Is Depression a Side Effect of Celebrex?

Last Editorial Review: 1/11/2018

Ask the experts

I have been diagnosed with A.S. I was wondering if the medication Celebrex or the condition itself may effect my moods? I have had a series of small bouts of depression (lasting up to a week) recommendations to alleviate the problem.

Doctor's response

Depression has been reported in 0.1 - 1.9% of patients taking Celebrex.

Depression is more common in patients with Ankylosing Spondylitis, especially when it is actively causing pain and stiffness from chronic inflammation.  Depression in this setting is best managed with a two-pronged approach: (a) addressing the underlying inflammation with rest, anti-inflammation medications, and possibly 'second-line' medicines (such as Azulfidine or methotrexate and (b) managing depression by stress-reduction techniques, relaxation methods, exercises, and possibly medications.


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