desoximetasone cream, ointment, spray, gel (Topicort)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is topical desoximetasone, and how does it work (mechanism of action)?

  • Desoximetasone is a synthetic (man-made) corticosteroid that is used on the skin (topically). The naturally occurring corticosteroid is cortisol or hydrocortisone produced by the adrenal gland. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response.
  • The FDA approved desoximetasone in March 1982.

What brand names are available for topical desoximetasone?

Topicort

Is topical desoximetasone available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for topical desoximetasone?

Yes

What are the uses for topical desoximetasone?

  • Topicort is used for treating adults (>18 yr) with moderate to severe plaque psoriasis.
  • It also is used for treating other skin conditions that are responsive to corticosteroids.

What are the side effects of topical desoximetasone?

Common side effects of Topicort include:

Other side effects include:

Other less common side effects include:

Possible serious side effects include:

  • Maceration of the skin
  • Secondary infection
  • Skin atrophy

Prolonged use (greater than two weeks) of high doses of Topicort can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping Topicort in these individuals can cause symptoms of corticosteroid insufficiency, along with:

What is the dosage for topical desoximetasone?

  • A thin film of Topicort should be applied to the affected areas twice daily.
  • Using Topicort beyond 4 weeks is not advisable.

Which drugs or supplements interact with topical desoximetasone?

There are no drug interactions listed for this product.

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Is topical desoximetasone safe to take if I'm pregnant or breastfeeding?

  • Topicort has not been adequately evaluated in pregnant women. Pregnant patients should not use corticosteroids extensively, in large amounts, or for prolonged periods of time.
  • It is not known if Topicort is secreted in breast milk.

What else should I know about topical desoximetasone?

What preparations of topical desoximetasone are available?

  • Cream: 0.05, 0.25%
  • Gel: 0.05%
  • Ointment: 0.25%
  • Spray: 0.25%

How should I keep topical desoximetasone stored?

Store Topicort at room temperature between 15 C - 30 C (59 F - 86 F).

Summary

Topicort (Topicort LP has been discontinued) -- or topical desoximetasone cream, ointment, spray, or gel as it's known by its generic name -- is a medication prescribed to treat moderate to severe plaque psoriasis. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to using any medication.

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Medically Reviewed on 8/15/2019
References
FDA Prescribing Information
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