- Stages of Pregnancy Slideshow Pictures
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What is Diclegis, and how does it work?
- Diclegis is a prescription medicine used to treat nausea and vomiting of pregnancy in women who have not improved with change in diet or other non-medicine treatments.
- It is not known if Diclegis is safe and effective in women with severe nausea and vomiting of pregnancy, a condition called hyperemesis gravidarum. Women with this condition may need to be hospitalized.
- It is not known if Diclegis is safe and effective in children under 18 years of age.
What are the side effects of Diclegis?
Diclegis may cause serious side effects, including drowsiness.
Drowsiness is a common side effect when taking Diclegis, but can also be severe:
- Do not drive, operate heavy machinery, or other activities that need your full attention unless your healthcare provider says that you may do so.
- Do not drink alcohol, or take other central nervous system depressants such as cough and cold medicines, certain pain medicines, and medicines that help you sleep while you take Diclegis. Severe drowsiness can happen or become worse causing falls or accidents.
Diclegis may cause false positive urine drug screening test for methadone, opiates and PCP.
These are not all the possible side effects of Diclegis.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA1088.
What is the dosage for Diclegis?
- Initially, take two Diclegis delayed-release tablets orally at bedtime (Day 1).
- If this dose adequately controls symptoms the next day, continue taking two tablets daily at bedtime.
- However, if symptoms persist into the afternoon of Day 2, take the usual dose of two tablets at bedtime that night then take three tablets starting on Day 3(one tablet in the morning and two tablets at bedtime).
- If these three tablets adequately control symptoms on Day 4, continue taking three tablets daily. Otherwise take four tablets starting on Day 4 (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime).
- The maximum recommended dose is four tablets (one in the morning, one in the mid-afternoon and two at bedtime) daily.
- Take on an empty stomach with a glass of water. Swallow tablets whole. Do not crush, chew, or split Diclegis tablets.
- Take as a daily prescription and not on an as needed basis. Reassess the woman for continued need for Diclegis as her pregnancy progresses.
What drugs interact with Diclegis?
- Use of Diclegis is contraindicated in women who are taking monoamine oxidase inhibitors (MAOIs), which prolong and intensify the anticholinergic (drying) effects of antihistamines.
- Concurrent use of alcohol and other CNS depressants (such as hypnotic sedatives and tranquilizers) with Diclegis is not recommended.
- A food-effect study demonstrated that the delay in the onset of action of Diclegis may be further delayed, and a reduction in absorption may occur when tablets are taken with food.
- Therefore, Diclegis should be taken on an empty stomach with a glass of water.
False Positive Urine Tests For Methadone, Opiates And PCP
- False positive drug screens for methadone, opiates, and PCP can occur with doxylamine succinate/pyridoxine hydrochloride use.
- Confirmatory tests, such as Gas Chromatography Mass Spectrometry (GC-MS), should be used to confirm the identity of the substance in the event of a positive immunoassay result.
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Is Diclegis safe to use while pregnant or breastfeeding?
- Diclegis is intended for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.
- Maternal risks are discussed throughout the labeling. No increased risk for congenital malformations has been reported in epidemiologic studies in pregnant women.
- Women should not breastfeed while using Diclegis.
- The molecular weight of doxylamine succinate is low enough that passage into breast milk can be expected.
- Excitement, irritability and sedation have been reported in nursing infants presumably exposed to doxylamine succinate through breast milk. Infants with apnea or other respiratory syndromes may be particularly vulnerable to the sedative effects of Diclegis resulting in worsening of their apnea or respiratory conditions.
- Pyridoxine hydrochloride is excreted into breast milk.
- There have been no reports of adverse events in infants presumably exposed to pyridoxine hydrochloride through breast milk.
Diclegis is a prescription medicine used to treat nausea and vomiting of pregnancy in women who have not improved with change in diet or other non-medicine treatments. It is not known if Diclegis is safe and effective in women with severe nausea and vomiting of pregnancy, a condition called hyperemesis gravidarum. Women with this condition may need to be hospitalized.
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Related Disease Conditions
Pregnancy and Gestational Diabetes
Gestational diabetes is a form of diabetes that can occur during pregnancy. Pregnant women with gestational diabetes have not had the condition prior to becoming pregnant. Usually, gestational diabetes has no symptoms or signs and of gestational diabetes. Gestational diabetes can cause insulin resistance, hypoglycemia, hypoglycemia, and diabetic ketoacidosis. Treatment of gestational diabetes is managing the condition by checking your blood sugar as recommended, diet changes, getting enough exercise, and monitoring your baby's growth.
