dalfampridine, Ampyra

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

The Effects of Multiple Sclerosis

What is dalfampridine, Ampyra, and how does it work (mechanism of action)?

Ampyra is an oral medication used for treating multiple sclerosis (MS). Its exact mechanism of action is unknown, but it is known to block movement of potassium between nerve cells. In animal studies Ampyra increased the conduction of nerve signals. The FDA approved Ampyra in December 1987.

What brand names are available for dalfampridine, Ampyra?

Ampyra

Is dalfampridine, Ampyra available as a generic drug?

GENERIC AVAILABLE: No.

Do I need a prescription for dalfampridine, Ampyra?

Yes.

What are the side effects of dalfampridine, Ampyra?

The most common side effect of Ampyra is urinary tract infections.

Other common side effects include:

Serious side effects of Ampyra include:

People with a history of seizures should not use Ampyra.

Signs and symptoms of anaphylaxis include difficulty breathing; itching, and swelling of the throat or tongue.

Quick GuideMultiple Sclerosis (MS) Symptoms and Treatment

Multiple Sclerosis (MS) Symptoms and Treatment

What is the dosage for dalfampridine, Ampyra?

The maximum recommended dose is 10 mg twice daily with or without food about 12 hours apart. Tablets should not be divided, crushed, chewed, or dissolved.

Which drugs or supplements interact with dalfampridine, Ampyra?

Drug interactions have not been identified for Ampyra.

Is dalfampridine, Ampyra safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of Ampyra in pregnant women.

It is not known whether Ampyra is excreted in human milk.

What else should I know about dalfampridine, Ampyra?

What preparations of dalfampridine, Ampyra are available?

Tablet (extended release): 10 mg

How should I keep dalfampridine, Ampyra stored?

Ampyra should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

Medically reviewed by John Cunha, DO

REFERENCE: FDA Prescribing Information.

Quick GuideMultiple Sclerosis (MS) Symptoms and Treatment

Multiple Sclerosis (MS) Symptoms and Treatment

Summary

dalfampridine (Ampyra) is a medication prescribed to patients with multiple sclerosis (MS) to improve walking. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.

Treatment & Diagnosis

Medications & Supplements

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Reviewed on 8/8/2017
References
Medically reviewed by John Cunha, DO

REFERENCE: FDA Prescribing Information.

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