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- What is desloratadine, and how does it work (mechanism of action)?
- What brand names are available for desloratadine?
- Is desloratadine available as a generic drug?
- Do I need a prescription for desloratadine?
- What are the side effects of desloratadine?
- What is the dosage for desloratadine?
- Which drugs or supplements interact with desloratadine?
- Is desloratadine safe to take if I'm pregnant or breastfeeding?
- What else should I know about desloratadine?
What is desloratadine, and how does it work (mechanism of action)?
Desloratadine is an oral, long-acting antihistamine that is similar chemically to loratadine (Claritin). It is used to treat the symptoms caused by histamine. Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cells to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Desloratadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Desloratadine does not readily enter the brain from the blood and, therefore, causes less drowsiness (sedation). It is a member of a small family of non-sedating antihistamines which includes loratadine (Claritin), cetirizine (Zyrtec), fexofenadine (Allegra), and levocetirizine (Xyzal). Desloratadine was approved by the FDA in December 2001.
What is the dosage for desloratadine?
The recommended dose for adults and children 12 years or older is 5 mg daily.
For children 6 to 11 years of age the dose is 2.5 mg of the syrup or 2.5 mg of the RediTabs once daily.
Children 12 months to 5 years old should receive 1.25 mg of the syrup once daily and children 6 to 11 months old are treated with 1 mg of syrup once daily.
Desloratadine can be taken with or without food.
Is desloratadine safe to take if I'm pregnant or breastfeeding?
Desloratadine has not been studied in pregnant women.
Desloratadine passes into breast milk and should therefore be used with caution in women who are breastfeeding.
What else should I know about desloratadine?
What preparations of desloratadine are available?
Tablets: 5 mg. Orally Disintegrating (RediTabs): 2.5 and 5 mg. Syrup: 0.5 mg/1mL
How should I keep desloratadine stored?
Tablets and syrup should be stored at 25 C (77 F).
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Desloratadine (Clarinex, Clarinex Reditabs) is a medication used to treat allergies and hives (chronic urticaria) in adults and children 12 years of age and older. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
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