desoximetasone topical

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is desoximetasone-topical, and how does it work (mechanism of action)?

  • Desoximetasone is a synthetic (man-made) corticosteroid that is used on the skin (topically). The naturally-occurring corticosteroid is cortisol or hydrocortisone produced by the adrenal gland. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response.
  • The FDA approved desoximetasone in March 1982.

What brand names are available for desoximetasone-topical?


Is desoximetasone-topical available as a generic drug?


Do I need a prescription for desoximetasone-topical?


What are the uses for desoximetasone-topical?

What are the side effects of desoximetasone-topical?

Common side effects of Topicort include:

  • Burning
  • Itching
  • Irritation
  • Dryness

Other side effects include:

Other less common side effects include:

Possible serious side effects include:

  • Maceration of the skin
  • Secondary infection
  • Skin atrophy

Prolonged use (greater than two weeks) of high doses of Topicort can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping Topicort in these individuals can cause symptoms of corticosteroid insufficiency, along with:

What is the dosage for desoximetasone-topical?

  • A thin film of Topicort should be applied to the affected areas twice daily.
  • Using Topicort beyond 4 weeks is not advisable.

Which drugs or supplements interact with desoximetasone-topical?

There are no drug interactions listed for this product.

Is desoximetasone-topical safe to take if I'm pregnant or breastfeeding?

  • Topicort has not been adequately evaluated in pregnant women. Pregnant patients should not use corticosteroids extensively, in large amounts, or for prolonged periods of time.
  • It is not known if Topicort is secreted in breast milk.

What else should I know about desoximetasone-topical?

What preparations of desoximetasone-topical are available?

  • Cream: 0.05, 0.25%
  • Gel: 0.05%
  • Ointment: 0.25%
  • Spray: 0.25%

How should I keep desoximetasone-topical stored?

Store Topicort at room temperature between 15 C - 30 C (59 F - 86 F)


Topicort (Topicort LP has been discontinued) or topical desoximetasone as it's known by its generic name is a medication prescribed to treat moderate to severe plaque psoriasis. Side effects of Topicort include

  • irritation,
  • dryness,
  • burning, and
  • itching.

Drug interactions, dosage, and pregnancy and breastfeeding information should be reviewed prior to using any medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

Health Solutions From Our Sponsors

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

REFERENCE: FDA Prescribing Information