desmopressin acetate (DDAVP, Stimate, Minirin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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What is desmopressin tabs, and how does it work (mechanism of action)?

Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration. In people with diabetes insipidus due to trauma or surgery in the pituitary region of the brain, it reduces frequent urination and thirst. The FDA approved desmopressin in February 1978.

What brand names are available for desmopressin tabs?

DDAVP, Stimate

Is desmopressin tabs available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for desmopressin tabs?

Yes

What are the side effects of desmopressin tabs?

Side effects of Desmopressin are:

Changes in blood pressure, low sodium levels, and increased heart rate may occur.

What is the dosage for desmopressin tabs?

Central diabetes insipidus:

  • Adults and children 12 years of age and older: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 1.2 mg divided every 8 to 12 hours.
  • Children of 4 years to under 12 years of age: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 0.8 mg divided every 8 to 12 hours.
  • The intranasal dose for adults and children older than 12 years old is 10 to 40 mcg per day or divided and given in 2 or 3 doses (every 8 or 12 hours). The dose for children 3 months to 12 years is 5 to 30 mcg daily or divided and given every 12 hours.
  • The intravenous dose for adults and children older than 12 years of age is 2 to 4 mcg daily. Children 3 months to 12 years old should receive 0.1-1 mcg per day or divided and given every 12 hours.

Primary nocturnal enuresis:

  • Adults and children 6 years of age and older: 0.1 to 0.2 mg orally at bedtime. (May increase up to 0.6 mg if necessary)

Which drugs or supplements interact with desmopressin tabs?

Desmopressin should be used with caution with drugs tricyclic antidepressants, selective-serotonin reuptake inhibitors, NSAIDs, lamotrigine (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), and opiate analgesics due to increased risk of water intoxication with extremely low sodium levels.

Is desmopressin tabs safe to take if I'm pregnant or breastfeeding?

There are no adequate studies done on Desmopressin to determine safe and effective use in pregnant women.

Desmopressin may be distributed in breast milk; however, there are no adequate studies done to determine infant risk. It should be used with caution by nursing mothers.

What else should I know about desmopressin tabs?

What preparations of desmopressin tabs are available?

Tablets: 0.1 mg and 0.2 mg; Nasal Spray: 0.01 mg/ml and 1.5 mg/ml; Injection: 4 mcg/ml.

How should I keep desmopressin tabs stored?

Store desmopressin tablets and spray at room temperature 20 C to 25 C (68 F 77 F). Refrigerate that injection at 2 C to 8 C (36 F to 46 F).

REFERENCE: DDAVP Prescribing Information.

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Reviewed on 9/28/2015
References
REFERENCE: DDAVP Prescribing Information.

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