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- What is desmopressin tabs, and how does it work (mechanism of action)?
- What brand names are available for desmopressin tabs?
- Is desmopressin tabs available as a generic drug?
- Do I need a prescription for desmopressin tabs?
- What are the side effects of desmopressin tabs?
- What is the dosage for desmopressin tabs?
- Which drugs or supplements interact with desmopressin tabs?
- Is desmopressin tabs safe to take if I'm pregnant or breastfeeding?
- What else should I know about desmopressin tabs?
What is desmopressin tabs, and how does it work (mechanism of action)?
Desmopressin is a man-made analogue of vasopressin which is the body's natural anti-diuretic hormone released by the pituitary. It works by increasing water permeability in renal tubular cells, which decreases urine volume and increases urine concentration. In people with diabetes insipidus due to trauma or surgery in the pituitary region of the brain, it reduces frequent urination and thirst. The FDA approved desmopressin in February 1978.
What is the dosage for desmopressin tabs?
Central diabetes insipidus:
- Adults and children 12 years of age and older: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 1.2 mg divided every 8 to 12 hours.
- Children of 4 years to under 12 years of age: Initiate with 0.05 mg by mouth every 12 hours, may titrate up to 0.1 to 0.8 mg divided every 8 to 12 hours.
- The intranasal dose for adults and children older than 12 years old is 10 to 40 mcg per day or divided and given in 2 or 3 doses (every 8 or 12 hours). The dose for children 3 months to 12 years is 5 to 30 mcg daily or divided and given every 12 hours.
- The intravenous dose for adults and children older than 12 years of age is 2 to 4 mcg daily. Children 3 months to 12 years old should receive 0.1-1 mcg per day or divided and given every 12 hours.
Primary nocturnal enuresis:
- Adults and children 6 years of age and older: 0.1 to 0.2 mg orally at bedtime. (May increase up to 0.6 mg if necessary)
Which drugs or supplements interact with desmopressin tabs?
Desmopressin should be used with caution with drugs tricyclic antidepressants, selective-serotonin reuptake inhibitors, NSAIDs, lamotrigine (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), and opiate analgesics due to increased risk of water intoxication with extremely low sodium levels.
Is desmopressin tabs safe to take if I'm pregnant or breastfeeding?
There are no adequate studies done on Desmopressin to determine safe and effective use in pregnant women.
Desmopressin may be distributed in breast milk; however, there are no adequate studies done to determine infant risk. It should be used with caution by nursing mothers.
What else should I know about desmopressin tabs?
What preparations of desmopressin tabs are available?
Tablets: 0.1 mg and 0.2 mg; Nasal Spray: 0.01 mg/ml and 1.5 mg/ml; Injection: 4 mcg/ml.
How should I keep desmopressin tabs stored?
Store desmopressin tablets and spray at room temperature 20 C to 25 C (68 F 77 F). Refrigerate that injection at 2 C to 8 C (36 F to 46 F).
REFERENCE: DDAVP Prescribing Information.
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Diabetes InsipidusDiabetes insipidus is a condition in which the patient has frequent urination. Symptoms of diabetes insipidus include irritable, listless, fever, vomiting, or diarrhea due to the loss of large volumes of urine. There are three types of diabetes insipidus, central, nephrogenic, dipsogenic, and gestational. Treatment depends upon the type of diabetes insipidus.
Head InjuryIn the United States, head injuries are one of the most common causes of death and disability. Head injuries due to bleeding are generally classified by the location of the blood within the skull, these include:
- epidural hematoma,
- subdural hematoma,
- subarachnoid bleed,
- intracranial bleed,
- sheer injury, edema, and
- skull fracture.
- bleeding from the ear,
- speech difficulties,
- difficulty swallowing, and
- body numbness.
ProlactinomaProlactinoma is an adenoma (benign tumor) of the pituitary gland. Causes of many prolactinomas are unknown. Symptoms in women include:
- changes in menstruation and infertility,
- decreased libido, or
- painful intercourse due to vaginal dryness.