Care Before and During Pregnancy--Prenatal Care
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Ectopic Pregnancy (Tubal Pregnancy)
An ectopic pregnancy is a pregnancy located outside the inner lining of the uterus. The majority of ectopic pregnancies occur in the Fallopian tube. Signs and symptoms of an ectopic pregnancy may include abdominal pain, lack of menstrual period (amenorrhea), vaginal bleeding, fainting, dizziness, and low blood pressure. Treatment options for an ectopic pregnancy include observation, medication, or surgery.
Pregnancy Planning (Tips)
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes taking prenatal vitamins, eating healthy for you and your baby, disease prevention (for both parents and baby) to prevent birth defects and infections, avoiding certain medications that may be harmful to your baby, how much weight gain is healthy exercise safety and pregnancy, travel during pregnancy.
Preeclampsia (Pregnancy Induced Hypertension)
Preeclampsia is related to increased blood pressure and protein in the mother's urine. Preeclampsia typically begins after the 20th week of pregnancy. When preeclampsia causes seizures, it is termed "eclampsia" and is the second leading cause of maternal death of in the US. Preeclampsia is the leading cause of fetal complications. Risk factors for preeclampsia include high blood pressure, obesity, multiple births, and women with preexisting medical conditions such as diabetes, kidney disease, rheumatoid arthritis, lupus, or scleroderma. Pregnancy planning and lifestyle changes may reduce the risk of preeclampsia during pregnancy.
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some medications that have been found to cause no problems in pregnancy, however, medications such as Accutane for acne, should never be taken during pregnancy.
Hypothyroidism During Pregnancy
Hypothyroidism during pregnancy can be treated with synthetic thyroid hormones to maintain the proper thyroid hormone balance. Hypothyroidism symptoms include fatigue, weight gain, lethargy, and constipation. Treatment of hypothyroidism in pregnant women is important, because inadequate levels of thyroid hormones may affect the fetus, and child during growth and development.
Heartburn during Pregnancy
Heartburn during pregnancy is quite common. During pregnancy the lower esophageal sphincter muscle becomes weakened , which likely occurs due to the effect of the high levels of the hormones estrogen and progesterone during pregnancy. Fortunately, this resolves after pregnancy. Management of heartburn during pregnancy are generally involves lifestyle changes and avoiding foods that promote heartburn, for example, don't smoke, avoid tight clothing, eat small, frequent meals, chew gum, or sip liquids. The effect of heartburn medications on the fetus is unknown, so it is best to check with your OB/GYN if you feel you need medication to treat heartburn.
Pregnancy (Week by Week, Trimesters)
Signs and symptoms of pregnancy vary by stage (trimester). The earliest pregnancy symptom is typically a missed period, but others include breast swelling and tenderness, nausea and sometimes vomiting, fatigue, and bloating. Second trimester symptoms include backache, weight gain, itching, and possible stretch marks. Third trimester symptoms are additional weight gain, heartburn, hemorrhoids, swelling of the ankles, fingers, and face, breast tenderness, and trouble sleeping. Eating a healthy diet, getting a moderate amount of exercise, also are recommended for a healthy pregnancy. Information about the week by week growth of your baby in the womb are provided.
Breast Cancer During Pregnancy
Breast cancer occurs in about 1 in every 1,000 pregnant women. Treatment of breast cancer during pregnancy involves surgery, but it is very difficult to protect the baby from the dangerous effects of radiation and chemotherapy. It can be an agonizing to decide whether or not to undergo breast cancer treatment while one is pregnant.
Gestational Diabetes (Diabetes during Pregnancy))
Learning how to avoid gestational diabetes is possible and maintaining a healthy weight and diet before and during pregnancy can help. Discover risk factors, tests and treatments for, and signs and symptoms of gestational diabetes.
Preeclampsia and Eclampsia
Preeclampsia is a condition in pregnant women marked by high blood pressure and a high level of protein in the urine. Eclampsia occurs when preeclampsia goes untreated. Eclampsia can cause coma and death of the mother and baby. Preeclampsia symptoms include rapid weight gain, abdominal pain, headaches, blood in the urine, dizziness, and excessive vomiting and nausea. The only real cure for preeclampsia and eclampsia is the birth of the baby.
Pregnancy Diet (Menu Plans)
When a woman is pregnant she needs more vitamins, minerals, and other foods in her diet to stay healthy and deliver a healthy baby. A healthy pregnancy diet menu plan should consist of lots of fruits, vegetables, lean meats (unless you are vegan or vegetarian), and dairy. Examples of healthy pregnancy diet meal plans include: Holistic pregnancy diet Vegan or vegetarian diet Low-carb diets Begin your healthy eating plan around three months before you begin trying to conceive, and follow the same eating plan until after you have stopped breastfeeding. If you are overweight or obese, being pregnant is not the right time to try to lose weight. Discuss your options with your health-care professional.
