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What is dicyclomine? What are the uses for dicyclomine?
Dicyclomine is a drug that is used for treating irritable bowel syndrome (IBS). Dicyclomine is in a class of drugs called anticholinergics. Anticholinergic drugs block the effects of acetylcholine, the chemical transmitter that nerves release in order to cause muscles to contract. They prevent contraction of muscles by blocking the acetylcholine receptors on the muscle cells. Anticholinergic drugs also have a direct relaxing effect on muscle. Dicyclomine is used to reduce contraction of the muscles in the intestines. Dicyclomine was approved by the FDA in 1950.
What brand names are available for dicyclomine?
Is dicyclomine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for dicyclomine?
What are the side effects of dicyclomine?
Common side effects include:
- dry mouth (xerostomia),
- blurred vision,
- increased heart rate,
- heart palpitations,
- difficulty urinating, and
Other important side effects include:
What is the dosage for dicyclomine?
The recommended starting oral dose of dicyclomine is 20 mg given 4 times daily. The dose can be increased to 40 mg 4 times daily. The recommended intramuscular injection is 10 to 20 mg 4 times daily. The intramuscular injection is only used for 1 to 2 days if a patient cannot take capsules or tablets.
What drugs and supplements interact with dicyclomine?
Anticholinergics antagonize the effects of antiglaucoma agents and may increase intraoccular pressure. Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. Use of Bentyl in patients with glaucoma is not recommended.
Other Drugs with Anticholinergic Activity
The following agents may increase certain actions or side effects of anticholinergic drugs including Bentyl:
- antiarrhythmic agents of Class I (for example, quinidine),
- antipsychotic agents (for example, phenothiazines),
- MAO inhibitors,
- narcotic analgesics (for example, meperidine),
- nitrates and nitrites,
- sympathomimetic agents,
- tricyclic antidepressants, and
- other drugs having anticholinergic activity.
Other Gastrointestinal Motility Drugs
Interaction with other gastrointestinal motility drugs may antagonize the effects of drugs that alter gastrointestinal motility, such as metoclopramide.
Effect of Antacids
Because antacids may interfere with the absorption of anticholinergic agents including Bentyl, simultaneous use of these drugs should be avoided.
Effect on Absorption of Other Drugs
Anticholinergic agents may affect gastrointestinal absorption of various drugs by affecting on gastrointestinal motility, such as slowly dissolving dosage forms of digoxin; increased serum digoxin concentration may result.
Effect on Gastric Acid Secretion
The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those used to test gastric secretion.
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Is dicyclomine safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of the effect of dicyclomine in pregnant women at recommended doses (80-160 mg/day). Observation of women who received dicyclomine (up to 40 mg/day) containing products during the first trimester of pregnancy did not reveal any increased risk of harm to the fetus.
What else should I know about dicyclomine?
What preparations of dicyclomine are available?
Capsules: 10 mg. Tablets: 20 mg. Syrup: 10 mg/5 mL. Injection (Intramuscular): 10 mg/ mL
How should I keep dicyclomine stored?
Capsules, tablets, and injection should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Injection should be protected from freezing.
Dicyclomine (Bentyl) is a drug prescribed for the treatment of irritable bowel syndrome (IBS). Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
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Related Disease Conditions
Diverticulitis (Diverticulosis, Diverticular Disease)
Most people with diverticulosis have few if any symptoms at all. When people do experience signs and symptoms of diverticulosis (diverticular disease) they may include abdominal pain, abdominal cramps, diarrhea, constipation, and bloating. Diverticulitis is a condition in which diverticuli in the colon rupture. The rupture results in infection in the tissues that surround the colon. Treatment methods for diverticulitis includes prescription medications, and in some cases, diverticulitis surgery.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating, increased gas (flatulence), abdominal cramping, diarrhea, constipation, and food intolerance.Two new tests are now available that may help diagnose irritable bowel syndrome with diarrhea and constipation (IBS-M) irritable bowel syndrome with diarrhea (IBS-D), and irritable bowel syndrome with constipation (IBS-C). Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)
Microscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps. Microscopic colitis is diagnosed through biopsies of several areas of the colon. There is no standardized treatment for microscopic colitis; however, eliminating NSAIDs, and treatment medications such as Imodium, Lomotil, Petpo-Bismol, Entocort EC, and mesalamine (Asacol) have been helpful in some individuals.
Irritable Bowel Syndrome in Children (IBS)
Irritable bowel syndrome (IBS) in children is a functional gastrointestinal disorder with signs and symptoms of: Abdominal pain Bloating Diarrhea Constipation The cause of IBS is unknown, however, certain foods, stress, anxiety, and depression may contribute to the symptoms of IBS. There is no cure for IBS in children; however, medications, dietary changes, and stress management may relieve symptoms.
IBS Triggers (Prevention)
Irritable bowel syndrome (IBS) is a functional disease that can affect the quality of those who suffer from this condition. People with IBS can make lifestyle changes that may modify or control the number and severity of episodes. Certain foods, medications, and hormone levels may trigger IBS episodes, for example fatty foods, dairy products, eating foods in large quantities, foods that contain high levels of sorbitol, foods that produce intestinal gas (broccoli, onions, cabbage, and beans), chocolate, caffeine, physiological stress, some antibiotics, some antidepressants, medicine with sorbitol, and menstrual pain. Exercise, diet, and other lifestyle changes can decrease IBS flares, and prevent the number and severity of IBS episodes of diarrhea and constipation.
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas (flatulence), loose stools, frequent stools, abdominal pain, diarrhea, and nausea. New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
Treatment & Diagnosis
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Medications & Supplements
- hyoscyamine, atropine, scopolamine and phenobarbital (Donnatal)
- chlordiazepoxide hydrochloride and clidinium bromide (Librax)
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Anticholinergic and Antispasmodic Drugs
- Dicyclomine vs. Donnatal
- dicyclomine (Bentyl) vs. hyoscyamine (Levbid)
- Bentyl (dicyclomine) vs. Librax (chlordiazepoxide HCL and clidinium bromide)
- Bentyl (dicyclomine) vs. Linzess (linaclotide)
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Some sections provided courtesy of the U.S. Food and Drug Administration (FDA) prescribing information