Is Depression a Side Effect of Celebrex?

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Ask the experts

I have been diagnosed with A.S. I was wondering if the medication Celebrex or the condition itself may effect my moods? I have had a series of small bouts of depression (lasting up to a week) recommendations to alleviate the problem.

Doctor's response

Depression has been reported in 0.1 - 1.9% of patients taking Celebrex.

Depression is more common in patients with Ankylosing Spondylitis, especially when it is actively causing pain and stiffness from chronic inflammation.  Depression in this setting is best managed with a two-pronged approach: (a) addressing the underlying inflammation with rest, anti-inflammation medications, and possibly 'second-line' medicines (such as Azulfidine or methotrexate and (b) managing depression by stress-reduction techniques, relaxation methods, exercises, and possibly medications.

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Reviewed on 1/11/2018