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
Pain Relief Options for Childbirth
Women experience and tolerate pain differently. For some pregnant women, focused breathing is all they need to get through labor and childbirth; but for others, numbing of the pain is desired. There are a number of different medications a woman can take during labor and childbirth. It is important for you to learn what pain relief options are available. Please discuss the options with your health care provider well before your "birth day" so that when you are in labor you understand the choices.
Early Pregnancy Symptoms and Signs
Pregnancy symptoms can vary from woman to woman, and not all women experience the same symptoms. When women do experience pregnancy symptoms they may include symptoms include missed menstrual period, mood changes, headaches, lower back pain, fatigue, nausea, breast tenderness, and heartburn. Signs and symptoms in late pregnancy include leg swelling and shortness of breath. Options for relief of pregnancy symptoms include exercise, diet, and other lifestyle changes.
Pregnancy Changes and Body Discomforts
Pregnancy can bring challenges like weight gain, stretch marks, varicose veins, heartburn, constipation, hemorrhoids, problems sleeping, and wondering if it is safe to have sex while pregnant. Learn how to manage and move through these challenges during pregnancy.
Placenta previa is a condition during pregnancy when the placenta lies low in the uterus either partly or completely blocking the uterus. Women with placenta previa generally deliver their baby via cesarean delivery. There are several types of placenta previa: 1) a low-lying placenta, 2) a partial placenta previa, and 3) a total placenta previa, which covers and blocks the cervical opening. Women who are at risk of placenta previa are women who have delivered a previous baby by cesarean section, and are also at risk of placenta accreta, placenta increta, or placenta percreta.
Pregnancy: Swine Flu and the H1N1 Vaccine
Pregnant and women who are breastfeeding are encouraged to receive the seasonal flu shot as well as the 2009 H1N1 influenza (swine flu) vaccine. H1N1 flu is treated with the medications Tamiflu® (oseltamivir) or Relenza® (zanamivir). Pregnant women should not receive the H1N1 attenuated nasal spray vaccine. Possible side effects of the H1N1 flu vaccine include muscle aches, fever, nausea, tiredness, or headache.
Shingles and Pregnancy
Becoming infected with chickenpox during pregnancy could cause birth defects in your unborn child. Likewise, shingles could also cause problems for your unborn child. If you are pregnant and haven't had chickenpox, avoid exposure to infected people. Zostavax, the shingles vaccine, can reduce the incidence of shingles by half. Women should wait at least three months after receiving the vaccine before trying to get pregnant.
Smoking During Pregnancy
Smoking during pregnancy increases the risk of miscarriage or stillbirth, low birth weight or premature birth, and more. Secondhand smoke also increases your baby's risk of developing: lung cancer, heart diseases, emphysema, asthma, allergies, and SIDS.
Bleeding During Pregnancy (First Trimester)
Bleeding during pregnancy is never normal. Causes of bleeding during the first trimester of a pregnancy may be caused by implantation bleeding, ectopic or tubal pregnancy, subchorionic hemorrhaging, infections, and miscarriage. Bleeding during the second and third trimesters of pregnancy can be caused by a variety of factors.
PMS vs. Pregnancy (Differences and Similarities)
Many women have difficulty figuring out if they are pregnant, have PMS, or are about to start their period. The most common signs and symptoms of early pregnancy, PMS, and the start of your period include mood swings, back pain, increased urination, and tender breasts. These three conditions also share other similar signs and symptoms, but there are unique differences between each. Moreover, there are symptoms that only occur if you are pregnant. Early pregnancy symptoms, PMS, and the start of the menstrual period all have common signs and symptoms like mood swings, back pain, and breast pain. Symptoms and signs between the three conditions that may seem similar, but are slightly different include the following: Pelvic or abdominal cramping before or during your menstrual period is normal; however, the cramping of early pregnancy is mild. If you are pregnant, nausea and vomiting, or morning sickness, is common. They are not common symptoms of PMS. Fatigue is common in both, but PMS usually goes away once your period begins. Food cravings or aversions to certain foods are common in both pregnancy and PMS, but if you are pregnant, the cravings or aversions to foods are more specific and intense. You may have spotting or bleeding if you are pregnant or suffering from PMS. When the embryo inserts itself into the uterus (implantation bleeding), you may mistake it as your menstrual period. However, implantation bleeding is much lighter (not enough to soak a pad or tampon) than the heaving bleeding experienced at the beginning of your period. Signs and symptoms that you may have only if you are pregnant include, implantation cramping and bleeding, a white, milky vaginal discharge, and your areolas or nipples darken. The only way to find out if you are pregnant is with a pregnancy test. Home pregnancy test kits are available without a prescription at pharmacies and most grocery stores. Contact a doctor or other health care professional if you think you may be pregnant.
