- Understanding COPD Slideshow
- COPD (Chronic Obstructive Pulmonary Disease) Quiz
- Energy Foods for COPD Slideshow Pictures
- What is dexamethasone-injectable, and how does it work (mechanism of action)?
- What brand names are available for dexamethasone-injectable?
- Is dexamethasone-injectable available as a generic drug?
- Do I need a prescription for dexamethasone-injectable?
- What are the side effects of dexamethasone-injectable?
- What is the dosage for dexamethasone-injectable?
- Which drugs or supplements interact with dexamethasone-injectable?
- Is dexamethasone-injectable safe to take if I'm pregnant or breastfeeding?
- What else should I know about dexamethasone-injectable?
What is dexamethasone-injectable, and how does it work (mechanism of action)?
Dexamethasone is a synthetic (created by a chemical processes) corticosteroid hormone like prednisone, betamethasone, and triamcinolone. More specifically, dexamethasone is a glucocorticoid hormone, which means that it has anti-inflammatory effects, as well as the ability to affect blood glucose use, fat breakdown, and bone development depending on where it binds in the body. Dexamethasone reduces inflammation by preventing immune cells, such as neutrophils, from migrating to the site of action, reducing the release of inflammatory signals, as well as decreasing how well substances may pass in and out of the blood vessels. It also has anti-vomiting properties (antiemetic). The FDA approved dexamethasone in 1958.
What brand names are available for dexamethasone-injectable?
Baycadron, Decadron (Discontinued), Dexamethasone Intensol
What are the side effects of dexamethasone-injectable?
Glucocorticoids are associated with a variety of side effects based on dose and duration of therapy. Dexamethasone may commonly cause an increase in blood sugar, appetite, insomnia, acne, and nervousness or emotional instability (depression or euphoria). It may also cause impaired wound healing, high blood pressure, raised pressure in the eye, and cataracts. Serious side effects include risk of cardiomyopathy, induced diabetes mellitus, pancreatitis, osteoporosis (bone loss), and conjunctival hemorrhage.
Quick GuideCOPD Lung Symptoms, Diagnosis, Treatment
What is the dosage for dexamethasone-injectable?
The dose for dexamethasone is based on whether is administered intravenously or by intramuscular injection as well as the severity of the condition requiring treatment. Consult the official prescribing information for dosing regimens.
Which drugs or supplements interact with dexamethasone-injectable?
Dexamethasone may decrease levels of drugs that are broken down by liver enzymes. Examples include abiraterone, apixaban (Elquis), aripiprazole (Abilify), boceprevir (Victrelis), dronedarone (Multaq), and quetiapine (Seroquel, Seroquel XR) . Consider increasing the dose of the drug or avoiding this combination altogether. Adverse effects, such as bone marrow suppression, are enhanced when dexamethasone is used with other immunosuppressants such as leflunomide (Arava) and tacrolimus (Prograf). Dosing schedules should be evaluated and alternative therapies should be considered. Live vaccines should also be avoided because dexamethasone reduces immune function.
Is dexamethasone-injectable safe to take if I'm pregnant or breastfeeding?
Category C; animal reproduction studies show adverse events with corticosteroid use. Dexamethasone has the potential to cross the placenta to affect fetal growth. Lowest effective doses should be used for the shortest duration of time, with avoidance of dosing in the first trimester to help avoid oral clefts. Low adrenal function may also develop in newborns if corticosteroid exposure occurs while in the womb.
Corticosteroids are excreted in breast milk, and, therefore should be used cautiously by nursing mothers. If dexamethasone is absolutely needed and breastfeeding cannot be stopped, a separation of 4 hours between therapy and breastfeeding is recommended to decrease exposure of the infant to the corticosteroid.
What else should I know about dexamethasone-injectable?
What preparations of dexamethasone-injectable are available?
Injection solution: 4 mg/mL and 10 mg/ml; 1 mg/ml
How should I keep dexamethasone-injectable stored?
Dexamethasone should be stored as intact vials at room temperature, between 20 C to 25 C (68 F to 77 F). Protect from light and heat. Do not freeze. If diluted, use within 24 hours.
Dexamethasone injection (Baycadron, Decadron [Discontinued], Dexamethasone Intensol) is a synthetic corticosteroid hormone prescribed for vomiting; a wide variety of conditions such as allergies, diseases that involve the endocrine, renal, respiratory, rheumatic, autoimmune, blood, inflammatory, kidney, nervous system; and skin conditions. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
Related Disease Conditions
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. Strictly...
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding....
The word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different...
Lung Anatomy (Structure and Function)
The lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood....
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness...
A keloid is a scar that doesn't know when to stop. When the cells keep on reproducing, the result is an overgrown (hypertrophic)...
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and...
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Daily Health News
Subscribe to MedicineNet's Allergy and Asthma Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top dexamethasone-injectable Related Articles
ArthritisArthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
CancerCancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
KeloidA keloid is a scar that doesn't know when to stop. When the cells keep on reproducing, the result is an overgrown (hypertrophic) scar or a keloid. A keloid looks shiny and is often dome-shaped, ranging in color from slightly pink to red. It feels hard and thick and is always raised above the surrounding skin.
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which inflames the vocal cords. Symptoms may vary from degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup). Common symptoms include
- a "barky" cough,
- a hoarse cough,
- runny nose,
- dry cough, and
- loss of voice.
Chronic laryngitis generally lasts more than three weeks. Causes other than infection include smoking, excess coughing, GERD, and more. Treatment depends on the cause of laryngitis.
LeukemiaLeukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
Lungs Design And PurposeThe lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood. Eliminating carbon dioxide from the blood is important, because as it builds up in the blood, headaches, drowsiness, coma, and eventually death may occur. The air we breathe in (inhalation) is warmed, humidified, and cleaned by the nose and the lungs.
RashThe word "rash" means an outbreak of red bumps on the body. The way people use this term, "a rash" can refer to many different skin conditions. The most common of these are scaly patches of skin and red, itchy bumps or patches all over the place.
Ulcerative ColitisUlcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.