darunavir, TMC-114 (Prezista)
Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.
Approved adult dosing
For those who have taken antiretroviral drugs before: one 600 mg tablet Prezista + one 100 mg capsule Norvir, two times a day
- Morning
Prezista 600 mg
+
Norvir
- Evening
Prezista 600 mg
+
Norvir
For those who have NEVER taken antiretroviral drugs: two 400 mg tablets Prezista + one 100 mg capsule Norvir, once a day
Prezista 400 mg
+
Norvir
Note: Prezista has been available as a 300 mg tablet (dose is two 300 mg tablets + one 100 mg capsule Norvir, two times a day), but this is being phased out.
Notes on taking this medication
- Must take Prezista with Norvir; it is approved only with the use of Norvir
- Must take with food
- Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider
Side effects
- Nausea; diarrhea; stomach discomfort
- Rash
- Liver inflammation and increased liver enzyme levels
- Elevations in cholesterol and triglycerides
- Elevated blood sugar
- Abnormal accumulation of body fat
- Persons who are allergic to sulfa drugs may be allergic to Prezista
Summary
Darunavir, TMC-114 (Prezista) is a protease inhibitor drug prescribed for the treatment of human immunodeficiency virus (HIV). Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
<http://www.hiv.va.gov/vahiv?page=treat-drug-Prezista>