- Type 2 Diabetes: Learn the Warning Signs
- Diabetes Friendly Dining
- Type 2 Diabetes: Test Your Medical IQ
- What is dapagliflozin, and how does it work (mechanism of action)?
- What brand names are available for dapagliflozin?
- Is dapagliflozin available as a generic drug?
- Do I need a prescription for dapagliflozin?
- What are the side effects of dapagliflozin?
- What is the dosage for dapagliflozin?
- Which drugs or supplements interact with dapagliflozin?
- Is dapagliflozin safe to take if I'm pregnant or breastfeeding?
- What else should I know about dapagliflozin?
What is dapagliflozin, and how does it work (mechanism of action)?
Dapagliflozin (Farxiga) is an oral medication used to improve glycemia (blood glucose) control in patients with type 2 diabetes. Dapagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. It is similar to canagliflozin (Invokana) and empagliflozin (Jardiance). SGLT2 is found in the kidney tubules and is responsible for reabsorbing the majority of glucose filtered out of the blood by the kidneys. By inhibiting SGLT2 dapagliflozin reduces the reabsorption of filtered glucose and consequently increases excretion of glucose in the urine. Dapagliflozin is not recommended for use in patients with moderate to severe kidney disease. Dapagliflozin was approved by the US FDA in January 2014.
What are the side effects of dapagliflozin?
The most common side effects associated with dapagliflozin were:
- vaginal yeast infections,
- yeast infections of the penis,
- nasopharyngitis (upper respiratory tract infections usually with associated sore throat, runny nose, nasal congestion, and sneezing),
- urinary tract infections (UTIs), and
- changes in urination (urinary urgency, urinating more often and in larger amounts).
Other reported side effects include:
What is the dosage for dapagliflozin?
- The recommended starting dose of dapagliflozin is 5 mg by mouth once daily in the morning.
- Dapagliflozin may be taken with or without food.
- The dose may be increased to 10 mg once daily in patients who require additional glycemic control. Kidney function must be assessed before starting treatment.
- Dapagliflozin should not be used in patient whose estimated glomerular filtration rate (eGFR) is <60 ml/min/1.73m2.
Which drugs or supplements interact with dapagliflozin?
: No significant drug interactions have been reported with dapagliflozin use.
Is dapagliflozin safe to take if I'm pregnant or breastfeeding?
It is not known if dapagliflozin is excreted in human breast milk. However, dapagliflozin is secreted in the milk of lactating rats, and exposure showed risk to the developing kidneys in the rat fetus. Currently, the manufacturer does not recommend use of this medication while nursing.
What else should I know about dapagliflozin?
What preparations of dapagliflozin are available?
Oral tablets: 5 and 10 mg
How should I keep dapagliflozin stored?
Tablets may be stored at room temperature, between 20 C to 25 C (68 F to 77 F).
Latest Diabetes News
Daily Health News
Multimedia: Slideshows, Images & Quizzes
Diabetes Quiz: Test Your Medical IQ
Take the Diabetes Quiz and learn the causes, signs, symptoms, and types of this growing epidemic. What does diabetes have to do...
How Diabetes Can Affect Your Feet
Learn more about diabetes related foot problems. For people with diabetes, too much glucose in the blood can cause serious foot...
Type 2 Diabetes Diagnosis, Treatment, Medication
Learn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Read how diet and exercise can help manage...
Pictures of Famous People With Diabetes
See pictures of celebrities that have been diagnosed with type 1 or type 2 diabetes including Mary Tyler Moore, Salma Hayek, and...
Type 1 Diabetes: What Are The Symptoms?
What is type 1 diabetes? Is there a cure for type 1 diabetes? Learn about type 1 diabetes symptoms, warning signs, causes, and...
Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
Discover the best and worst meals for diabetes-savvy dining. See how to avoid carbs and control your blood sugar with healthier...
Blood Sugar Swings: Tips for Managing Diabetes & Glucose Levels
Learn to better control your glucose levels by preventing blood sugar swings. Beware of caffeine, sugary foods, spices, exercise,...
Diabetes Management Tips and Preventing Complications
Learn 10 simple ways to better manage your diabetes. See tips for controlling blood sugar, diet and exercise and other helpful...
Diabetic Peripheral Neuropathy: Improve Diabetes Nerve Pain
Read about diabetic peripheral neuropathy and exercises to manage nerve pain. Learn how to cope with the symptoms of diabetic...
Pictures of 10 Muscle-Building Exercises for Diabetes
Watch this slideshow on Diabetes and Exercise. If you have diabetes, see how strengthening your muscles with these 10 weight...
Related Disease Conditions
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are...
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the...
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body....
Diabetes Treatment (Type 1 and Type 2 Medications and Diet)
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar....
Diabetes: Caring for Your Diabetes at Special Times
Taking care of a disease such as diabetes is a life-long process. Learn how to care for yourself or loved one with diabetes in...
Type 1 vs Type 2 Diabetes (Similarities and Differences)
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
REFERENCE: FDA Prescribing Information.