Multiple Sclerosis (MS) and Pregnancy
Multiple sclerosis or MS is a central nervous system disease in which the immune system attacks the myelin sheath (the protective coating around nerves). Symptoms of MS include pain, sexual problems, fatigue, numbness and tingling, emotional changes, and depression.Women who are pregnant and have multiple sclerosis may have more difficulty carrying a pregnancy. Multiple sclerosis does not affect ability to conceive, and does not seem to affect fertility. MS symptoms during pregnancy may stay the same or get better; however, they may worsen after giving birth. Pregnancy decreases the number of relapses, but flares increase in the first 3-6 months after delivery. Pregnant women with MS may carrying a pregnancy more difficult to tell when labor starts, and there is an increased need to use forceps or vacuum to assist with delivery or b7 C-section (Cesarean birth) increases. Some treatment MS drugs may be safe to use during pregnancy; however, some drugs should not be taken, for example, baclofen (Gablofen, Lioresal), fluoxetine (Prozac, Sarafem), or solifenacin succinate (VESIcare), and most disease-modifying therapies (DMTs). Talk with your healthcare team about vitamins, supplements, and medications that you are taking if you are pregnant and have MS.
DVT (Deep Vein Thrombosis) During Pregnancy
Deep vein thrombosis or DVT is a condition in which a blood clot becomes embedded in one of the deep veins of the arms, thighs, pelvis, or lower legs. Warning signs and symptoms of DVT include pain, warmth, redness, swelling, leg cramps, and worsening leg pain in the affected extremity. Many conditions and other factors can cause DVTs, for example, during pregnancy including postpartum (6-8 weeks after delivery of the baby), obesity, heart attacks or heart failure, cancer, birth control pills (oral contraceptives), recent surgery, high altitudes, and advanced age. Treatment guidelines for DVT diagnosed during pregnancy is anticoagulation (anti-clotting) drugs, usually, low-molecular-weight heparins. DVT treatment may need to be continued postpartum. Warfarin (Coumadin, Jantoven) should not be used to treat DVT during pregnancy because it can harm the developing fetus.
Pregnancy Discomforts: Common Causes
During pregnancy, most women will experience discomforts during the 1st, 2nd, and 3rd trimesters. Common causes of discomforts during pregnancy include nausea and vomiting (morning sickness), fatigue, breast swelling and pain, hemorrhoids, stretch marks, mood swings, dizziness, migraines, tooth pain and bleeding gums, and pica. Common causes of pregnancy discomforts include constipation, heartburn, indigestion, reflux, varicose veins, abdominal pain, problems sleeping, congested or bloody nose, and flu like body aches.
Safest Rheumatoid Arthritis Drugs During Pregnancy
None of the drugs used in the treatment of rheumatoid arthritis (RA) is completely safe during pregnancy. You must discuss with your physician regarding the decision to use, modify, or stop any medications.
Is Rituximab Safe During Pregnancy?
Rituxan (Rituximab) may not be completely safe during pregnancy and should be stopped at least 12 months before attempting to conceive.
Can Rheumatoid Arthritis Affect Pregnancy?
Yes, rheumatoid arthritis (RA) affects pregnancy. RA can lead to complications like preterm birth, raised blood pressure (preeclampsia), and low birth weight babies.
Early Signs and Symptoms of Pregnancy
The signs and symptoms of pregnancy differ from woman to woman. All the signs of pregnancy may not be seen in one person. Additionally, the signs may appear in different persons at different times.
Early Pregnancy Symptoms Before Missed Period
Pregnancy symptoms vary from one woman to another. Women could have none of the symptoms but can still go on to have a perfectly healthy pregnancy. Usually missing a period after conception is considered a sign of pregnancy.
How Soon Can You Get Symptoms of Pregnancy?
Early symptoms of pregnancy are usually different for every woman. Some women might experience the first symptoms a week or two after conceiving, whereas others don’t feel anything for months. Many women may tell if they are pregnant within two or three weeks of conceiving, and some women know a lot sooner, even within a few days
How Soon Can I Take A Pregnancy Test?
You may take a pregnancy test as soon as you miss a period or if your period is late. You would know the date of your missed period if your periods are regular. It is recommended to take a pregnancy test as soon as possible if you miss your period or think you might be pregnant.
How Soon Can I Take A Pregnancy Test After a Missed Period?
You may take a pregnancy test as soon as you miss a period or if your period is late. You would know the date of your missed period if your periods are regular. If your periods are irregular, or you do not have periods for some reason, you can do a pregnancy test at least three weeks after having sexual intercourse.
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