 times daily. The dose can be increased to 40 mg 4 times daily.
- The recommended intramuscular injection is 10 to 20 mg 4 times daily.
- The intramuscular injection is only used for 1 to 2 days if a patient cannot take capsules or tablets.
What drugs interact with dicyclomine?
Anticholinergics antagonize the effects of antiglaucoma agents and may increase intraoccular pressure. Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. Use of Bentyl in patients with glaucoma is not recommended.
Other Drugs with Anticholinergic Activity
The following agents may increase certain actions or side effects of anticholinergic drugs including Bentyl:
- antiarrhythmic agents of Class I (for example, quinidine),
- antipsychotic agents (for example, phenothiazines),
- MAO inhibitors,
- narcotic analgesics (for example, meperidine),
- nitrates and nitrites,
- sympathomimetic agents,
- tricyclic antidepressants, and
- other drugs having anticholinergic activity.
Other Gastrointestinal Motility Drugs
Interaction with other gastrointestinal motility drugs may antagonize the effects of drugs that alter gastrointestinal motility, such as metoclopramide.
Effect of Antacids
Because antacids may interfere with the absorption of anticholinergic agents including Bentyl, simultaneous use of these drugs should be avoided.
Effect on Absorption of Other Drugs
Anticholinergic agents may affect gastrointestinal absorption of various drugs by affecting on gastrointestinal motility, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentration may result.
Effect on Gastric Acid Secretion
The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion.
Is dicyclomine safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of the effect of dicyclomine in pregnant women at recommended doses (80-160 mg/day). Observation of women who received dicyclomine (up to 40 mg/day) containing products during the first trimester of pregnancy did not reveal any increased risk of harm to the fetus.
What else should I know about dicyclomine?
What preparations of dicyclomine are available?
- Capsules: 10 mg. Tablets: 20 mg. Syrup: 10 mg/5 mL. Injection (Intramuscular): 10 mg/ mL
How should I keep dicyclomine stored?
- Capsules, tablets, and injection should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Injection should be protected from freezing.
Dicyclomine is a drug prescribed for the treatment of irritable bowel syndrome (IBS). Common side effects include dry mouth (xerostomia), blurred vision, confusion, agitation, increased heart rate, heart palpitations, constipation, difficulty urinating, and seizures. Consult your doctor before taking if pregnant or breastfeeding.
Multimedia: Slideshows, Images & Quizzes
IBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment
What is irritable bowel syndrome (IBS)? Learn about symptoms, causes, and foods that trigger IBS. Get lifestyle tips for managing...
Diverticulitis (Diverticulosis) Symptoms, Diet, Treatment
Diverticulitis (diverticulosis) is a condition in which the diverticulum or diverticula rupture in the colon, causing infection....
Irritable Bowel Syndrome (IBS) Quiz
What are symptoms of irritable bowel syndrome (IBS)? Take this quiz and get quick facts on causes and treatment options for this...
Irritable Bowel Syndrome: The IBS Survival Kit
If you have IBS, you know that symptoms can show up at any time. WebMD's slideshow describes some things you can carry with you...
Related Disease Conditions
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome or IBS is a GI disorder with symptoms of constipation, abdominal pain, bloating, and gas. IBS treatment includes medications, dietary changes, and lifestyle changes.
Most people with diverticulosis have few if any symptoms at all. When people do experience signs and symptoms of diverticulosis (diverticular disease) they may include abdominal pain, abdominal cramps, diarrhea, constipation, and bloating. Diverticulitis is a condition in which diverticula in the colon rupture. The rupture results in infection in the tissues that surround the colon. Treatment methods for diverticulitis include prescription medications, and in some cases, diverticulitis surgery.
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas (flatulence), loose stools, frequent stools, abdominal pain, diarrhea, and nausea. New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
IBS Triggers (Prevention)
Irritable bowel syndrome (IBS) is a functional disease that can affect the quality of those who suffer from this condition. People with IBS can make lifestyle changes that may modify or control the number and severity of episodes. Certain foods, medications, and hormone levels may trigger IBS episodes, for example fatty foods, dairy products, eating foods in large quantities, foods that contain high levels of sorbitol, foods that produce intestinal gas (broccoli, onions, cabbage, and beans), chocolate, caffeine, physiological stress, some antibiotics, some antidepressants, medicine with sorbitol, and menstrual pain. Exercise, diet, and other lifestyle changes can decrease IBS flares, and prevent the number and severity of IBS episodes of diarrhea and constipation.
Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)
Microscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps.
How Can I Treat IBS Naturally?
Irritable bowel syndrome or IBS refers to a medical condition that affects the bowel. IBS is associated with a group of symptoms that include repeated episodes of pain or cramps in the abdomen, bloating, and changes in bowel movements, which may be diarrhea, constipation, or both. Read about 6 lifestyle changes.
What Helps IBS During Pregnancy?
Learn thirteen ways to successfully deal with irritable bowel syndrome (IBS) during pregnancy to ease symptoms and keep your baby healthy.
What Are the First Signs of Irritable Bowel Syndrome?
Irritable bowel syndrome (IBS) is a common intestinal disorder that is characterized by abdominal pain and changes in bowel habits. IBS is a chronic condition that may cause either diarrhea or constipation, depending on the person.
What Are the Symptoms of IBS in Women?
While many symptoms of irritable bowel syndrome (IBS) are common in both men and women, some are exclusive to women.
Symptoms Of An IBS Attack- What To Know
IBS or irritable bowel syndrome is a medical condition affecting the large bowel. It is a type of functional bowel or gastrointestinal (GI) disorders. This means that although it causes disturbing symptoms, it does not cause any structural damage to the bowel.
Is Irritable Bowel Syndrome Part of Fibromyalgia?
Yes, they are associated with each other. Fibromyalgia is linked with several different conditions, including IBS. IBS is also linked to other conditions that are not fibromyalgia.
Irritable Bowel Syndrome Foods To Avoid
Irritable bowel syndrome or IBS is a medical condition affecting the large bowel. It is a group of symptoms occurring together, including repeated pain in the abdomen, cramping, bloating and changes in the bowel movements, which may be diarrhea, constipation or both.
Where Do You Feel Irritable Bowel?
Irritable bowel syndrome (IBS) affects bowel function with symptoms that include abdominal pain or discomfort, which may feel like abdominal cramping.
Treatment & Diagnosis
- Irritable Bowel Syndrome IBS FAQs
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Rifaximin (Xifaxan) for Irritable Bowel Syndrome (IBS) Treatment
- Irritable Bowel Syndrome & Abdominal Pain - Common in Teens
- Alosetron-New Drug for Irritable Bowel
- Are antidepressants useful for IBS?
- IBS: Doing The Right Thing
- Irritable Bowel Drug Lotronex Yanked By FDA - Warning
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Tegaserod (Zelnorm)...New Drug for Irritable Bowel Syndrome
- Does IBS Cause Crohn's Disease or Ulcerative Colitis?
- Generic Drugs, Are They as Good as Brand-Names?
- Irritable Bowel Syndrome (IBS): What Do I Eat?
Medications & Supplements
- dicyclomine - oral, Bentyl
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Anticholinergic and Antispasmodic Drugs
- Side Effects of Bentyl (dicyclomine)
- chlordiazepoxide hydrochloride and clidinium bromide (Librax)
- hyoscyamine, atropine, scopolamine and phenobarbital (Donnatal)
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Some sections provided courtesy of the U.S. Food and Drug Administration (FDA) prescribing information