dicyclomine, Bentyl

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Irritable Bowel Syndrome (IBS) Facts

What is dicyclomine, and how does it work (mechanism of action)?

Dicyclomine is a drug that is used for treating irritable bowel syndrome (IBS). Dicyclomine is in a class of drugs called anticholinergics. Anticholinergic drugs block the effects of acetylcholine, the chemical transmitter that nerves release in order to cause muscles to contract. They prevent contraction of muscles by blocking the acetylcholine receptors on the muscle cells. Anticholinergic drugs also have a direct relaxing effect on muscle. Dicyclomine is used to reduce contraction of the muscles in the intestines. Dicyclomine was approved by the FDA in 1950.

What brand names are available for dicyclomine?

Bentyl

Is dicyclomine available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for dicyclomine?

Yes

What are the side effects of dicyclomine?

Common side effects include:

Other important side effects include:

Quick GuideIBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment

IBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment

What is the dosage for dicyclomine?

The recommended starting oral dose of dicyclomine is 20 mg given 4 times daily. The dose can be increased to 40 mg 4 times daily. The recommended intramuscular injection is 10 to 20 mg 4 times daily. The intramuscular injection is only used for 1 to 2 days if a patient cannot take capsules or tablets.

Is dicyclomine safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of the effect of dicyclomine in pregnant women at recommended doses (80-160 mg/day). Observation of women who received dicyclomine (up to 40 mg/day) containing products during the first trimester of pregnancy did not reveal any increased risk of harm to the fetus.

Dicyclomine is excreted into breast milk. Since there have been reports of apnea (cessation of breathing) when dicyclomine has been given to children, it should not be used by nursing mothers.

What else should I know about dicyclomine?

What preparations of dicyclomine are available?

Capsules: 10 mg. Tablets: 20 mg. Syrup: 10 mg/5 mL. Injection (Intramuscular): 10 mg/ mL

How should I keep dicyclomine stored?

Capsules, tablets, and injection should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). Injection should be protected from freezing.

Reference: FDA Prescribing Information

Quick GuideIBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment

IBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment

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See more info: dicyclomine on RxList
Reviewed on 6/11/2015
References
Reference: FDA Prescribing Information

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