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- What are desmopressin tabs? What is desmopressin used for?
- What are the side effects of desmopressin tabs?
- What is the dosage for desmopressin tabs?
- Which drugs or supplements interact with desmopressin tabs?
- Is desmopressin tabs safe to take if I'm pregnant or breastfeeding?
- What else should I know about desmopressin tabs?
What are desmopressin tabs? What is desmopressin used for?
Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration. In people with diabetes insipidus due to trauma or surgery in the pituitary region of the brain, it reduces frequent urination and thirst. The FDA approved desmopressin in February 1978.
What brand names are available for desmopressin tabs?
Is desmopressin tabs available as a generic drug?
Do I need a prescription for desmopressin tabs?
What are the side effects of desmopressin tabs?
Side effects of Desmopressin are:
Changes in blood pressure, low sodium levels, and increased heart rate may occur.
What is the dosage for desmopressin tabs?
Central diabetes insipidus:
- Adults and children 12 years of age and older: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 1.2 mg divided every 8 to 12 hours.
- Children of 4 years to under 12 years of age: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 0.8 mg divided every 8 to 12 hours.
- The intranasal dose for adults and children older than 12 years old is 10 to 40 mcg per day or divided and given in 2 or 3 doses (every 8 or 12 hours). The dose for children 3 months to 12 years is 5 to 30 mcg daily or divided and given every 12 hours.
- The intravenous dose for adults and children older than 12 years of age is 2 to 4 mcg daily. Children 3 months to 12 years old should receive 0.1-1 mcg per day or divided and given every 12 hours.
Primary nocturnal enuresis:
- Adults and children 6 years of age and older: 0.1 to 0.2 mg orally at bedtime. (May increase up to 0.6 mg if necessary)
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Which drugs or supplements interact with desmopressin tabs?
Desmopressin should be used with caution with drugs tricyclic antidepressants, selective-serotonin reuptake inhibitors, NSAIDs, lamotrigine (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), and opiate analgesics due to increased risk of water intoxication with extremely low sodium levels.
Is desmopressin tabs safe to take if I'm pregnant or breastfeeding?
There are no adequate studies done on Desmopressin to determine safe and effective use in pregnant women.
Desmopressin may be distributed in breast milk; however, there are no adequate studies done to determine infant risk. It should be used with caution by nursing mothers.
What else should I know about desmopressin tabs?
What preparations of desmopressin tabs are available?
Tablets: 0.1 mg and 0.2 mg; Nasal Spray: 0.01 mg/ml and 1.5 mg/ml; Injection: 4 mcg/ml.
How should I keep desmopressin tabs stored?
Store desmopressin tablets and spray at room temperature 20 C to 25 C (68 F 77 F). Refrigerate that injection at 2 C to 8 C (36 F to 46 F).
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Desmopressin acetate (DDAVP, Stimate, Minirin) is a medication prescribed for the management of thirst and urination following head trauma or surgery involving the pituitary gland, and the treatment of diabetes insipidus. Side effects, drug interactions, dosage, and storage information should be reviewed prior to taking this medication.
Related Disease Conditions
Diabetes insipidus is a condition in which the patient has frequent urination. Symptoms of diabetes insipidus include irritable, listless, fever, vomiting, or diarrhea due to the loss of large volumes of urine. There are three types of diabetes insipidus, central, nephrogenic, dipsogenic, and gestational. Treatment depends upon the type of diabetes insipidus.
Prolactinoma (Pituitary Tumor)
Prolactinoma is an adenoma (benign tumor) of the pituitary gland. Causes of many prolactinomas are unknown. Symptoms in women include: changes in menstruation and infertility, decreased libido, or painful intercourse due to vaginal dryness. The most common symptom in men is impotence (erectile dysfunction). Treatments for prolactinomas include medication and surgery.
Urinary Incontinence in Children
Urinary incontinence in children (enuresis) is twice as common in boys as in girls and may occur during the daytime or nighttime. Nighttime urinary incontinence is also called bedwetting and sleepwetting. The cause of nighttime incontinence in children is unknown. Daytime incontinence in children may be caused by an overactive bladder. Though many children overcome urinary incontinence naturally, it may be necessary to treat incontinence with medications, bladder training and moisture alarms, which wake the child when he or she begins to urinate.
Head Injury (Brain Injury)
In the United States, head injuries are one of the most common causes of death and disability. Head injuries due to bleeding are generally classified by the location of the blood within the skull, these include: epidural hematoma, subdural hematoma, subarachnoid bleed, intracranial bleed, sheer injury, edema, and skull fracture. Some common symptoms of a head injury include: vomiting, bleeding from the ear, speech difficulties, paralysis, difficulty swallowing, and body numbness. Treatment of a head injury depends on the type and severity of the injury.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
DDAVP Prescribing Information.